A5075938026- Advanced Data Storage Technologies
- Animal Virus Infections Studies
- Healthcare and Venom Research
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Microbial infections and disease research
- Ion Channels and Receptors
- Flavonoids in Medical Research
- MicroRNA in disease regulation
- interferon and immune responses
- Nausea and vomiting management
- Ferroelectric and Negative Capacitance Devices
- Intraocular Surgery and Lenses
- RNA modifications and cancer
- Acupuncture Treatment Research Studies
- Genetic factors in colorectal cancer
- Hippo pathway signaling and YAP/TAZ
- Biochemical and Molecular Research
- Bacillus and Francisella bacterial research
- Catalytic Processes in Materials Science
- Numerical methods for differential equations
- Reproductive Physiology in Livestock
- Dermatology and Skin Diseases
- SARS-CoV-2 and COVID-19 Research
- Reproductive System and Pregnancy
Vanderbilt University Medical Center
2025
VA Tennessee Valley Healthcare System
2025
Geriatric Research Education and Clinical Center
2025
Shandong University
2024
Nanjing Agricultural University
2022-2024
Hefei University of Technology
2023-2024
Jiangsu Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Shanghai Medical College of Fudan University
2024
Fudan University Shanghai Cancer Center
2024
Overcoming CD8+ T cell exhaustion is critical in cancer immunotherapy. Recently, an intratumor stem/progenitor-like (Tprog cell) population that mediates the persistence of antitumor responses has been defined, which can further develop into a terminally differentiated (Tterm subpopulation with potent cytotoxic functions. Tprog cells are main responders to immune checkpoint blockade therapies, yet how extrinsic signals via transcription factors control generation and tumors unclear. Here, we...
The role of Hippo-YAP in human colorectal cancer (CRC) presents contradictory results. We examined the function YAP early stages CRC by quantitatively measuring expression phospho-YAPS127 (p-YAP) and five APC-related proteins 145 sporadic adenomas from Tennessee Colorectal Polyp Study, conducting APC sequencing for 114 adenomas, analyzing YAP-correlated pathways using gene data 326 obtained Gene Expression Omnibus. p-YAP was significantly correlated with (r=0.53, P<0.0001) nuclear β-catenin...
Tumor cells remodel transcriptome to construct an ecosystem with stemness features, which maintains tumor growth and highly malignant characteristics. However, the core regulatory factors involved in this process still need be further discovered.
As one of the most common mycotoxins, deoxynivalenol (DON) can contaminate a wide range crops and foods. Porcine circovirus 2 (PCV2) is kind immunosuppressive virus, which cause porcine associated disease (PCVD) in pig farms infected with PCV2. Pigs are extremely sensitive to DON, PCV2-infected often contaminated DON. Our previous studies indicated that Bacillus amyloliquefaciens B10 (B10) has potential alleviate toxicity mycotoxins. The research was aimed at investigating effects on caused...
Type B trichothecenes commonly contaminate cereal grains and include five structurally related congeners: deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), fusarenon X (FX), nivalenol (NIV). These toxins are known to have negative effects on human animal health, particularly affecting food intake. However, the pathophysiological basis for anorexic effect is not fully clarified. The purpose of this study explore potential roles brain-gut peptides...
Aflatoxin B1 (AFB1) is a naturally-occurring mycotoxin and recognized as the most toxic foodborne toxin, particularly causing damages to kidney. Glomerular podocytes are terminally differentiated epithelial cells. AFB1 induces podocyte inflammation, proteinuria renal dysfunction. Studying mechanism of AFB1-induced inflammation murine kidney dysfunction, we detected that increased ubiquitin-dependent degradation transcription factor RelA through enhanced interaction with E3 ubiquitin ligase...
Lipopolysaccharide (LPS) is one of the important pathogenic substances E. coli and Salmonella, which causes injury to reproductive system. Ovarian dysfunction due Gram-negative bacterial infections a major cause reduced performance in geese. However, specific molecular mechanisms LPS-induced impairment sex steroid hormone synthesis have not been determined. The regulatory mechanism miRNA has proposed many physiological mechanisms. Therefore, role breeding geese exposed LPS during peak laying...
Flash memory has been widely adopted as stand-alone and embedded due to its robust reliability. However, the limited endurance obstacles further applications in storage class (SCM) proceed endurance-required computing-in-memory (CIM) tasks. In this work, optimization strategies have studied tackle concern. It is shown that by adopting channel hot electrons injection (CHEI) hole (HHI) implement program/erase (PE) cycling together with a balanced window (MW) at high-Vth (HV) mode,...
Deoxynivalenol (DON) is a common type B trichothecene mycotoxin. Exposure to DON induces kidney damage in humans and animals. Porcine circovirus 2 (PCV2) the main pathogen causing porcine associated disease (PCVD) swine farms, its target organ mainly kidney. Pigs are extremely sensitive DON, farms infected with PCV2 often contamination. The widespread use of antibiotics has made some pathogenic microorganisms resistant, probiotics considered one best alternatives antibiotics....
The patient is an elderly female, 81 years old. On September 24, 2022, he was admitted to the hospital for "blurred vision in his right eye, photophobia and tears more than 1 year". complained that had undergone phacoemulsification resection intraocular lens implantation of cataract eye a Liling City 2020 due blurred both eyes 3 , reduced after surgery. Now which progressively worsening decreasing, came our treatment.
The T-2 toxin, a major secondary metabolite of Fusarium Gramineae, is considered great risk to humans and animals due its toxicity, such as inducing emesis. mechanism emesis complex signal involving an imbalance hormones neurotransmitters, well activity visceral afferent neurons. toxin has been proven induce possess the capacity elevate expressions intestinal glucagon-like peptide-17-36 (GLP-1) glucose-dependent insulinotropic polypeptide (GIP), both which are important emetic factors. In...
Deoxynivalenol (DON), the most naturally-occurring trichothecenes, may affect animal and human health by causing vomiting as a hallmark of food poisoning. Deoxynivalenol-3-glucoside (D3G) usually co-occurs with DON its glucosylated form is another emerging safety issue in recent years. However, toxicity D3G not fully understood compared to DON, especially emetic potency. The goals this research were (1) compare effects oral intraperitoneal (IP) routes relate brain-gut peptides...