Elizabeth A. Hoffman
A5043584290- Genomics and Chromatin Dynamics
- Health, Environment, Cognitive Aging
- RNA Research and Splicing
- Child and Adolescent Psychosocial and Emotional Development
- DNA Repair Mechanisms
- Functional Brain Connectivity Studies
- Ethics in Clinical Research
- RNA and protein synthesis mechanisms
- Neuroethics, Human Enhancement, Biomedical Innovations
- Early Childhood Education and Development
- Advanced MRI Techniques and Applications
- Birth, Development, and Health
- Impact of Technology on Adolescents
- Genetics and Neurodevelopmental Disorders
- Ocular Oncology and Treatments
- Child Development and Digital Technology
- Advanced Neuroimaging Techniques and Applications
- Face Recognition and Perception
- Sex and Gender in Healthcare
- Child Abuse and Trauma
- Genomic variations and chromosomal abnormalities
- Parkinson's Disease Mechanisms and Treatments
- LGBTQ Health, Identity, and Policy
- Analytical Chemistry and Chromatography
- Mesenchymal stem cell research
National Institute on Drug Abuse
2018-2025
National Institutes of Health
1997-2024
University of Virginia Health System
2014-2024
University of California, San Diego
2019-2024
University of Michigan–Ann Arbor
2024
SUNY Upstate Medical University
2011-2022
University of Indianapolis
2020
Children's Mercy Hospital
2019
The Ohio State University
2018
Adler
2017
Mutations in ATP13A2 (PARK9), encoding a lysosomal P-type ATPase, are associated with both Kufor-Rakeb syndrome (KRS) and neuronal ceroid lipofuscinosis (NCL). KRS has recently been classified as rare genetic form of Parkinson's disease (PD), whereas NCL is storage disorder. Although the transport activity not defined, vitro studies show that its loss compromises function, which turn thought to cause degeneration. To understand role dysfunction disease, we disrupted gene mice. Atp13a2(-/-)...
Abstract Sensory information from mechanoreceptors and nociceptors in the skin plays key roles adaptive protective motor behaviours. To date, very little is known about how this encoded by spinal cord cell types their activity patterns, particularly under freely behaving conditions. enable stable measurement of neuronal glial mice, we have developed fluorescence imaging approaches based on two- miniaturized one-photon microscopy. We show that distinct cutaneous stimuli activate overlapping...
The Adolescent Brain Cognitive Development (ABCD) Study, a large, longitudinal study of brain development and child health, is uniquely positioned to explore relationships among stress, neurodevelopment, psychiatric symptomatology, including substance use addiction. There much we do not know about how adverse experiences affect the developing cognitive, social, emotional, academic outcomes. data collected by ABCD Study will allow examination these variables in adolescence, effects stressors...
Abstract The Adolescent Brain Cognitive Development Study (ABCD), a 10 year longitudinal neuroimaging study of the largest population based and demographically distributed cohort 9-10 olds (N=11,877), was designed to overcome reproducibility limitations prior child mental health studies. Besides fantastic wealth research opportunities, extremely large size ABCD data set also creates enormous storage, processing, analysis challenges for researchers. To ensure privacy safety, researchers are...
Aim To examine individual variability between perceived physical features and hormones of pubertal maturation in 9–10-year-old children as a function sociodemographic characteristics. Methods Cross-sectional metrics puberty were utilized from the baseline assessment Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample 9–10 year-olds (n = 11,875)—and included via development scale (PDS) child salivary hormone levels (dehydroepiandrosterone testosterone all, estradiol...
The Adolescent Brain Cognitive DevelopmentSM (ABCD) study is a longitudinal of adolescent brain development and health that includes over 11,800 youth in the United States. ABCD broad developmental domains, gender sexuality are two these with noted changes across late childhood early adolescence. Gender Identity Sexual Health (GISH) workgroup recommends measures for study, prioritizing those developmentally sensitive, capture individual differences experience sexuality, minimize participant...
We have previously demonstrated that in Saccharomyces cerevisiae replication, checkpoint inactivation via a mec1 mutation leads to chromosome breakage at replication forks initiated from virtually all origins after transient exposure hydroxyurea (HU), an inhibitor of ribonucleotide reductase. Here we sought determine whether containing single-stranded DNA gaps equal probability producing double-strand breaks (DSBs) when cells attempt recover HU exposure. devised new methodology, Break-seq,...
There are known associations between mental health symptoms and transgender identity among adults. Whether this relationship extends to early adolescents gender domains other than is unclear. This study measured dimensions of in a large, diverse, sample youth, examined diverse experiences health.
Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to requiring urgent medical intervention. In the case of brain magnetic resonance (MRI), reliable data about prevalence significance IFs in general population limited, making it difficult anticipate, communicate, manage these findings.To determine overall MRI nonclinical pediatric as well rates specific for which clinical referral is recommended.This cohort study was...
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, emotional development beginning prenatally planned through early childhood. Study success depends on the engagement inclusion of diverse populations pregnant participants their children across United States, including those at high low risk for prenatal substance use. Communications, Engagement, Dissemination (CED) Committee is...
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene and deficiency of functional FMRP protein. known as translation repressor whose nuclear function not understood. We investigated global impact on genome stability due to loss. Using Break-seq, we map spontaneous replication stress-induced DNA double-strand breaks (DSBs) an FXS patient-derived cell line. report that genomes cells are inherently unstable accumulate twice many DSBs those from...
Abstract The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children’s health in United States. A cohort n= 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites are being followed with in-person visits on an annual basis for at least 10 years. approximates US population several key sociodemographic variables, including sex, race, ethnicity, household income,...