A5101995217- Treatment of Major Depression
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Mental Health Research Topics
- Electroconvulsive Therapy Studies
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Epilepsy research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Suicide and Self-Harm Studies
- Pharmacological Receptor Mechanisms and Effects
- Functional Brain Connectivity Studies
- Healthcare Decision-Making and Restraints
- Genetic Neurodegenerative Diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Parkinson's Disease Mechanisms and Treatments
- Complementary and Alternative Medicine Studies
- Natural Compound Pharmacology Studies
- Molecular Biology Techniques and Applications
- Mindfulness and Compassion Interventions
University of Alabama at Birmingham
2013-2024
Myriad Genetics
2021
Artifex University
2020
RELX Group (Netherlands)
2020
Harvard University
2012-2016
Massachusetts General Hospital
2012-2016
The University of Texas Southwestern Medical Center
2016
Janssen (Belgium)
2016
Icahn School of Medicine at Mount Sinai
2016
Yale University
2016
Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established.To assess the nasal spray plus an oral antidepressant compared with placebo in delaying relapse depressive symptoms patients TRD stable remission after induction and optimization course antidepressant.In this phase 3, multicenter, double-blind, randomized withdrawal study conducted from October 6, 2015, February 15, 2018, at outpatient...
Approximately one-third of patients with major depressive disorder (MDD) do not respond to available antidepressants.
Objective: Ketamine, an N-methyl-d-aspartate glutamate receptor antagonist, has demonstrated a rapid-onset antidepressant effect in patients with treatment-resistant depression. This study evaluated the efficacy of twice- and thrice-weekly intravenous administration ketamine sustaining initial effects Method: In multicenter, double-blind study, adults (ages 18–64 years) depression were randomized to receive either (0.5 mg/kg body weight) or placebo, administered over 40 minutes, two three...
Current prescribing practices for major depressive disorder (MDD) produce limited treatment success. Although pharmacogenomics may improve outcomes by identifying genetically inappropriate medications, studies to date were in scope. Outpatients (N = 1167) diagnosed with MDD and a patient- or clinician-reported inadequate response at least one antidepressant enrolled the Genomics Used Improve DEpression Decisions (GUIDED) trial - rater- patient-blind randomized controlled trial. Patients as...
Patients with major depression who have an insufficient response to selective serotonin reuptake inhibitors (SSRIs) may benefit from the addition of 15 mg/day l-methylfolate, only form folate that crosses blood-brain barrier. Adding 7.5 was no more effective than adding placebo, but 15.0 plus ongoing SSRI treatment produced a 32% rate, compared 15% for augmentation placebo. Side effects in two groups were comparable type and frequency.
ContextExtracts of St John's wort are widely used to treat depression. Although more than 2 dozen clinical trials have been conducted with wort, most significant flaws in design and do not enable meaningful interpretation.ObjectiveTo compare the efficacy safety a standardized extract placebo outpatients major depression.Design SettingRandomized, double-blind, placebo-controlled trial between November 1998 January 2000 11 academic medical centers United States.ParticipantsTwo hundred adult...
Human serotonin [5-hydroxytryptamine (5-HT)] transporters (hSERT, 5HTT, and SLC6A4 ) inactivate 5-HT after release are prominent targets for therapeutic intervention in mood, anxiety, obsessive-compulsive disorders. Multiple hSERT coding variants have been identified, although to date no comprehensive functional analysis of these has reported. We transfected or 10 examined total surface protein expression, antagonist recognition, transporter modulation by posttranslational, regulatory...
Prior studies have independently reported associations between major depressive disorder (MDD), elevated cortisol concentrations, early adverse events and region-specific decreases in grey matter volume, but the relationships among these variables are unclear. In present study, we sought to evaluate levels MDD.Grey volume was compared 19 controls individuals with MDD using voxel-based morphometry. A history of assessed Childhood Trauma Questionnaire. Subjects also provided salivary samples....
Article Abstract Objective: Specific genetic or biological markers may predict inadequate response to therapy for major depressive disorder (MDD). The objective of the current post hoc analysis was evaluate effect specific and on antidepressant efficacy adjunctive l-methylfolate 15 mg versus placebo from a trial responders selective serotonin reuptake inhibitors (SSRIs). Method: double-blind, randomized, placebo-controlled used sequential parallel comparison design. Outpatients with...
