A5109855385- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- RNA modifications and cancer
- Polymer Surface Interaction Studies
- Cancer-related molecular mechanisms research
- Dendrimers and Hyperbranched Polymers
- Plant biochemistry and biosynthesis
- Carbon and Quantum Dots Applications
- Ubiquitin and proteasome pathways
- Mesoporous Materials and Catalysis
- Glycosylation and Glycoproteins Research
- Plant tissue culture and regeneration
- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Wood and Agarwood Research
- Cancer-related gene regulation
- Microbial bioremediation and biosurfactants
- Peptidase Inhibition and Analysis
- Virus-based gene therapy research
- Pesticide and Herbicide Environmental Studies
- Plant Pathogens and Fungal Diseases
Hubei University of Technology
2023-2025
Henan University of Science and Technology
2024-2025
Chinese PLA General Hospital
2022-2024
Hubei University
2015-2024
Xiamen University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
Fudan University
2023-2024
East China Normal University
2017-2024
Huashan Hospital
2024
Capital Medical University
2019-2024
Hypoxia, a typical feature of solid tumors, remarkably restricts the efficiency photodynamic therapy (PDT). Here, carbon nitride (C3N4)-based multifunctional nanocomposite (PCCN) for light-driven water splitting was used to solve this problem. Carbon dots were first doped with C3N4 enhance its red region absorption because light could be trigger in vivo process. Then, polymer containing protoporphyrin photosensitizer, polyethylene glycol segment, and targeting Arg-Gly-Asp motif synthesized...
Discovering advanced materials for regulating cell death is of great importance in the development anticancer therapy. Herein, by harnessing recently discovered oxidative stress regulation ability p53 and Fenton reaction inducing capability metal–organic network (MON), MON encapsulated with plasmid (MON-p53) was designed to eradicate cancer cells via ferroptosis/apoptosis hybrid pathway. After confirming detailed mechanism MON-p53 evoking ferroptosis, we further that mediated a "bystander...
In this paper, the α−β cyclodextrin dimer is designed via "click" chemistry to connect hydrophilic and hydrophobic segments form self-assembled noncovalently connected micelles (NCCMs) through host−guest interactions. A peptide containing Arg-Gly-Asp (RGD) sequence was introduced NCCMs as a target ligand improve cell uptake efficacy, while PEGylated technology employed benzoic-imine bonds protect ligands in normal tissues body fluid. addition, two fluorescent dyes were conjugated different...
Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences structural or symptomatic features are not well understood, but may include systemic inflammation associated with increased adiposity. In this study, we examined biomechanical, neurobehavioral, inflammatory, osteoarthritic changes C57BL/6J mice fed high-fat diet.Female were either 10% kcal fat 45% diet from 9 to 54 weeks age....
We investigated whether polycystin-1 is a bone mechanosensor. conditionally deleted Pkd1 in mature osteoblasts/osteocytes by crossing Dmp1-Cre with Pkd1flox/m1Bei mice, which the m1Bei allele nonfunctional. assessed wild-type and Pkd1-deficient mice response to mechanical loading vivo ulna ex measuring of isolated osteoblasts fluid shear stress. found that conditional heterozygotes (Dmp1-Cre;Pkd1flox/+) null (Pkd1Dmp1-cKO) exhibited ~40 ~90% decrease, respectively, functional transcripts...
It is widely acknowledged that transcriptional diversity largely contributes to biological regulation in eukaryotes. Since the advent of second-generation sequencing technologies, a large number RNA studies have considerably improved our understanding transcriptome complexity. However, it still remains huge challenge for obtaining full-length transcripts because difficulties short read-based assembly. In present study we employ PacBio single-molecule long-read technology whole-transcriptome...
Novel PEG–polypeptide hybrid drug carriers, poly(ethylene glycol)-b-poly(L-cysteine)-b-poly(L-phenylalanine) (PEG-PCys-PPhe) triblock copolymers, were prepared via the ring-opening polymerization of amino acid N-carboxyanhydrides. The copolymers can self-assemble to form core–shell–corona micelles in aqueous solutions. shell has ability self-cross-link (SCL) by oxidation thiol groups PCys segments. morphology and stability SCL characterized TEM, DLS SEM. results showed could hold physical...
Fighting metastasis is a major challenge in cancer therapy, and stimulation of the immune system particular importance treatment metastatic cancers. Here, an integrated theranostic nanoplatform was developed for efficient highly tumors. Versatile functions including "And" logically controlled drug release, prolonged circulation time, tumor targeting, anti-metastasis were into doxorubicin (DOX) loaded, mesoporous silica nanoparticles (DOX@HIMSNs) systemic triple negative breast (TNBC). It...
Antibiotics are frequently detected in aquatic ecosystems, posing a potential threat to the freshwater environment. However, response mechanism of microalgae antibiotics remains inadequately understood. Here, impacts azithromycin (a broadly used antibiotic) on Chlorella pyrenoidosa were systematically studied. The results revealed that high concentrations (5–100 μg/L) inhibited algal growth, with 96-h half maximal effective concentration 41.6 μg/L. Azithromycin could weaken photosynthetic...
Abstract Chronic diabetic wounds remain a worldwide challenge for both the clinic and research. Given vicious circle of oxidative stress inflammatory response as well impaired angiogenesis wound tissues, healing process is disturbed poorly responds to current treatments. In this work, nickel‐based metal‐organic framework (MOF, Ni‐HHTP) with excellent antioxidant activity proangiogenic function developed accelerate chronic wounds. The Ni‐HHTP can mimic enzymatic catalytic activities enzymes...
Single-atom nanozymes (SAzymes) open new possibilities for the development of artificial enzymes that have catalytic activity comparable to natural peroxidase (POD). So far, most efforts focused on structural modulation Fe-N4 moiety mimic metalloprotein heme center. However, non-heme-iron POD with much higher activity, example, HppE, has not been mimicked successfully due its complexity. Herein, carbon dots (CDs)-supported SAzymes twisted, nonplanar Fe-O3N2 active sites, highly similar...