A5034065168- Bipolar Disorder and Treatment
- Birth, Development, and Health
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Health disparities and outcomes
- Toxoplasma gondii Research Studies
- Health, Environment, Cognitive Aging
- Attention Deficit Hyperactivity Disorder
- Tryptophan and brain disorders
- Autoimmune Neurological Disorders and Treatments
- Celiac Disease Research and Management
- Epigenetics and DNA Methylation
- Obsessive-Compulsive Spectrum Disorders
- Epilepsy research and treatment
- Mental Health Research Topics
- Psychosomatic Disorders and Their Treatments
- Hemoglobinopathies and Related Disorders
- Herpesvirus Infections and Treatments
- Air Quality and Health Impacts
- Diabetes and associated disorders
- Adolescent and Pediatric Healthcare
Aarhus University
2014-2024
Lundbeck Foundation
2014-2023
Glostrup Hospital
2023
Aarhus University Hospital
2017
Statens Serum Institut
2011
Roskilde Sygehus
2007-2009
Most societies believe that a mother's psychological state can influence her unborn baby. Severe adverse life events during pregnancy have been consistently associated with an elevated risk of low birth weight and prematurity. Such the first trimester also congenital malformations.To assess effect in offspring antenatal maternal exposure to objective measure stress on neurodevelopment, specifically schizophrenia. We hypothesized strongest relationship would be exposures...
Recent studies suggest that familial autoimmunity plays a part in the pathogenesis of ASDs. In this study we investigated association between family history autoimmune diseases (ADs) and ASDs/infantile autism. We perform confirmatory analyses based on results from previous studies, as well various explorative analyses.The cohort consisted all children born Denmark 1993 through 2004 (689 196 children). Outcome data both inpatient outpatient diagnoses reported to Danish National Psychiatric...
The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. iPSYCH2012 is nested within entire population born between 1981 2005, including 1 472 762 persons. This paper introduces outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146),...
<h3>Importance</h3> Anxiety and stress-related disorders are among the most common mental disorders. Although family twin studies indicate that both genetic environmental factors play an important role underlying their etiology, underpinnings of anxiety poorly understood. <h3>Objectives</h3> To estimate single-nucleotide polymorphism–based heritability disorders; to identify novel risk variants, genes, or biological pathways; test for pleiotropic associations with other psychiatric traits;...
Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior. This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify who a diagnosis (N = 2591), attempted or committed suicide 655), had traffic accidents 2724). For all cases, controls were frequency matched by age sex, resulting in 11,546 participants. Plasma samples analyzed for immunoglobulin G (IgG) antibodies against...
Context: Studies linking birth weight and mental illness onset are inconclusive.They have primarily focused on the World Health Organization low threshold (2500 g) schizophrenia.To our knowledge, per se has not been conclusively linked with schizophrenia risk specificity of effect to below standard or particular psychiatric diagnoses demonstrated.Objectives: To examine whether (1) (Ͻ2500 is associated increased for adult schizophrenia; (2) extends into normal range; (3) confined other...
Two studies based on clinical samples have found an association between Toxoplasma gondii infection and history of suicide attempt. To our knowledge, these findings never been replicated in a prospective cohort study.To examine whether T gondii–infected mothers increased risk self-directed violence, violent attempts, the depends level IgG antibodies.Register-based study. Women were followed up from date delivery, 1992 to 1995 until 2006.Denmark.A 45 788 women born Denmark whose...
Previous research has found an increased risk of schizophrenia in individuals with autoimmune diseases and smaller but significant associations a family history diseases. This study investigates, for the first time, association between subsequent (the reverse temporality) also considers effect infections, possible factor both diseases.Danish nationwide registers were linked to establish cohort 3.83 million people, identifying 39,364 schizophrenia-like psychosis 142,328 disease. Data analyzed...
A family history of schizophrenia is the strongest single indicator individual risk. Bipolar affective disorder and schizo-affective disorders have been documented to occur more frequently in parents siblings patients, but familial occurrence broader range mental illnesses their role as confounders not studied large population-based samples.All people born Denmark between 1955 1991 (1.74 million) were followed for development (9324 cases) during 28 million person-years at Information cohort...
Despite a remarkable co-occurrence of obsessive-compulsive disorder (OCD) and schizophrenia, little is known about the clinical etiological relationship these 2 disorders. Exploring degree to which disorders share factors might provide useful implications for clinicians, researchers, those with disorders.To assess whether patients OCD experience an enhanced risk developing schizophrenia spectrum determine family history constitutes factor disorders.Using individual data from longitudinal...
Abstract The Lundbeck Foundation Integrative Psychiatric Research (iPSYCH) consortium has almost doubled its Danish population-based Case–Cohort sample (iPSYCH2012). newly updated cohort, named iPSYCH2015, expands the study base with 56,233 samples, to a combined total of 141,265 samples. cohort is nested within population born between 1981 and 2008 Case-Cohort design including 50,615 controls. We added more cases existing phenotypes identified with, schizophrenia (N new =4,131/N =8,113),...
Objective: To investigate the association between maternal exposure to severe life events and fetal growth (birthweight small for gestational age). Stress has been associated with adverse pregnancy outcome. Methods: Mothers of 1.38 million singleton live births in Denmark January 1, 1979 December 31, 2002 were linked information on their spouses, parents, siblings, older children. Exposure was defined as death or serious illness a relative during 6 months before conception. Linear regression...
BACKGROUNDAdverse pregnancy outcomes have been associated with maternal celiac disease (CD). In this study, we investigate the effect of treated and untreated CD on infant birthweight preterm birth.
Several studies based on clinical samples have found an association between Toxoplasma gondii infection and schizophrenia, a case-control study among U.S. military personnel with specimens available from both before after diagnosis positive T. immunoglobulin G (IgG) antibody level schizophrenia. These findings never been replicated in prospective cohort study. The purpose of this was to determine whether mothers infected elevated risk schizophrenia or related disorders the depends IgG...
Abstract Bipolar disorder (BD) is a heritable mental illness with complex etiology. We performed genome-wide association study (GWAS) of 41,917 BD cases and 371,549 controls European ancestry, which identified 64 associated genomic loci. risk alleles were enriched in genes synaptic signaling pathways brain-expressed genes, particularly those high specificity expression neurons the prefrontal cortex hippocampus. Significant signal enrichment was found encoding targets antipsychotics, calcium...
<h3>Background, Methods and Objectives</h3> Maternal autoantibodies to neuronal proteins may be one cause of neurodevelopmental disorders. This exploratory study used the Danish archived midgestational sera their nationwide registers search for antibodies N-methyl-D-aspartate receptor (NMDAR) contactin-associated protein-like 2 (CASPR2) in maternal sera, relate them subsequent psychiatric diagnoses woman or her child. <h3>Results</h3> In a sample 192 women, there was no association between...
It is not possible to fully assess intention of self-harm and suicidal events using information from administrative databases. We conducted a validation study suicide attempts/self-harm contacts identified by commonly applied Danish register-based algorithm (DK-algorithm) based on hospital discharge diagnosis emergency room contacts.Of all 101 530 people with an incident attempt/self-harm contact at hospitals between 1995 2012 the DK-algorithm, we selected random sample 475 people. validated...
Urban-rural differences in schizophrenia risk have been widely evidenced across Western countries. However, explanation of these is lacking. We aimed to identify contextual factors for that explain urban-rural risk.