A5022332733- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Anesthesia and Neurotoxicity Research
- Microbial Metabolic Engineering and Bioproduction
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- MXene and MAX Phase Materials
- Topic Modeling
- Neuroscience and Neuropharmacology Research
- Natural Language Processing Techniques
- Enzyme Catalysis and Immobilization
- Chemical Synthesis and Analysis
- Graphene and Nanomaterials Applications
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cardiac Ischemia and Reperfusion
- Photoacoustic and Ultrasonic Imaging
- Protein purification and stability
- Gastroesophageal reflux and treatments
- Advanced Sensor and Energy Harvesting Materials
- Biopolymer Synthesis and Applications
- Protein Hydrolysis and Bioactive Peptides
- Numerical methods in inverse problems
- Surgical Sutures and Adhesives
- Cardiac Arrest and Resuscitation
- Wound Healing and Treatments
Hubei University
2023-2024
Tianjin University of Science and Technology
2024
Tianjin Institute of Industrial Biotechnology
2024
Chinese Academy of Sciences
2024
Sino Biological (China)
2024
Wuhan University
2018-2024
Renmin Hospital of Wuhan University
2018-2024
Hubei University of Technology
2024
Zhejiang Ocean University
2022
École Polytechnique Fédérale de Lausanne
2019
To effectively utilize skipjack tuna (Katsuwonus pelamis) processing by-products to prepare peptides with high angiotensin-I-converting enzyme (ACE) inhibitory (ACEi) activity, Neutrase was selected from five kinds of protease for hydrolyzing dark muscle, and its best hydrolysis conditions were optimized as dose 1.6%, pH 6.7, temperature 50°C using single factor response surface experiments. Subsequently, 14 novel ACEi prepared the protein hydrolysate identified TE, AG, MWN, MEKS, VK, MQR,...
Allosteric regulation by pathway products plays a vital role in amino acid metabolism. Homoserine dehydrogenase (HSD), the key enzyme for biosynthesis of various aspartate family acids, is subject to feedback inhibition l -threonine and -isoleucine. The desensitized mutants with potential production remain limited. Herein, semi-rational approach was proposed relieve inhibition. HSD from Corynebacterium glutamicum ( Cg HSD) first characterized as homotetramer, nine conservative sites at...
Abstract Catalytic medicine, using enzymes or nanozymes, is an emerging method for cancer treatment. However, its applicability limited by the low catalytic activity in tumor microenvironment (TME). In this work, a versatile and synthesis‐friendly nanozyme, CeO 2 Mn 1.08 O x nanoclusters, prepared. This novel Ce─Mn heterojunction formed oxidation of nanoparticles through H SO 4 /KMnO . exhibits high multi‐enzymatic activities acts as catalase (CAT), peroxidase (POD), oxidase (OXD) mimics...
Abstract l -Threonine is an important feed additive with the third largest market size among amino acids produced by microbial fermentation. The GRAS (generally regarded as safe) industrial workhorse Corynebacterium glutamicum attractive chassis for -threonine production. However, present production in C. cannot meet requirement of industrialization due to relatively low level and accumulation large amounts by-products (such -lysine, -isoleucine, glycine). Herein, enhance biosynthesis ,...
The paper describes the submission of team "We used bert!" to shared task Gendered Pronoun Resolution (Pair pronouns their correct entities). Our final model based on fine-tuned BERT (Bidirectional Encoder Representations from Transformers) ranks 14th among 838 teams with a multi-class logarithmic loss 0.208. In this work, contribution transfer learning technique pronoun resolution systems is investigated and gender bias contained in classification models evaluated.
Ropivacaine hydrochloride is a commonly used local anesthetic in clinics. However, injection or continuous infusion of ropivacaine has been associated with several disadvantages. Accordingly, it important to develop new controlled release system for administration achieve prolong effect, improve efficacy, and minimize the side effects.We developed injectable hydroxypropyl chitin thermo-sensitive hydrogel (HPCH) combined hyaluronan (HA), which was synthesize (R)-loaded system. We then...
Ensuring the resilience of Large Language Models (LLMs) against malicious exploitation is paramount, with recent focus on mitigating offensive responses. Yet, understanding cant or dark jargon remains unexplored. This paper introduces a domain-specific Cant dataset and CantCounter evaluation framework, employing Fine-Tuning, Co-Tuning, Data-Diffusion, Data-Analysis stages. Experiments reveal LLMs, including ChatGPT, are susceptible to bypassing filters, varying recognition accuracy...
Introduction Dexmedetomidine is often used as an adjunct to total intravenous anesthesia (TIVA) for procedures requiring intraoperative neurophysiologic monitoring (IONM). However, it has been reported that dexmedetomidine might mask the warning of a neurological deficit on monitoring. Methods We reviewed neurophysiological data 47 patients who underwent surgery and IONM from March 2019 2021 at Department Neurosurgery, Renmin Hospital Wuhan University. Pre- postoperative motor function...
is a major workhorse in the industrial production of branched-chain amino acids (BCAAs). The acetohydroxyacid synthase (AHAS) encoded by
Dexmedetomidine has demonstrated protective effects against lung injury in vitro. Here, we investigated whether dexmedetomidine preconditioning protected hemorrhagic shock rats.Male Sprague-Dawley rats were randomly divided into four groups (n=8): control group, 5ug.kg-1 (DEX1) and 10ug.kg-1 (DEX2) group. Saline or administered over 20min. 30min after injection, hemorrhage was initiated the shock, DEX1 DEX2 Four hours resuscitation, protein cellular content bronchoalveolar lavage fluid,...
Background and Objective: Dizziness is a common complication of gastrointestinal endoscopy under general anesthesia. primarily caused by lack energy blood volume following fasting water deprivation. Hypertonic glucose solution (HGS) an intravenous replenishment, that increases due to its hyperosmotic characteristics can be directly absorbed from circulation. This study aimed HGS prevent dizziness after endoscopy. Methods: was double-blind, randomized, controlled study. Eligible patients were...
Dexmedetomidine has demonstrated protective effects against lung injury in vitro. Here, we investigated whether dexmedetomidine preconditioning protected hemorrhagic shock rats. Male Sprague-Dawley rats were randomly divided into four groups (n = 8): control group, 5 ug.kg−1 (DEX1) and 10 (DEX2) group. Saline or administered over 20 min. 30 min after injection, hemorrhage was initiated the shock, DEX1 DEX2 Four hours resuscitation, protein cellular content bronchoalveolar lavage fluid,...
Objective To evaluate analgesic quality of ropivacaine with three different concentrations in children receiving transverses abdominis plane(TAP) block. Methods From September 2012 to March 2013, a total 120 undergoing laparoscopic high ligation inguinal hernia combined general and TAP block were included the study, randomly divided into group 1 (n=30, 0.062 5% ropivacaine) , 2 (n =30, 0.125% 3 0.25% control saline) . The study protocol was approved by Ethical Review Board...