A5088915046- Free Radicals and Antioxidants
- Oxidative Organic Chemistry Reactions
- Radical Photochemical Reactions
- Cholesterol and Lipid Metabolism
- Antioxidant Activity and Oxidative Stress
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Analytical Chemistry and Chromatography
- Organic Chemistry Cycloaddition Reactions
- Catalytic C–H Functionalization Methods
- Porphyrin and Phthalocyanine Chemistry
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Chemical Synthesis and Reactions
- Photochemistry and Electron Transfer Studies
- Lipid metabolism and biosynthesis
- Inorganic and Organometallic Chemistry
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Receptor Mechanisms and Signaling
- Chemical Reactions and Mechanisms
- Synthetic Organic Chemistry Methods
- Inflammatory mediators and NSAID effects
- Fatty Acid Research and Health
Vanderbilt University
2016-2025
John F. Kennedy Center for the Performing Arts
2013-2019
Vanderbilt Health
2019
Institute of Chemical Biology and Fundamental Medicine
2018
Nashville Oncology Associates
2014-2018
Universidad de la República
2010
National Institute of Advanced Industrial Science and Technology
2010
Vanderbilt University Medical Center
2007-2009
Duke University Hospital
1986-2007
Duke Medical Center
1986-2007
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanisms for the autoxidation of polyunsaturated lipidsNed A. PorterCite this: Acc. Chem. Res. 1986, 19, 9, 262–268Publication Date (Print):September 1, 1986Publication History Published online1 May 2002Published inissue 1 September 1986https://doi.org/10.1021/ar00129a001RIGHTS & PERMISSIONSArticle Views1710Altmetric-Citations320LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum full text article downloads since November 2008 (both...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcyclic stereochemical control in free-radical reactionsNed A. Porter, Bernd Giese, and Dennis P. CurranCite this: Acc. Chem. Res. 1991, 24, 10, 296–304Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/ar00010a003https://doi.org/10.1021/ar00010a003research-articleACS PublicationsRequest reuse permissionsArticle Views1408Altmetric-Citations297LEARN...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnified mechanism for polyunsaturated fatty acid autoxidation. Competition of peroxy radical hydrogen atom abstraction, .beta.-scission, and cyclizationNed A. Porter, Laura S. Lehman, Bruce Weber, Karl J. SmithCite this: Am. Chem. Soc. 1981, 103, 21, 6447–6455Publication Date (Print):October 1, 1981Publication History Published online1 May 2002Published inissue 1 October...
The peroxidation of lipids in biological membranes has been implicated both the onset and development most degenerative diseases. primary products this autoxidation process are usually lipid hydroperoxides. They form as a consequence free radical chain reaction: peroxyl radicals propagate by rate-limiting H-atom abstraction from another lipid. Studies mechanism specific part wider effort to understand more general phenomenon hydrocarbon autoxidation, which dates back some 70 years. However,...
The mechanism of formation 4-hydroxy-2E-nonenal (4-HNE) has been a matter debate since it was discovered as major cytotoxic product lipid peroxidation in 1980. Recent evidence points to 4-hydroperoxy-2E-nonenal (4-HPNE) the immediate precursor 4-HNE (Lee, S. H., and Blair, I. A. (2000)Chem. Res. Toxicol. 13, 698–702; Noordermeer, M. A., Feussner, I., Kolbe, Veldink, G. Vliegenthart, J. F. (2000) Biochem. Biophys. Commun.277, 112–116), pathway via 9-hydroperoxylinoleic acid 3Z-nonenal is...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantioselective Free Radical ReactionsMukund P. Sibi and Ned A. PorterView Author Information Department of Chemistry, North Dakota State University, Fargo, 58105, Duke Durham, Carolina 27708, Vanderbilt Nashville, Tennessee 37235 Cite this: Acc. Chem. Res. 1999, 32, 2, 163–171Publication Date (Web):November 19, 1998Publication History Received27 March 1998Published online19 November inissue 1 February...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAutoxidation of polyunsaturated lipids. Factors controlling the stereochemistry product hydroperoxidesNed A. Porter, Bruce Weber, Hugo Weenen, and Jamil KhanCite this: J. Am. Chem. Soc. 1980, 102, 17, 5597–5601Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/ja00537a032https://doi.org/10.1021/ja00537a032research-articleACS PublicationsRequest reuse...
