A5002410528- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Neurological disorders and treatments
- Nicotinic Acetylcholine Receptors Study
- Dementia and Cognitive Impairment Research
- Mental Health Research Topics
- Schizophrenia research and treatment
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Child and Adolescent Psychosocial and Emotional Development
- Heart Rate Variability and Autonomic Control
- Traumatic Brain Injury and Neurovascular Disturbances
- Gambling Behavior and Treatments
- Substance Abuse Treatment and Outcomes
- Attention Deficit Hyperactivity Disorder
- Visual perception and processing mechanisms
- Receptor Mechanisms and Signaling
- Fetal and Pediatric Neurological Disorders
University of Colorado Anschutz Medical Campus
2013-2025
University of Colorado Denver
2014-2025
University of Nebraska Medical Center
2025
Imaging Center
2024
Mayo Clinic
2024
University College London
2024
Icahn School of Medicine at Mount Sinai
2024
University of Virginia Health System
2024
American Society of Neuroradiology
2024
Oregon Health & Science University
2024
This article describes a 3-year experience with focal neocortical ischemia in three rat strains. Multiple groups of adult Wistar (n = 50), Fisher 344 31), and spontaneously hypertensive 72) rats were subjected to permanent occlusion the distal middle cerebral (MCA) ipsilateral common carotid arteries (CCA). Twenty-four hours later animals killed, frozen brain sections stained hematoxylin eosin demarcate infarcted tissue. The infarct volume for each section was quantified an image analyzer,...
Poor decision-making is a hallmark of addiction, whether to substances or activities. Performance on widely used test decision-making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance-dependence, and pathological gambling. Positron emission tomography (PET) studies indicate that substance-dependent individuals show altered prefrontal activity task. Here we adapted IGT an fMRI setting hypothesis defects in processing are...
Importance Cannabis use has increased globally, but its effects on brain function are not fully known, highlighting the need to better determine recent and long-term activation outcomes of cannabis use. Objective To examine association lifetime history heavy with across a range functions in large sample young adults US. Design, Setting, Participants This cross-sectional study used data (2017 release) from Human Connectome Project (collected between August 2012 2015). Young (aged 22-36 years)...
Article abstract <b><i>Background:</i></b> The cause of dementia in subcortical ischemic vascular disease (SIVD) is controversial. <b><i>Objectives:</i></b> To determine whether cognitive impairment SIVD 1) correlates with measures brain injury or atrophy, and/or 2) due to concomitant AD. <b><i>Methods:</i></b> Volumetric MRI the was performed elderly subjects lacunes (L) and a spectrum impairment—normal cognition (NC+L, n = 32), mild (CI+L, 26), (D+L, 29); comparison group probable AD (n...
We investigated the temporal threshold for focal cerebral infarction in spontaneously hypertensive rat. The right middle artery and common carotid were occluded 0, 1, 2, 3, 4, or 24 hours, all animals sacrificed hours after onset of ischemia. Cortical infarct volumes edema quantified serial frozen sections hematoxylin eosin-stained tissue using image analysis. Upon occlusion, blood flow core ischemic zone, measured with laser-Doppler flowmetry, fell to a mean +/- standard deviation 21 7%...
We examined the relationships between intracellular pH (pHi) and interstitial (pHe) in a rat model of focal ischemia. Interstitial was measured with pH-sensitive microelectrodes, average tissue [14C]dimethadione method rats subjected to occlusion right middle cerebral common carotid arteries (MCA-CCAO). In normal cortex, pHe pHi were 7.24 +/- 0.97 7.01 0.13 (means SD, n = 6), respectively. ischemic fell 6.43 0.13, whereas decreased only 6.86 0.11 (n 5) 1 h after MCA-CCAO. After 4 ischemia,...
Hippocampal atrophy detected by MRI is a prominent feature of early Alzheimer9s disease (AD), but it likely that underestimates the degree hippocampal neuron loss, because reactive gliosis attenuates atrophy. We tested hypothesis N-acetyl aspartate (NAA; neuronal marker) and volume used together provide greater discrimination between AD normal elderly than does either measure alone. proton MR spectroscopic imaging (<sup>1</sup>H MRSI) tissue segmented volumetric images to atrophy-corrected...
The regulation of energy intake is a complex process involving the integration homeostatic signals and both internal external sensory inputs. To better understand neurobiology this how it may be dysfunctional in obesity, study examined activity brain's "default network" reduced-obese (RO) as compared to lean individuals. default network group functionally connected brain regions thought play an important role internally directed cognitive interplay between processing. Functional magnetic...
Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to requiring urgent medical intervention. In the case of brain magnetic resonance (MRI), reliable data about prevalence significance IFs in general population limited, making it difficult anticipate, communicate, manage these findings.To determine overall MRI nonclinical pediatric as well rates specific for which clinical referral is recommended.This cohort study was...
We thank Dirk Smeets for his interest in our article and AJNR the opportunity to respond. Regarding sample size, study is line with previous work comparing effect of a report no on accuracy among clinical readers. Our had same or more cognitively healthy (CN)
Herpes simplex virus (HSV)–1 encephalitis has an incidence of one to four cases per million people year and accounts for up 20% all encephalitides. High morbidity mortality without treatment underscores the importance early diagnosis therapy. CSF PCR analysis is gold standard diagnosis, with high sensitivity specificity.1 In addition PCR, profile pattern MRI abnormalities are also important clues HSV encephalitis. On MRI, T2 hyperintensities in medial temporal inferior frontal lobes...
Smooth pursuit eye movements are abnormal in patients with schizophrenia. The investigators used functional magnetic resonance imaging (fMRI) to compare brain hemodynamic response during a smooth movement task schizophrenia and healthy comparison subjects.Fourteen 14 subjects performed while undergoing 1.5-T fMRI. Echo-planar images from the blocked design were evaluated both whole-brain random-effects analysis region-of-interest analysis. deficits assessed outside fMRI apparatus by using...
Focal cerebral infarction and edema were measured in rats (Wistar, Fisher 344, spontaneously hypertensive strains) pretreated with nimodipine (2 micrograms/kg/min i.v.) or its vehicle subjected to the tandem occlusion of middle common carotid arteries. Animals awoke from anesthesia 10-15 min after onset ischemia continued receive treatment over a 24-h survival period. Cortical quantified by image analysis frozen brain sections processed for histology. Nimodipine-treated developed 20-60%...