A5020503630- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Endometrial and Cervical Cancer Treatments
- Dialysis and Renal Disease Management
- Geochemistry and Geologic Mapping
- SARS-CoV-2 and COVID-19 Research
- Tree-ring climate responses
- Microtubule and mitosis dynamics
- DNA Repair Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Plant Water Relations and Carbon Dynamics
- Computational Drug Discovery Methods
- Ubiquitin and proteasome pathways
- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Ovarian cancer diagnosis and treatment
- Hepatitis C virus research
- Cancer, Hypoxia, and Metabolism
- Cervical Cancer and HPV Research
- Ferroptosis and cancer prognosis
- Geology and Paleoclimatology Research
- Arsenic contamination and mitigation
- Cancer Genomics and Diagnostics
- Iron Metabolism and Disorders
- Colorectal and Anal Carcinomas
National Tsing Hua University
2015-2025
Natural Sciences and Engineering Research Council
2025
Sylvester Comprehensive Cancer Center
2015-2025
University of Miami
2015-2025
Bristol-Myers Squibb (United States)
2024-2025
Jingdong (China)
2023-2025
Dr. John T. Macdonald Foundation
2023-2025
University of Michigan
2021-2025
Institute of Geographic Sciences and Natural Resources Research
2017-2024
Chinese Academy of Sciences
2008-2024
BackgroundThe objective of this trial was to determine the effectiveness 1.0% C31G (SAVVY) in preventing male-to-female vaginal transmission HIV infection among women at high risk.Methodology/Principal FindingsThis a Phase 3, double-blind, randomized, placebo-controlled trial. Participants made up 12 monthly follow-up visits for testing, adverse event reporting, and study product supply. The conducted between September 2004 December 2006 Lagos Ibadan, Nigeria, where we enrolled 2153...
No new agent has improved overall survival in patients with unresectable or metastatic urothelial carcinoma when added to first-line cisplatin-based chemotherapy.In this phase 3, multinational, open-label trial, we randomly assigned previously untreated either receive intravenous nivolumab (at a dose of 360 mg) plus gemcitabine-cisplatin (nivolumab combination) every 3 weeks for up six cycles, followed by 480 4 maximum 2 years, alone cycles. The primary outcomes were and progression-free...
To identify preferred neurofilament assays and clinically validate serum light (NfL) phosphorylated heavy (pNfH) as prognostic potential pharmacodynamic biomarkers relevant to amyotrophic lateral sclerosis (ALS) therapy development.In this prospective, multicenter, longitudinal observational study of patients with ALS (n = 229), primary 20), progressive muscular atrophy 11), biological specimens were collected, processed, stored according strict standard operating procedures (SOPs)....
Abstract Background Patients with inflammatory bowel disease (IBD) have intestinal inflammation and are treated immune-modulating medications. In the face of coronavirus disease-19 pandemic, we do not know whether patients IBD will be more susceptible to infection or disease. We hypothesized that viral entry molecules angiotensin I converting enzyme 2 (ACE2) transmembrane serine protease (TMPRSS2) expressed in intestine. further their expression could affected by medication usage. Methods...
Abstract Triple-negative breast cancer (TNBC) is a collection of biologically diverse cancers characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs subtypes include two basal-like (BL1, BL2), mesenchymal (M) luminal androgen receptor (LAR) subtype. Through comprehensive analysis mutation, copy number, transcriptomic, epigenetic, proteomic, phospho-proteomic patterns we describe the genomic landscape TNBC subtypes. Mesenchymal subtype tumors display high...
Background: Descriptive data on pubertal stages for a representative population of racially and ethnically diverse boys in the United States have not been published to our knowledge.Objective: To determine at what ages reach each 5 sexual maturity genital pubic hair growth.Design Setting: Cross-sectional survey from National Health Nutrition Examination Survey III (NHANES III), 1988-1994.Participants: A population-based sample 2114 aged 8 19 years representing 16 575 753 according NHANES...
Sleep concerns are common in children with autism spectrum disorders (ASD). We identified objective sleep measures that differentiated ASD and without parental concerns, related to aspects of daytime behavior. poor sleepers differed from good on actigraphic (sleep latency, efficiency, fragmentation) polysomnographic latency) measures, were reported have more inattention, hyperactivity, restricted/repetitive behaviors. Fragmentation was correlated This work provides the foundation for focused...
