A5102982827- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Electrochemical Analysis and Applications
- Synthesis and Characterization of Pyrroles
- Gold and Silver Nanoparticles Synthesis and Applications
- Photodynamic Therapy Research Studies
- Antimicrobial Peptides and Activities
- Metal-Organic Frameworks: Synthesis and Applications
- Catalytic C–H Functionalization Methods
- Advanced Photocatalysis Techniques
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Cyclopropane Reaction Mechanisms
- interferon and immune responses
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Polydiacetylene-based materials and applications
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- HER2/EGFR in Cancer Research
- Wound Healing and Treatments
- Pesticide Residue Analysis and Safety
Anhui Polytechnic University
2012-2025
China Agricultural University
2016-2025
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Jinan University
2024
Chongqing University of Arts and Sciences
2021-2023
Nanjing University of Chinese Medicine
2021-2022
Shanghai Institute of Materia Medica
2022
Chinese Academy of Sciences
2022
Center for Excellence in Molecular Cell Science
2022
A thin film consisting of highly ordered and vertically oriented silica mesochannels (SMCs) was prepared on the indium tin oxide (ITO) coated glass electrode surface by chronopotentiometry. The mesochannel has a uniform pore size 2-3 nm in diameter positively charged due to grafted ammonium groups. electrostatic steric effects resulted from control charge ionic buffer concentration make SMCs permselective, favoring mass transport oppositely species repelling that similarly ones. By using...
Direct chemical modification of native antibodies in a site-specific manner remains great challenge. Ligand-directed conjugation can achieve the selective antibodies, but usually requires multiple extra steps for ligand release and cargo assembly. Herein, we report novel, traceless strategy to enable facile efficient one-step synthesis antibody-drug conjugates (ADCs) by harnessing thioester-based acyl transfer reagent. The designed reagent, consisting an optimized Fc-targeting ligand,...
Tumor microenvironment (TME), characterized by high glutathione (GSH), hydrogen peroxide (H2O2) and acidic pH levels, is favorable for the growth, invasion metastasis of cancer cells. Taking advantage specific characteristics tumors, TME-responsive GCBD NPs are designed to deliver nanoscale coordination polymers (NCPs, GA-Cu) chemotherapy drugs (doxorubicin, DOX) based on bovine serum albumin (BSA) nanocarriers into cells combined chemodynamic therapy (CDT) chemotherapy. In an environment,...
The active targeting drug delivery system based on special types of endogenous cells such as macrophages has emerged a promising strategy for tumor therapy, owing to its homing property and biocompatibility. In this work, the tumor-targeting carrying doxorubicin-loaded nanoparticles (DOX@MPF127-MCP-1, DMPM) macrophage (RAW264.7) surfaces via mediation interaction with CCR2/MCP-1 axis was exploited. Initially, amphiphilic block copolymer Pluronic F127 (PF127) carboxylated MPF127 at hydroxyl...
Abstract In response to changes in microenvironment, macrophages polarize into functionally distinct phenotypes, playing a crucial role the pathogenesis of inflammatory bowel disease (IBD). Here, we investigated effects sorting nexin 10 (SNX10), protein involved endosomal trafficking and osteoclast maturation, on regulation macrophage polarization progression mouse colitis. Our results revealed that SNX10 deficiency increased population M2-type monocytes/macrophages protected against colonic...
Glycosite-specific antibody‒drug conjugatess (gsADCs), harnessing Asn297 N-glycan of IgG Fc as the conjugation site for drug payloads, usually require multi-step glycoengineering with two or more enzymes, which limits substrate diversification and complicates preparation process. Herein, we report a series novel disaccharide-based substrates, reprogram to one-step synthesis gsADCs, catalyzed by an endo-N-acetylglucosaminidase (ENGase) Endo-S2. via ENGases has steps: deglycosylation wild-type...
Recently, the combination of chemotherapy and chemodynamic therapy (CDT) has become a desirable strategy in treatment cancer. However, satisfactory therapeutic outcome is often difficult to achieve due deficiency endogenous H2O2 O2 tumor microenvironment. In this study, CaO2@DOX@Cu/ZIF-8 nanocomposite was prepared as novel nanocatalytic platform enable CDT cancer cells. The anticancer drug doxorubicin hydrochloride (DOX) loaded onto calcium peroxide (CaO2) nanoparticles (NPs) form CaO2@DOX,...
Biofilms are responsible for most bacterial infections and significantly threaten human health. Designing effective less harmful materials to inhibit remove biofilms remains a significant challenge. Complex biofilm structures make conventional antibiotic treatments ineffective, in recent years, photothermal therapy (PTT) photodynamic (PDT) have attracted attention their ability treat drug-resistant effectively. Therefore, synergistic nanoantimicrobial system (PFH/TCPP@SL@PDA) enhances the...
Chemodynamic therapy (CDT) is a highly promising tumor treatment modality that uses the Fenton reaction to convert intracellular hydrogen peroxide (H2O2) into cytotoxic hydroxyl groups (•OH). However, therapeutic effects of CDT have been restricted by weak acidic pH values, insufficient H2O2 levels, and high glutathione (GSH) concentrations in microenvironment (TME). In this study, construct PCN-224-Pt/GOD, porphyrin-based metal–organic framework nanoparticles (PCN-224) were used as carrier...
Hepatic gluconeogenesis makes a significant contribution to the pathogenesis of obesity and its related insulin resistance. Cystathionine γ-lyase (CSE; also cystathionase), principal hydrogen sulfide (H2S)-synthesizing enzyme in liver, is involved glucose lipid metabolism disorders. However, roles precise mechanisms CSE/H2S resistance remain obscure. Here we show that CSE knockout exacerbated high-fat diet-induced mouse as well Further study elucidated inhibition AMPK signaling pathways by...
Background: With the development of bacterial resistance, range effective antibiotics is increasingly becoming more limited.The use nanoscale antimicrobial peptides (AP) in therapeutic and diagnostic methods a strategy for new antibiotics.Methods: Combining both AP cadmium selenide (CdSe) into composite material may result reagent with novel properties, such as enhanced antibacterial activity, fluorescence favorable stability aqueous solution.Results: AP-loaded CdSe NPs (AP-CdSe NPs) showed...
Photothermal therapy has been widely used in the treatment of bacterial infections. However, short photothermal effective radius conventional nano-photothermal agents makes it difficult to achieve antibacterial activity. Therefore, improving composite targeting can significantly inhibit growth. We inhibited growth Staphylococcus aureus (S. aureus) by using an extremely low concentration vancomycin (Van) and applied with molybdenum disulfide (MoS2). This simple method chitosan (CS) synthesize...
Heat stress impairs spermatogenesis primarily through increased testicular oxidative stress. Astaxanthin, a potent antioxidant, has shown beneficial effects in sperm cryopreservation. However, its potential to mitigate damage induced by elevated temperatures remains uninvestigated. In this study, male mice were administered astaxanthin (10 mg/kg/d, 50 and 100 mg/kg/d) via gavage for 21 days, with heat exposure occurring during the final 14 days. Samples collected after last treatment or...
Tumors pose a significant threat to human well-being, presenting substantial risks lives. Conventional approaches cancer treatment exhibit limited efficacy in eliminating the disease, leading undesirable outcomes and an increased likelihood of disease relapse. The application chemotherapy photothermal therapy has recently shown increasing trend, owing their negative effects exceptional specificity. Chemotherapy can potentially induce rapid reduction tumors during initial treatment. However,...