A5055383787- Pluripotent Stem Cells Research
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- CRISPR and Genetic Engineering
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Renal and related cancers
- Erythrocyte Function and Pathophysiology
- Ovarian cancer diagnosis and treatment
- Cancer Research and Treatments
- Management of metastatic bone disease
- Biomedical Ethics and Regulation
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Breast Implant and Reconstruction
- Nanoparticle-Based Drug Delivery
University of California, Davis
2015-2024
UC Davis Comprehensive Cancer Center
2019-2022
University of California Davis Medical Center
2019-2022
University of California, Los Angeles
2011-2013
Broad Center
2011-2013
Abstract Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, immunosuppressive factors induced radiation on tumor cells remain to identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently upregulated with HER2 in radioresistant breast (BC) and RT-treated mouse syngeneic BC. Co-expression both receptors more frequently detected recurrent BC patients poor prognosis. CD47 preferentially HER2-expressing cells, blocking or reduces...
It is clear that neural differentiation from human pluripotent stem cells generates are developmentally immature. Here, we show the let-7 plays a functional role in developmental decision making of progenitors, controlling whether these make neurons or glia. Through gain- and loss-of-function studies on both tissue derived cells, our data specifically regulates this context by regulation key chromatin-associated protein, HMGA2. Furthermore, provide evidence let-7/HMGA2 circuit acts HES5,...
Abstract The clinical application of human-induced pluripotent stem cells (hiPSCs) requires not only the production Good Manufacturing Practice-grade (GMP-grade) hiPSCs but also derivation specified cell types for transplantation under GMP conditions. Previous reports have suggested that can be produced in absence animal-derived reagents (xenobiotics) to ease transition standards. However, facilitate use cell-based therapeutics, their progeny should xenobiotics conditions requiring extensive...
Purpose: To evaluate the accuracy of deep-learning-based auto-segmentation superior constrictor, middle inferior and larynx in comparison with a traditional multi-atlas-based method. Methods Materials: One hundred five computed tomography image datasets from 83 head neck cancer patients were retrospectively collected analyzed for deep-learning versus segmentation. Eighty-three images (40 diagnostic 43 planning tomography) used training convolutional neural network, atlas-based model...
Epithelial to mesenchymal transitions (EMTs) are thought be essential generate diversity of tissues during early fetal development, but these events essentially impossible study at the molecular level in vivo humans. The first EMT event that has been described morphologically human development occurs just prior generation primitive streak. Because embryonic stem cells (hESCs) and induced pluripotent (hiPSCs) most closely resemble found epiblast-stage embryos formation streak, we sought...
Skin cancer is the most commonly diagnosed malignancy in United States, and invasive cutaneous melanoma responsible for vast majority of skin cancer-related deaths. Treatment options patients with regional nodal disease, in-transit metastases, or locally advanced distant metastatic disease are challenging. Historically survival rates this patient population dismal. Improved systemic control possible using targeted agents checkpoint inhibitors have redefined treatment outcomes. Furthermore,...
Brown adipose tissue (BAT) has been mainly investigated as a potential target against cardiometabolic disease, but it also linked to cancer-related outcomes. Although preclinical data support that BAT and the thermogenic adipocytes in white may play an adverse role pathogenesis of cancer cachexia, results from studies patients have reported inconsistent results. The purpose this study was examine interrelationship between presence detectable BAT, changes body weight, cachexia with cancer. We...
Abstract Accumulating studies are aimed to combine immunoregulation with the standard of treatment such as radiotherapy in anti-cancer therapy. A potential cross resistance tumor cells will be a barrier furthering long-term control by combined treatment. CD47, an immunoglobulin-like transmembrane protein, enables cancer escape immune surveillance flagging them ‘don’t eat me’ signal, which is recognized signal regulatory protein α (SIRPα) on macrophages. Here, we report that CD47 expression...
OBJECTIVE: To develop a human in vitro model of Ataxia Telangiectais (A-T) for efficient screening novel therapeutic compounds. BACKGROUND: Telangiectasia is an early onset progressive neurodegenerative disease caused by loss function mutations ATM. ATM protein kinase that plays crucial role cellular response to double stranded-DNA break. Thus far, animal models A-T have failed show many aspects the disease, including cerebellar ataxia, most debilitating symptom patients. DESIGN/METHODS:...