Rate constants for autoxidation propagation of several unsaturated lipids in benzene solution at 37 °C and phosphatidylcholine liposomes were determined by a linoleate radical clock. This clock is based on competition between hydrogen atom abstraction an intermediate peroxyl derived from linoleic acid that leads to trans,cis-conjugated hydroxyoctadecadienoic product β-fragmentation the same gives trans,trans-product acid. this approach relative (kp = 62 M−1 s−1) were: arachidonic 197 ± 13...
Abstract Commercial soybean lipoxygenase may be used under carefully controlled reaction conditions to give high yields of lipid hydroperoxides. Lipid hydroperoxides so derived from γ‐linolenic or arachidonic acid purified by pressure liquid chromatography. Thus, commercial serves as a viable source for 100 mg quantities
Free radicals have been implicated in the pathogenesis of an increasing number diseases. Lipids, which undergo peroxidation, are major targets free radical attack. We report discovery a pathway lipid peroxidation that forms series isomers vivo characterized by substituted tetrahydrofuran ring structure, termed isofurans (IsoFs). proposed two distinct pathways IsoFs can be formed based on 18O2 and H2 18O labeling studies. Measurement F2-isoprostanes (IsoPs), prostaglandin F2-like compounds...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTChiral Lewis Acid Catalysis in Radical Reactions: Enantioselective Conjugate AdditionsMukund P. Sibi, Jianguo Ji, Jason Hongliu Wu, Stephan Gürtler, and Ned A. PorterView Author Information Department of Chemistry North Dakota State University Fargo, 58105 Chemistry, Duke Durham, Carolina 27708 Cite this: J. Am. Chem. Soc. 1996, 118, 38, 9200–9201Publication Date (Web):September 25, 1996Publication History Received12 July 1996Published...
Polyunsaturated fatty acids (PUFA) are primary targets of free radical damage during oxidative stress. Diffusible electrophilic alpha,beta-unsaturated aldehydes, such as 4-hydroxynonenal (HNE), have been shown to modify proteins that mediate cell signaling (e.g., IKK and Keap1) alter gene expression pathways responsible for inducing antioxidant genes, heat shock proteins, the DNA response. To fully understand cellular responses HNE, it is important determine its protein in an unbiased...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and purification of arachidonic acid hydroperoxides biological importanceNed A. Porter, James Logan, Voula KontoyiannidouCite this: J. Org. Chem. 1979, 44, 18, 3177–3181Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/jo01332a017https://doi.org/10.1021/jo01332a017research-articleACS PublicationsRequest reuse permissionsArticle...
Arachidonic acid was co-oxidized by xanthine oxidase.Both superoxide radical and hydrogen peroxide were required for oxidation, as shown essentially complete inhibition caused dismutase or catalase.purr! arachidonate, free of lipid hydroperoxides, susceptible to this eo-oxidation, the presence hydroperoxides did not accelerate process.The role trace metals indicated stimulatory effect EDTA-Fe inhibitory diethylenetriamine pentaacetate.Initiation arachidonate eo-oxidation due a potent oxidant...
Free radical chain oxidation of highly oxidizable 7-dehydrocholesterol (7-DHC), initiated by 2,2′-azobis(4-methoxy-2,4-dimethylvaleronitrile), was carried out at 37 °C in benzene for 24 h. Fifteen oxysterols derived from 7-DHC were isolated and characterized with 1D 2D NMR spectroscopy mass spectrometry. A mechanism that involves abstraction hydrogen atoms C-9 and/or C-14 is proposed to account the formation all reaction progress profile. In either H-9 or H-14 mechanism, a pentadienyl...