A5008188729- Circadian rhythm and melatonin
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- RNA regulation and disease
- Phagocytosis and Immune Regulation
- CRISPR and Genetic Engineering
- Effects of Radiation Exposure
- Genetics, Aging, and Longevity in Model Organisms
- RNA Interference and Gene Delivery
- Telomeres, Telomerase, and Senescence
University of California, Davis
2022-2024
Abstract Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25% one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial fatty acid oxidation (FAO) enzymes (CPT1A, CPT2 and ACAD9) immune checkpoint CD47 is dominant in recurrent GBM patients poor prognosis. A glycolysis-to-FAO metabolic rewiring associated anti-phagocytosis radioresistant cells regrown radiation syngeneic mice. Inhibition FAO by CPT1 inhibitor etomoxir or...
In utero gene editing with mRNA-based therapeutics has the potential to revolutionize treatment of neurodevelopmental disorders. However, a critical bottleneck in clinical application been lack mRNA delivery vehicles that can efficiently transfect cells brain. this report, we demonstrate intracerebroventricular (ICV) injection densely PEGylated lipid nanoparticles (ADP-LNPs) containing an acid-degradable PEG–lipid safely and effectively deliver for enzymes fetal mouse brain, resulting...
Potential systemic factors contributing to aging-associated breast cancer (BC) remain elusive. Here, we reveal that the polyploid giant cells (PGCs) contain more than two sets of genomes prevailing in aging and cancerous tissues constitute 5-10% healthy female bone marrow mesenchymal stromal (fBMSCs). The PGCs can repair DNA damage stimulate neighboring for clonal expansion. However, dying advanced-senescent fBMSCs form "spikings" which are then separated into membraned mtDNA-containing...