A5012426973- Functional Brain Connectivity Studies
- Cognitive Abilities and Testing
- Genetic Associations and Epidemiology
- Attention Deficit Hyperactivity Disorder
- Birth, Development, and Health
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Psychosomatic Disorders and Their Treatments
- Health, Environment, Cognitive Aging
- Action Observation and Synchronization
- EEG and Brain-Computer Interfaces
- Digital Mental Health Interventions
- Neural dynamics and brain function
- Motor Control and Adaptation
- Early Childhood Education and Development
- Infant Development and Preterm Care
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Neural and Behavioral Psychology Studies
- Trace Elements in Health
- Bioinformatics and Genomic Networks
- Iron Metabolism and Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Maternal Mental Health During Pregnancy and Postpartum
University of California, San Diego
2019-2025
NHS Digital
2025
University College London
2015-2021
University of Wisconsin–Milwaukee
2021
ORCID
2021
Royal Holloway University of London
2018-2019
University of Oxford
2015-2018
Sobell House
2015-2018
Wellcome Centre for Integrative Neuroimaging
2018
University of Birmingham
2014
Sensory attenuation, the top-down filtering or gating of afferent information, has been extensively studied in two fields: physiological and perceptual. Physiological sensory attenuation is represented as a decrease amplitude primary secondary components somatosensory evoked potential (SEP) before during movement. Perceptual described using analogy persons' inability to tickle oneself, reduction perception input self-produced tactile sensation due central cancellation reafferent signal by...
Brain morphology has been shown to be highly heritable, yet only a small portion of the heritability is explained by genetic variants discovered so far. Here we extended Multivariate Omnibus Statistical Test (MOSTest) and applied it genome-wide association studies (GWAS) vertex-wise structural magnetic resonance imaging (MRI) cortical measures from N=35,657 participants in UK Biobank. We identified 695 loci for surface area 539 thickness, total 780 unique associated with robustly replicated...
Aim To examine individual variability between perceived physical features and hormones of pubertal maturation in 9–10-year-old children as a function sociodemographic characteristics. Methods Cross-sectional metrics puberty were utilized from the baseline assessment Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample 9–10 year-olds (n = 11,875)—and included via development scale (PDS) child salivary hormone levels (dehydroepiandrosterone testosterone all, estradiol...
The Adolescent Brain Cognitive Development (ABCD) Study of 11,880 youth incorporates a comprehensive range measures assessing predictors and outcomes related to mental health across childhood adolescence in participating youth, as well information about family history. We have previously described the logic content assessment battery at Baseline 1-year follow-up. Here, we describe changes that issues clarifications emerged, additions 2-, 3-, 4-, 5-year follow-ups. capitalize on recent...
During late childhood behavioral changes, such as increased risk-taking and emotional reactivity, have been associated with the maturation of cortico-cortico cortico-subcortical circuits. Understanding microstructural changes in both white matter subcortical regions may aid our understanding how individual differences these behaviors emerge. Restriction spectrum imaging (RSI) is a framework for modelling diffusion-weighted that decomposes diffusion signal from voxel into hindered,...
Abstract The linear mixed‐effects model (LME) is a versatile approach to account for dependence among observations. Many large‐scale neuroimaging datasets with complex designs have increased the need LME; however LME has seldom been used in whole‐brain imaging analyses due its heavy computational requirements. In this paper, we introduce fast and efficient algorithm (FEMA) that makes vertex‐wise, voxel‐wise, connectome‐wide large samples possible. We validate FEMA extensive simulations,...
A number of empirical and theoretical reports link altered interoceptive processing to anxiety. However, the mechanistic understanding relationship between two remains poor. We propose that a heightened sensibility for signals, combined with difficulty in attributing these sensations emotions, increases an individual's vulnerability In order investigate this, large sample general population adults were recruited completed self-report measures sensibility, trait anxiety alexithymia. Results...
While low socioeconomic status (SES) introduces risk for developmental outcomes among children, there are an array of proximal processes that determine the ecologies and thus lived experiences children. This study examined interrelations between 22 measures in economic, psychosocial, physiological, perinatal association with brain structure cognitive performance a diverse sample 8,158 9-10-year-old children from Adolescent Brain Cognitive Development (ABCD) study. SES was measured by...
Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to requiring urgent medical intervention. In the case of brain magnetic resonance (MRI), reliable data about prevalence significance IFs in general population limited, making it difficult anticipate, communicate, manage these findings.To determine overall MRI nonclinical pediatric as well rates specific for which clinical referral is recommended.This cohort study was...
Despite its central role in revealing the neurobiological mechanisms of behavior, neuroimaging research faces challenge producing reliable biomarkers for cognitive processes and clinical outcomes. Statistically significant brain regions, identified by mass univariate statistical models commonly used studies, explain minimal phenotypic variation, limiting translational utility phenotypes. This is potentially due to observation that behavioral traits are influenced variations phenotypes...
<h3>Importance</h3> Outdoor particulate matter 2.5 μm or less in diameter (PM<sub>2.5</sub>) is a ubiquitous environmental neurotoxicant that may affect the developing brain. Little known about associations between PM<sub>2.5</sub>and white connectivity. <h3>Objectives</h3> To assess annual residential PM<sub>2.5</sub>exposure and microstructure health US sample of children 9 to 10 years age examine whether are specific certain pathways vary across neuroimaging diffusion markers reflective...
Digital mental health interventions, such as artificial intelligence (AI) conversational agents, hold promise for improving access to care by innovating therapy and supporting delivery. However, little research exists on patient perspectives regarding AI which is crucial their successful implementation. This study aimed fill the gap exploring patients' perceptions acceptability of agents in healthcare. Adults with self-reported mild moderate anxiety were recruited from UMass Memorial Health...
Background. Prevalence rates for anxiety and depression are increasing globally, outpacing the capacity of traditional mental health services. Digital Mental Health Interventions (DMHIs) offer a cost-effective solution, but user engagement is poor. Integrating AI-powered conversational agents could enhance experience, though AI technology rapidly evolving, acceptability these solutions remains uncertain. Objective. This study aims to understand acceptability, usability agent-led DMHI with...
Results of the impact reading books and viewing television on neurodevelopment have been mixed, without definitive evaluation to date. Using data from 11,875 US adolescents in Adolescent Brain Cognitive Development (ABCD) study, we investigated associations between brain morphology neurocognitive performance. After quality control, 8,125 participants' MRI scans cognitive tests were analyzed relation their TV habits. Greater time was associated with higher performance regionally-selective...
Spatial and temporal expectations act synergistically to facilitate visual perception. In the current study, we sought investigate anticipatory oscillatory markers of combined spatial-temporal orienting test whether these decline with ageing. We examined neural dynamics associated joint attention using magnetoencephalography (MEG) in both younger older adults. Participants performed a cued covert task requiring discrimination target. Cues indicated where when targets would appear. age...
It has been proposed that motor system activity during action observation may be modulated by the kinematics of observed actions. One purpose this to predict visual consequence another person's based on their movement kinematics. Here, we tested hypothesis primary cortex (M1) have a causal role in inferring information is present Healthy participants completed an perception task before and after applying continuous theta burst stimulation (cTBS) over left M1. A neurophysiological marker was...
Abstract The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children’s health in United States. A cohort n= 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites are being followed with in-person visits on an annual basis for at least 10 years. approximates US population several key sociodemographic variables, including sex, race, ethnicity, household income,...