Smith-Lemli-Opitz syndrome (SLOS) is a metabolic and developmental disorder caused by mutations in the gene encoding enzyme 7-dehydrocholesterol reductase (Dhcr7). This catalyzes last step cholesterol biosynthesis, levels of (7-DHC), substrate for this enzyme, are elevated SLOS patients as result defect. Our group has previously shown that 7-DHC extremely prone to free radical autoxidation, we identified about dozen different oxysterols formed from oxidation 7-DHC. We report here...
Mounting evidence indicates that inflammation may play a significant role in the development of depression. Patients with depression exhibit increased inflammatory markers, and administration cytokines other stimuli can induce depressive symptoms. Mechanisms by which access brain influence neurotransmitter systems relevant to have also been described, as preliminary findings indicating antagonizing pathways improve One primary source appears be adiposity. Adipose tissue is rich factors...
We evaluated 20 patients with Cushing's disease (i.e., syndrome due to ACTH-secreting pituitary microadenoma) and Major Depressive Disorder (MDD) using the Structured Clinical Interview for DSM-III-R (SCID) Research Diagnostic Criteria. The diagnosis of Generalized Anxiety (GAD) was most common in (79%), followed by MDD (68%), Panic (PD) including subthreshold PD (53%). combination GAD and/or also (63%). Behavioral symptoms, if present, usually first occurred at or after onset physical...
Depressed patients presenting to emergency departments with acute suicidal ideation are a major public health concern. Ketamine, rapidly acting antidepressant antisuicidal properties, might offer relief.In randomized, double-blind, placebo-controlled, proof-of-concept trial, 18 depressed subjects ideation, who required hospitalization, were randomized either an intravenous ketamine 0.2 mg/kg group or saline placebo group. Safety and efficacy evaluations scheduled for 15, 30, 60, 90, 120,...
Objective: The purpose of this study was to determine the effects antidepressant pharmacotherapy on mood symptoms and psychosocial outcomes in dysthymia.Method: In a multicenter, double-blind, parallel-group trial, 416 patients with diagnosis early-onset primary dysthymia (DSM-III-R) at least 5 years' duration without concurrent major depression were randomly assigned 12 weeks acute-phase therapy sertraline, imipramine, or placebo.The outcome measures used Global Assessment Functioning...
The author's intent was to evaluate the activity of beta-adrenoceptor-linked, cAMP-dependent protein kinase (protein A) in patients with major depression compared a group nondepressed volunteer subjects.Skin fibroblast samples were obtained by 2-mm punch biopsy from 12 (11 women) who had diagnosed according Structured Clinical Interview for DSM-III-R and 10 volunteers (seven women). Fibroblasts cultured Dulbecco's modified Eagle medium. Baseline cAMP-stimulated activities A determined both...
Pimavanserin is a 5-hydroxytryptamine-2A antagonist and inverse receptor agonist. This phase 2 study examined the efficacy safety of pimavanserin as adjunctive therapy in patients with major depressive disorder (MDD).This was multicenter, randomized, double-blind, placebo-controlled DSM-5-defined MDD an inadequate response to selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine (SNRI). Using 2-stage sequential parallel-comparison design, were initially randomized 3:1...
Abstract Major depressive disorder (MDD) is highly prevalent in adolescents and a major risk factor for suicidality. Recent evidence shows that accelerated cellular senescence/aging associated with psychiatric illness, including depression, adults. The present study examined if the relationships of telomere length (TL) mitochondrial DNA copy number (mtDNAcn), two critical indicators senescence/aging, are altered depressed whether these alterations suicidality, early-life adversities, other...
Background The prevalence of depression and obesity among adolescents has markedly increased over the last few decades. A bidirectional relationship been proposed between in adolescence, but it remains poorly understood. Inflammation is a phenomenon that implicated both disorders. Thus, cross-sectional study was designed to investigate inflammation as factor association depression. goal this better understand interplay these two Methods sample consisted female male, black white aged 15–18...