A5101625758- Enzyme Production and Characterization
- Phytase and its Applications
- Protein Hydrolysis and Bioactive Peptides
- Immune Response and Inflammation
- CAR-T cell therapy research
- Polysaccharides and Plant Cell Walls
- Platelet Disorders and Treatments
- Reproductive System and Pregnancy
- Microbial Metabolites in Food Biotechnology
- Virus-based gene therapy research
- Parasitic Infections and Diagnostics
- Immunotherapy and Immune Responses
- Complement system in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- RNA Interference and Gene Delivery
- Biofuel production and bioconversion
- Dermatologic Treatments and Research
- S100 Proteins and Annexins
- Cell death mechanisms and regulation
- Environmental Toxicology and Ecotoxicology
- Cancer Research and Treatments
- Dermatological and Skeletal Disorders
- Telomeres, Telomerase, and Senescence
- Phytochemistry and Bioactive Compounds
First Affiliated Hospital of Jiangxi Medical College
2025
Jiangxi Provincial People's Hospital
2025
University of California, Los Angeles
2024
University of California, Davis
2024
Weatherford College
2023
University of Arizona
2021
National Health and Family Planning Commission
2021
University of Copenhagen
2019-2020
China Pharmaceutical University
2019-2020
Rigshospitalet
2019
Abstract Background While genome-wide association studies identified some promising candidates for schizophrenia, the majority of risk genes remained unknown. We were interested in testing whether integration gene expression and other functional information could facilitate identification susceptibility related biological pathways. Results conducted high throughput sequencing analyses to evaluate mRNA blood samples isolated from 3 schizophrenia patients healthy controls. also pooled 10...
Highly efficient targeted therapy is urgently needed for multiple myeloma (MM). Mesenchymal stem cells (MSCs) are an attractive candidate of cell-based, due to their inherent tumor tropism. However, there still no MSCs-based tandem diabody treating MM. Here, we designed a dual-target therapeutic system in which human umbilical cord MSCs (UCMSCs) were engineered produce and deliver Tandab (CD3/BCMA), tetravalent bispecific with two binding sites CD3 B-cell maturation antigen (BCMA). Western...
Giardiasis and cryptosporidiosis are common enteric parasitic diseases that have similar routes of transmission. In this work, we identified epitopes within the Giardia variant-specific surface protein (VSP) sequences recognized by IgG antibodies from 13 14 (93%) sera patients with stool-confirmed giardiasis. The conserved shared among VSPs both assemblages commonly infect humans, they likely to be structural, as sodium dodecyl sulfate treatment dithiothreitol reduction decrease antibody...
ABSTRACT Cryptosporidium parvum is a protozoan parasite that causes diarrheal illness in wide range of mammalian hosts, including humans. Characteristic serum immunoglobulin G (IgG) antibody responses to antigens the 27- and 17-kDa size ranges have been shown develop after infection, several enzyme-linked immunosorbent assay (ELISA) Western blot formats used measure these IgG levels human serum. Using collection serial samples from laboratory-confirmed cryptosporidiosis patients, we compared...
Globally, more than 67 million people are living with the effects of ischemic stroke. Importantly, many stroke survivors develop a chronic inflammatory response that may contribute to cognitive impairment, common and debilitating sequela is insufficiently studied currently untreatable. 2-Hydroxypropyl-β-cyclodextrin (HPβCD) an FDA-approved cyclic oligosaccharide can solubilize entrap lipophilic substances. The goal present study was determine whether repeated administration HPβCD curtails by...
Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 (sCL-12) synergizes pathway (AP) activation. However, whether this observation dependent unknown. By application of C3-inhibitor Cp40, properdin in normal human serum bound to Aspergillus fumigatus solely a C3b-dependent manner. Cp40 also prevented binding when...
Autoantibodies play a major pathogenic role in rheumatoid arthritis. T follicular helper (Tfh) cells promote germinal center B cell and Ab responses. Excessive Tfh responses lead to autoimmunity, therefore, counterregulation is crucial. regulatory (Tfr) cells, mainly differentiated from can negatively regulate cells. Dysbiosis involved arthritis's pathogenesis. We previously demonstrated that the gut microbiota, segmented filamentous bacteria (SFB), autoimmune arthritis by inducing However,...
We have previously demonstrated a 1000-fold induction of gene expression exclusive to Epstein–Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) cells using an adenoviral vector (ad5.oriP). This platform allows us explore tumor-specific therapy with BimS (ad5.oriP.BimS), potent proapoptotic Bcl-2 family member. Ad5.oriP.BimS (25 infectious units (ifu)/cell) reduced C666-1 viability in time- and dose-dependent manner 15% survival. The effect was enhanced radiation (6 Gy). Three days...
Recurrent spontaneous abortion (RSA) effects both the physical and mental health of women reproductive age. Trophoblast dysfunction may result in RSA due to shallow placental implantation. The mechanisms underlying formyl peptide receptor 2 (FPR2) on biological functions trophoblasts remain be elucidated. present study aimed explore potential FPR2, a G protein‑coupled receptor, trophoblasts. location expression levels FPR2 villi tissue patients with were detected using immunohistochemical...
Abstract Background Hemophilia B is a bleeding disorder caused by defective factor IX (FIX), currently treated regular infusions of plasma‐derived or recombinant FIX. We propose gene therapy strategy based on the implantation cells secreting FIX enclosed in alginate microcapsules as highly desirable alternative treatment. have reported sustained delivery human (hFIX) immunocompetent mice implanted with encapsulated primary mouse myoblasts engineered to secrete hFIX. As step towards treatment...
GRIM-19 is associated with apoptosis, abnormal proliferation, immune tolerance and malignant transformation, it also plays an important role in early embryonic development. Although the homologous deletion of causes lethality mice, precise embryo implantation has not been elucidated. Here we show that endometrial receptivity implantation. Day 1 to 6 pregnant mouse uteri were collected. Immunohistochemistry studies revealed presence on luminal epithelium glandular throughout period mice. The...
Collectin-12 (collectin placenta 1, CL-P1, or CL-12) is a newly identified pattern recognition molecule of the innate immune system. Recent evidences show that CL-12 plays important roles not only in protection against certain clinically pathogens but also scavenging host molecules, leukocyte recruitment, and cancer metastasis. Furthermore, has been shown to be associated with pathogenesis human diseases such as Alzheimer’s disease multiple sclerosis lesion development. Therefore, functional...
Through to survey the northeast region in China, summarized four kinds of typical rural courtyard layout forms. Using Fluent software simulate wind velocity different forms, combined with assessment criteria ratio, considering factors such as shadow area and numbers eddy current, analyze advantages disadvantages environment existing courtyard.
Potential systemic factors contributing to aging-associated breast cancer (BC) remain elusive. Here, we reveal that the polyploid giant cells (PGCs) contain more than two sets of genomes prevailing in aging and cancerous tissues constitute 5-10% healthy female bone marrow mesenchymal stromal (fBMSCs). The PGCs can repair DNA damage stimulate neighboring for clonal expansion. However, dying advanced-senescent fBMSCs form "spikings" which are then separated into membraned mtDNA-containing...