A5085105914- Immune Cell Function and Interaction
- Nuclear Receptors and Signaling
- Adenosine and Purinergic Signaling
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
University of Arizona
2019-2021
Autoantibodies play a major pathogenic role in rheumatoid arthritis. T follicular helper (Tfh) cells promote germinal center B cell and Ab responses. Excessive Tfh responses lead to autoimmunity, therefore, counterregulation is crucial. regulatory (Tfr) cells, mainly differentiated from can negatively regulate cells. Dysbiosis involved arthritis's pathogenesis. We previously demonstrated that the gut microbiota, segmented filamentous bacteria (SFB), autoimmune arthritis by inducing However,...
Rheumatoid arthritis (RA) is an autoimmune disease that affects approximately 1% of the world's population. B cells and autoantibodies play important role in pathogenesis RA. The P2RX7 receptor ATP-gated cation channel its activation results release pro-inflammatory molecules. Thus, antagonists have been considered to potential as novel anti-inflammatory therapies. Although originally identified for innate immunity, has recently found negatively control Peyer's patches (PP) T follicular...