A5003508094- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Eating Disorders and Behaviors
- Attention Deficit Hyperactivity Disorder
- Substance Abuse Treatment and Outcomes
- Biochemical Analysis and Sensing Techniques
- Multisensory perception and integration
- Advanced Neuroimaging Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Cognitive Abilities and Testing
- Neuroscience and Music Perception
- Neurotransmitter Receptor Influence on Behavior
- Advanced MRI Techniques and Applications
- Olfactory and Sensory Function Studies
- Health, Environment, Cognitive Aging
- Neonatal and fetal brain pathology
- Nutrition, Genetics, and Disease
- Consumer Attitudes and Food Labeling
- Birth, Development, and Health
- Psychedelics and Drug Studies
- Social and Intergroup Psychology
Yale University
2018-2023
Dartmouth College
2015-2019
National Institute of Mental Health
2013
National Institutes of Health
2013
West Virginia University
2011
Abstract The modern understanding of sleep is based on the classification into stages defined by their electroencephalography (EEG) signatures, but underlying brain dynamics remain unclear. Here we aimed to move significantly beyond current state-of-the-art description sleep, and in particular characterise spatiotemporal complexity whole-brain networks state transitions during sleep. In order obtain most unbiased estimate how network states evolve through human cycle, used a Markovian...
The vmPFC ascribes affective meaning to experiences as they unfold and exhibits unique idiographic spatiotemporal dynamics.
Obesity is a major public health concern that involves an interaction between genetic susceptibility and exposure to environmental cues (e.g., food marketing); however, the mechanisms link these factors contribute unhealthy eating are unclear. Using well-known obesity risk polymorphism (FTO rs9939609) in sample of 78 children (ages 9-12 y), we observed at for exhibited stronger responses commercials nucleus accumbens (NAcc) than not risk. Similarly, higher demonstrated larger NAcc volumes....
Abstract Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” connectivity (FC). Knowing that FC constantly evolves over time, it becomes important assess how dynamically differs in remitted‐MDD patients vulnerable for new episodes. Using a recently developed method examine dynamic FC, we characterized re‐emerging states during rest 51 antidepressant‐free MDD at high...
Abstract The Adolescent Brain Cognitive Development Study (ABCD), a 10 year longitudinal neuroimaging study of the largest population based and demographically distributed cohort 9-10 olds (N=11,877), was designed to overcome reproducibility limitations prior child mental health studies. Besides fantastic wealth research opportunities, extremely large size ABCD data set also creates enormous storage, processing, analysis challenges for researchers. To ensure privacy safety, researchers are...
Working memory function changes across development and varies individuals. The patterns of behavior brain that track individual differences in working during human development, however, are not well understood. Here, we establish associations between memory, other cognitive abilities, functional MRI (fMRI) activation data from over 11,500 9- to 10-year-old children (both sexes) enrolled the Adolescent Brain Cognitive Development (ABCD) Study, an ongoing longitudinal study United States....
Aim To examine individual variability between perceived physical features and hormones of pubertal maturation in 9–10-year-old children as a function sociodemographic characteristics. Methods Cross-sectional metrics puberty were utilized from the baseline assessment Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample 9–10 year-olds (n = 11,875)—and included via development scale (PDS) child salivary hormone levels (dehydroepiandrosterone testosterone all, estradiol...
The prevalence of adolescent obesity has increased dramatically over the past three decades, and research documented that number television shows viewed during childhood is associated with greater risk for obesity. In particular, considerable evidence suggests exposure to food marketing promotes eating habits contribute present study examines neural responses dynamic commercials in overweight healthy-weight adolescents using functional magnetic resonance imaging (fMRI). Compared non-food...
The prevalence of obesity in children and adolescents worldwide has quadrupled since 1975 is a key predictor later life. Previous work consistently observed relationships between macroscale measures reward-related brain regions (e.g., the nucleus accumbens [NAcc]) unhealthy eating behaviors outcomes; however, mechanisms underlying these associations remain unclear. Recent highlighted potential role neuroinflammation NAcc animal models diet-induced obesity. Here, we leverage diffusion MRI...
Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to requiring urgent medical intervention. In the case of brain magnetic resonance (MRI), reliable data about prevalence significance IFs in general population limited, making it difficult anticipate, communicate, manage these findings.To determine overall MRI nonclinical pediatric as well rates specific for which clinical referral is recommended.This cohort study was...
How has the public responded to increasing prevalence of artificial intelligence (AI)-based technologies? We investigate perceptions AI by collecting over 12,000 responses 12 months from a nationally representative U.S. sample. Participants provided open-ended metaphors reflecting their mental models AI, methodology that overcomes limitations traditional self-reported measures. Using mixed-methods approach combining quantitative clustering and qualitative coding, we identify 20 dominant...
Abstract How we process ongoing experiences is shaped by our personal history, current needs, and future goals. Consequently, brain regions involved in generating these subjective appraisals, such as the vmPFC, often appear to be heterogeneous across individuals even response same external information. To elucidate role of vmPFC processing experiences, developed a computational framework analysis pipeline characterize spatiotemporal dynamics individual responses participants viewed 45-minute...
The prevalence of risky behavior such as substance use increases during adolescence; however, the neurobiological precursors to adolescent remain unclear. Predictive modeling may complement previous work observing associations with known risk factors or outcomes by developing generalizable models that predict early susceptibility. aims current study were identify and characterize behavioral brain vulnerability future use. Principal components analysis (PCA) used together connectome-based...
Abstract Exposure to socioeconomic disadvantages (SED) can have negative impacts on mental health, yet SED are a multifaceted construct and the precise processes by which confer deleterious effects less clear. Using large diverse sample of preadolescents (ages 9–10 years at baseline, n = 4038, 49% female) from Adolescent Brain Cognitive Development Study, we examined associations among both household (i.e., income–needs material hardship) neighborhood area deprivation unsafety) levels,...
In this study, we assess whether activation of the brain's reward system in response to alcohol advertisements is associated with college drinking. Previous research has established a relationship between exposure marketing and underage Within other appetitive domains, cue behavioral enactment known rely on system. However, neural consumption not been studied nondisordered population.
Abstract The endocannabinoid system is an important regulator of emotional responses such as fear, and a number studies have implicated signaling in anxiety. fatty acid amide hydrolase (FAAH) C385A polymorphism, which associated with enhanced the brain, has been identified across species potential protective factor from In particular, adults variant FAAH 385A allele greater fronto‐amygdala connectivity lower anxiety symptoms. Whether broader network‐level differences exist, when during...
Both sighted and blind individuals can readily interpret meaning behind everyday real-world sounds. In listeners, we previously reported that regions along the bilateral posterior superior temporal sulci (pSTS) middle gyri (pMTG) are preferentially activated when presented with recognizable action These have generally been hypothesized to represent primary loci for complex motion processing, including visual biological processing audio-visual integration. However, it remained unclear...
Numerous species possess cortical regions that are most sensitive to vocalizations produced by their own kind (conspecifics). In humans, the superior temporal sulci (STSs) putatively represent homologous voice-sensitive areas of cortex. However, sulcus (STS) have recently been reported auditory experience or “expertise” in general rather than showing exclusive sensitivity human per se. Using functional magnetic resonance imaging and a unique non-stereotypical category complex non-verbal...
Several public health departments throughout North America have responded to the obesity epidemic by mandating that restaurants publish calories at point of purchase-with intention encouraging healthier food decisions. To help determine whether accompanying calorie information successfully changes a food's appetitive value, this study investigated influence on brain responses images. During functional magnetic resonance imaging (fMRI) scanning, dieting (N = 22) and non-dieting 20)...