A5079176964- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Eosinophilic Esophagitis
- Inflammatory Bowel Disease
- Tryptophan and brain disorders
- CAR-T cell therapy research
- Clostridium difficile and Clostridium perfringens research
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Whipple's Disease and Interleukins
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Bioinformatics and Genomic Networks
- Pluripotent Stem Cells Research
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Pregnancy and Medication Impact
- Chemokine receptors and signaling
- Developmental Biology and Gene Regulation
- Melanoma and MAPK Pathways
- Renal and related cancers
- Microscopic Colitis
Cornell University
2019-2024
Canada's Michael Smith Genome Sciences Centre
2023-2024
Weill Cornell Medicine
2022
University of Arizona
2016-2019
Harvard University
2015
Dana-Farber Cancer Institute
2015
Tsinghua University
2013
Th17 cells accrue in the intestine response to particular microbes. In rodents, segmented filamentous bacteria (SFB) induce intestinal cells, but analogously functioning microbes humans remain undefined. Here, we identified human symbiont bacterial species, Bifidobacterium adolescentis, that could, alone, murine intestine. Similar SFB, B. adolescentis was closely associated with gut epithelium and engendered cognate without attendant inflammation. However, elicited a transcriptional program...
IgA-reactive E. coli in Crohn’s disease–associated spondyloarthritis link mucosal immunity and systemic inflammation.
Group 3 innate lymphoid cells (ILC3s) critically orchestrate host-microbe interactions in the healthy mammalian intestine and become substantially impaired context of inflammatory bowel disease (IBD). However, molecular pathways controlling homeostasis ILC3s remain incompletely defined. Here, we identify that intestinal are highly enriched expression genes involved circadian clock exhibit diurnal oscillations these response to light cues. Classical ILC3 effector functions also exhibited...
Age is an important risk factor for rheumatoid arthritis (RA), which often develops in middle age. However, how age-associated changes immunity impact RA poorly understood. Gut microbiota are known to be involved the pathogenesis of RA, but effects older subjects remain mostly unknown.We used segmented filamentous bacteria (SFB), a gut commensal species with immunomodulatory effects, and K/BxN mice, T cell receptor (TCR) transgenic model, study effect age on autoimmune arthritis. Comparing...
Group 3 innate lymphoid cells (ILC3s) critically regulate host-microbe interactions in the gastrointestinal tract, but their role airway remains poorly understood. Here, we demonstrate that lymphoid-tissue-inducer (LTi)-like ILC3s are enriched lung-draining lymph nodes of healthy mice and humans. These abundantly express major histocompatibility complex class II (MHC II) functionally restrict expansion allergen-specific CD4+ T upon experimental challenge. In a mouse model...
BMP4 maintains self-renewal of mouse embryonic stem cells (ESCs) in collaboration with LIF. Here, we report the identification a novel key BMP target gene, cochlin (Coch) ESCs. Coch can be significantly up-regulated by specifically ESCs but not somatic differentiated cells, and this up-regulation is dependent on signaling mediators Smad1/5 Smad4. Overexpression partially substitute to promote together LIF, whereas knockdown impairs marker gene expression even presence both Further studies...
Rheumatoid arthritis is an autoimmune disorder that affects the joints and other organs. Pulmonary complications contribute significantly to rheumatoid mortality. Retinoic acid its synthetic compound AM80 play roles in immunoregulation but their effect on mucosal autoimmunity remains largely unknown. T follicular helper (Tfh) Th17 cells are known promote inflammation autoantibody production. Using K/BxN model, we elucidate a novel mechanism whereby oral administration suppressed lung...
Group 3 innate lymphoid cells (ILC3s) are abundant in the developing or healthy intestine to critically support tissue homeostasis response microbial colonization. However, intestinal ILC3s reduced during chronic infections, colorectal cancer, inflammatory bowel disease (IBD), and mechanisms driving these alterations remain poorly understood. Here we employed RNA sequencing of from IBD patients observed a significant upregulation RIPK3, central regulator necroptosis, inflammation. This was...
Rheumatoid arthritis (RA) is an autoimmune disease that affects approximately 1% of the world's population. B cells and autoantibodies play important role in pathogenesis RA. The P2RX7 receptor ATP-gated cation channel its activation results release pro-inflammatory molecules. Thus, antagonists have been considered to potential as novel anti-inflammatory therapies. Although originally identified for innate immunity, has recently found negatively control Peyer's patches (PP) T follicular...
Genomic heterogeneity in human cancers complicates gene-centric personalized medicine. Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations. Therefore, one possible solution to overcome the challenge is shift from pathway-centric therapies. Pathway-centric perspectives, which underscore need understand key and their critical properties, could address complexity cancer better than approaches aid drug discovery therapy.We used large-scale...
Current tools for functionally profiling T cell receptors with respect to cytotoxic potency and cross-reactivity are hampered by difficulties in establishing model systems test these proteins the contexts of different HLA alleles against broad arrays potential antigens. We have implemented a granzyme-activatable sensor cytotoxicity universal prototyping platform which enables facile recombinant expression any combination TCR-, peptide-, class I MHC-coding sequences direct assessment...
Abstract Group 3 innate lymphoid cells (ILC3s) respond to microbial colonization of the intestine coordinate tissue health. This process involves interpretation host- or microbial-derived signals that must be tightly regulated preserve immunologic homeostasis. Here we examine a key epigenomic regulator is responsive factors, histone deacetylase (HDAC3), and find lineage-specific deletion results in reduced ILC3s increased susceptibility intestinal damage. In contrast, an essential...
Current tools for functionally profiling T cell receptors with respect to cytotoxic potency and cross-reactivity are hampered by difficulties in establishing model systems test these proteins the contexts of different HLA alleles against broad arrays potential antigens. We have implemented validated a granzyme-activatable sensor cytotoxicity novel universal prototyping platform which enables facile recombinant expression any combination TCR-, peptide-, class I MHC-coding sequences direct...