Intravenous iron may promote bacterial growth and impair host defense, but the risk of infection associated with supplementation is not well defined. We conducted a retrospective cohort study hemodialysis patients to compare safety bolus dosing, which provides large amount over short period time on an as-needed basis, maintenance smaller amounts regular schedule maintain repletion. Using clinical data from 117,050 US dialysis provider merged Medicare's ESRD program, we estimated effects...
Abstract PICH is a SNF2 family DNA translocase that binds to ultra-fine bridges (UFBs) in mitosis. Numerous roles for have been proposed from protein depletion experiments, but consensus has failed emerge. Here, we report deletion of avian cells causes chromosome structural abnormalities, and hypersensitivity an inhibitor Topoisomerase II (Topo II), ICRF-193. ICRF-193-treated −/− undergo sister chromatid non-disjunction anaphase, frequently abort cytokinesis. co-localizes with Topo IIα on...
4509 Background: In the CheckMate 901 trial, combination nivolumab (NIVO) + gemcitabine-cisplatin (GC) demonstrated significant improvements in overall survival (OS) and progression-free (PFS) with compelling objective response rates (ORR; 57.6% NIVO+GC vs 43.1% GC alone) deep, durable complete responses (CR; 21.7% 11.8% patients (pts) previously untreated unresectable or metastatic urothelial carcinoma (mUC). Lymph node (LN)-only disease is a favorable prognostic factor pts mUC subset of...
Abstract There is evidence that the kynurenine pathway (KP) and particularly one of its end products, quinolinic acid (QUIN) play a role in pathogenesis several major neuroinflammatory diseases, more AIDS dementia complex (ADC). We hypothesized QUIN may be involved astrocyte apoptosis because: 1) apoptotic astrocytes have been observed brains ADC patients, 2) patients elevated cerebrospinal fluid concentrations, 3) can induce death. Primary cultures human fetal were treated with three...
To determine if parents can successfully teach their children with autism spectrum disorders to become better sleepers, we piloted small group parent education workshops focused on behavioral sleep strategies. Workshops consisted of three 2-hour sessions conducted over consecutive weeks by 2 physicians. Curricula included establishing effective daytime and nighttime habits, initiating a bedtime routine, optimizing parental interactions at during night wakings. Baseline treatment...
PICH (Plk1-interacting checkpoint helicase) was recently identified as an essential component of the spindle assembly and shown to localize kinetochores, inner centromeres, thin threads connecting separating chromosomes even during anaphase. In this paper, we have used immuno-fiber fluorescence in situ hybridization chromatin-immunoprecipitation demonstrate that associates with centromeric chromatin Furthermore, by careful analysis PICH-positive anaphase through FISH well bromo-deoxyurdine...
Sister chromatid cohesion is mediated by DNA catenation and proteinaceous cohesin complexes. The recent visualization of PICH (Plk1-interacting checkpoint helicase)-coated threads in anaphase cells raises new questions as to the role its regulation time space. In present study we show that persistent induced inhibition Topoisomerase-IIalpha can contribute sister absence complexes resolution essential for abscission. Furthermore, use an vitro separation assay investigate temporal functional...
Abstract The annual cycle of extra-tropical surface air temperature is an important component the Earth’s climate system. Over past decades, a reduced amplitude this mode has been observed in some regions. Although attributed to anthropogenic forcing, it remains unclear when dampening started. Here we use residual series tree-ring width and maximum latewood density from Tibetan Plateau >4,000 m asl reconstruct changes seasonality over three centuries. new proxy evidence suggests that...
Long non-coding RNAs (lncRNAs) are a major class of RNAs, and the functional deregulations lncRNAs have been shown to be associated with development progression BC. In this work, we conduct an integrative analysis on five re-annotated lncRNA expression datasets from Gene Expression Omnibus (GEO) which included total 891 BC samples. We identified five-lncRNA signature that was significantly DFS in training cohort 327 patients. found could effectively stratify patients dataset into high-...
Coronavirus (CoV) disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has claimed many lives worldwide and is still spreading since December 2019. The 3C-like protease (3CL pro ) papain-like (PL are essential for maturation of viral polyproteins in SARS-CoV-2 life cycle thus regarded as key drug targets disease.
Abstract Background While genome-wide association studies identified some promising candidates for schizophrenia, the majority of risk genes remained unknown. We were interested in testing whether integration gene expression and other functional information could facilitate identification susceptibility related biological pathways. Results conducted high throughput sequencing analyses to evaluate mRNA blood samples isolated from 3 schizophrenia patients healthy controls. also pooled 10...