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A5088477364- Bipolar Disorder and Treatment
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Adolescent and Pediatric Healthcare
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Child and Adolescent Psychosocial and Emotional Development
- Electrolyte and hormonal disorders
- Tryptophan and brain disorders
- Growth Hormone and Insulin-like Growth Factors
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Child Nutrition and Feeding Issues
- Nursing care and research
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Immune Cell Function and Interaction
- Patient Satisfaction in Healthcare
- Maternal Mental Health During Pregnancy and Postpartum
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Asthma and respiratory diseases
- Genomic variations and chromosomal abnormalities
- Stress and Burnout Research
McGill University Health Centre
2016-2025
Harvard University
2025
Montreal Neurological Institute and Hospital
2016-2024
McGill University
2010-2022
Genomics (United Kingdom)
2022
NorthShore University HealthSystem
2021
University of Chicago
2021
Centro Tecnológico del Mar
2018
Keio University
2017
PricewaterhouseCoopers (Canada)
2012
Abstract Borderline personality disorder (BOR) is determined by environmental and genetic factors, characterized affective instability impulsivity, diagnostic symptoms also observed in manic phases of bipolar (BIP). Up to 20% BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) BOR, performed one largest BOR patient samples worldwide. The focus our analysis was (i) detect genes gene sets involved (ii) investigate overlap...
Scale discriminability is the ability of a measure to discriminate among individuals ordered along some continuum, such as depressive severity. We used nonparametric item-response model examine scale in Beck Depression Inventory (BDI) and Center for Epidemiologic Studies (CES-D) both college depressed outpatient samples. In sample, CES-D was more discriminating than BDI, but standard cutoff score 16 overestimated likely prevalence depression (45%). The may be effective BDI detecting...
Article Abstract Objective: Bipolar disorder is insufficiently controlled by medication, so several adjunctive psychosocial interventions have been tested. Few studies compared these treatments, all of which are lengthy, expensive, and difficult to disseminate. We the relative effectiveness a brief psychoeducation group intervention more comprehensive longer individual cognitive-behavioral therapy intervention, measuring longitudinal outcome in mood burden bipolar disorder. Method: This...
<h3>Importance</h3> Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, efficacy lithium varies widely, with nonresponse rate up to 30%. Biological response markers are lacking. Genetic factors thought mediate lithium, and there previously reported genetic overlap between BPAD schizophrenia (SCZ). <h3>Objectives</h3> To test whether polygenic score SCZ associated in explore potential molecular underpinnings this association. <h3>Design,...
ABSTRACT Bipolar disorder is a highly heritable psychiatric that features episodes of mania and depression. We performed the largest genome-wide association study to date, including 20,352 cases 31,358 controls European descent, with follow-up analysis 822 sentinel variants at loci P<1×10 -4 in an independent sample 9,412 137,760 controls. In combined analysis, 30 reached significant evidence for association, which 20 were novel. These contain genes encoding ion channels neurotransmitter...
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action incompletely understood, and prediction outcomes limited. In our previous multi-omics study Pharmacogenomics Bipolar Disorder (PGBD) sample combining transcriptomic genomic data, we found that focal adhesion, extracellular matrix (ECM), PI3K-Akt signaling networks were associated with response to lithium. this study, replicated results using network propagation methods in a genome-wide...
In 2019, the Harvard Museum of Comparative Zoology acquired The R. Glenn Northcutt Collection Vertebrate Neuroanatomy and Embryology, which comprises an estimated 500,000 histologic sections whole mounts prepared mounted on glass slides. Assembled by Professor between 1963 2014 to reveal microscopic anatomy nervous system related tissues, collection additionally includes valuable slide series other neuroanatomists, including John Black Johnston, Othmar Solnitzky, David Senn. Most included...
Serum growth hormone (GH) and prolactin (PRL) concentrations were measured after administration of the dopamine receptor agonist, apomorphine HC1 (0.75 mg subcutaneously), to 17 chronic schizophrenic patients, four whom had an oral dyskinesia, who withdrawn from neuroleptic therapy for periods two 15 weeks, in 21 control subjects (normal volunteers or physically healthy alcoholics not exposed neuroleptics). Six but none controls, raised baseline levels GH (greater than 6 ng/ml). After all...
Objective Promptly establishing maintenance therapy could reduce morbidity and mortality in patients with bipolar disorder. Using a machine learning approach, we sought to evaluate whether lithium responsiveness (LR) is predictable using clinical markers. Method Our data are the largest existing sample of direct interview‐based from lithium‐treated ( n = 1266, 34.7% responders), collected across seven sites, internationally. We trained random forest model classify LR—as defined by previously...
Abstract Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health that affects about 1% of population worldwide. Nevertheless, lithium not consistently effective, with only 30% patients showing favorable response to treatment. To provide personalized options patients, it essential identify prediction biomarkers such polygenic scores. In this study, we developed score (Li + PGS ) in BD. gain further insights into lithium’s possible...
Abstract The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we performed exploratory study the contributions immune-relevant genetic factors to response lithium (Li) treatment clinical presentation BP. First, assessed association large collection immune-related genes (4925) with Li response, defined by...
Objective.—To investigate the prevalence, clinical correlates, and treatment of migraine in bipolar disorder. Background.—The relationship between mood disorders has been long‐standing interest to researchers clinicians. Although a strong association demonstrated consistently for major depression, there less systematic research on links Methods.—A questionnaire (based International Headache Society criteria) was administered 108 outpatients with Information course illness also collected....
Abstract Bipolar disorder (BD) is a heritable mental illness with complex etiology. We performed genome-wide association study (GWAS) of 41,917 BD cases and 371,549 controls European ancestry, which identified 64 associated genomic loci. risk alleles were enriched in genes synaptic signaling pathways brain-expressed genes, particularly those high specificity expression neurons the prefrontal cortex hippocampus. Significant signal enrichment was found encoding targets antipsychotics, calcium...
Background Studying phenotypic and genetic characteristics of age at onset (AAO) polarity (PAO) in bipolar disorder can provide new insights into disease pathology facilitate the development screening tools. Aims To examine architecture AAO PAO their association with characteristics. Method Genome-wide studies (GWASs) polygenic score (PGS) analyses ( n = 12 977) 6773) were conducted patients from 34 cohorts a replication sample 2237). The was investigated two these cohorts. Results Earlier...