A5000243815- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Retinal and Optic Conditions
- Gut microbiota and health
- Retinal Imaging and Analysis
- Genetics and Neurodevelopmental Disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cannabis and Cannabinoid Research
- Acne and Rosacea Treatments and Effects
- Viral-associated cancers and disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Endoplasmic Reticulum Stress and Disease
- Monoclonal and Polyclonal Antibodies Research
- Neuroscience of respiration and sleep
- CRISPR and Genetic Engineering
- Nerve injury and regeneration
- Ocular Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Prenatal Substance Exposure Effects
Cornell University
2012-2024
New York Hospital Queens
2023
NewYork–Presbyterian Hospital
2023
MIND Research Institute
2021
Weill Cornell Medicine
2019-2020
Brown University
2017
Yale University
2017
Xi'an Jiaotong University
2017
Sun Yat-sen University
2014-2017
Heightened fear and inefficient safety learning are key features of anxiety disorders. Evidence-based interventions for disorders, such as cognitive behavioral therapy, primarily rely on mechanisms extinction. However, up to 50% clinically anxious individuals do not respond current evidence-based treatment, suggesting a critical need new based alternative neurobiological pathways. Using parallel human rodent conditioned inhibition paradigms alongside brain imaging methodologies, we...
Anxiety disorders peak in incidence during adolescence, a developmental window that is marked by dynamic changes gene expression, endocannabinoid signaling, and frontolimbic circuitry. We tested whether genetic alterations signaling related to common polymorphism fatty acid amide hydrolase (FAAH), which alters anandamide (AEA) levels, would impact the development of circuitry implicated anxiety disorders. In pediatric imaging sample over 1,000 3- 21-y-olds, we show effects FAAH genotype...
Abstract Developmental scientists have examined the independent effects of peer presence, social cues, and rewards on adolescent decision‐making cognitive control. Yet, these contextual factors often co‐occur in real world situations. The current study combined all three control, its underlying neural circuitry, using a task to better capture adolescents' interactions. A sample 176 participants ages 13–25, was scanned while performing an adapted go/no‐go alone or presence virtual peer....
SCN2A, encoding the neuronal voltage-gated Na+ channel NaV1.2, is one of most commonly affected loci linked to autism spectrum disorders (ASDs). Most ASD-associated mutations in SCN2A are loss-of-function mutations, but studies examining how such affect function and whether Scn2a mutant mice display ASD endophenotypes have been inconsistent. We generated a protein truncation variant mouse model (Scn2aΔ1898/+) by CRISPR that eliminates NaV1.2 channel's distal intracellular C-terminal domain,...
A previous study from our group has demonstrated that hydrogen administration can attenuate cardiovascular hypertrophy in vivo by targeting reactive oxygen species‑dependent mitogen‑activated protein kinase signaling. The aim of the present is to determine effect on cardiomyocyte autophagy during β‑adrenoceptor activation and vitro. We prepared hydrogen‑rich medium, concentration was measured using MB‑Pt reagent method. For vitro study, H9c2 cardiomyocytes were stimulated with isoproterenol...
Endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) generation in the brain circumventricular subfornical organ (SFO) mediate central hypertensive actions of Angiotensin II (ANG II). However, downstream signaling events remain unclear. Here we tested hypothesis that angiotensin type 1a receptors (AT R), ER stress, ROS induce activation transcription factor nuclear factor-κB (NF-κB) during ANG II-dependent hypertension. To spatiotemporally track NF-κB activity SFO throughout...
While deep learning has delivered promising results in the field of ophthalmology, hurdle to complete a study is high. In this study, we aim facilitate small scale model trainings by exploring role preprocessing reduce computational burden and accelerate learning.A subset previously published dataset containing optical coherence tomography images choroidal neovascularization, drusen, diabetic macula edema, normal was modified using Fourier transformation bandpass filter, producing high...
Adolescence is a developmental stage in which the incidence of psychiatric disorders, such as anxiety peaks. Selective serotonin reuptake inhibitors (SSRIs) are main class agents used to treat disorders. However, impact SSRIs on developing brain during adolescence remains unknown. The authors assessed developmentally timed SSRI administration genetic mouse model displaying elevated anxiety-like behaviors.
The use of artificial intelligence is becoming more prevalence in medicine with numerous successful examples ophthalmology. However, much the work has been focused on replicating works ophthalmologists. Given analytical potentials intelligence, it plausible that can detect microfeatures not readily distinguished by humans. In this study, we tested potential for to early optic coherence tomography changes predict progression toward papilledema or glaucoma when no significant are detected...
In patients with Epstein-Barr virus (EBV) associated nasopharyngeal carcinoma (NPC), intertumor heterogeneity causes interpatient in the risk of distant metastasis. We aimed to identify novel biomarkers metastasis using reverse phase protein array (RPPA) profiling NPC at for and considering plasma EBV DNA load.A total 98 without after treatment, matched respect clinical parameters, are enrolled. Total expression is measured by RPPA, functions analyzed pathway bioinformatics.The RPPA analysis...
Pediatric obesity is a major public health concern. Genetic susceptibility and increased availability of energy-dense food are known risk factors for obesity. However, the extent to which these jointly bias behavior neural circuitry towards adiposity in children remains unclear. While undergoing fMRI, 108 (ages 5-11y) performed food-specific go/no-go task. Participants were instructed either respond ("go") or inhibit responding ("no-go") images toys. Half runs depicted high-calorie foods...
A 54-year-old woman presented with a 30-year history of worsening left blepharoptosis. Neuro-ophthalmic examination was significant for blepharoptosis, limited levator function, and supraduction in the eye hypotropia, normal pupils without diplopia. MRI brain/orbits revealed subtle atrophy superior rectus (figure 1, B), any orbital pathology. Superior compression oculomotor nerve by posterior cerebral artery (PCA) observed C–E). Given microanatomy cistern space,1,2 this is rare selective...
We recently showed that NF‐κB is activated in the SFO of brain during slow‐pressor Ang‐II hypertension (HTN). The molecular mechanisms contributing to activation, however, remain unclear. tested hypothesis activation HTN mediated by AT 1a receptors and ROS. Male flox mice underwent SFO‐targeted injections an adenovirus encoding firefly luciferase downstream response elements, conjunction with adenoviral delivery Cre‐recombinase (Cre) for selective deletion or control LacZ. After recovery,...