A5059604177- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Circadian rhythm and melatonin
- Adolescent and Pediatric Healthcare
- Suicide and Self-Harm Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Mental Health Treatment and Access
- Personality Disorders and Psychopathology
- Family Caregiving in Mental Illness
- Thyroid Disorders and Treatments
- Mental Health and Patient Involvement
- Psychosomatic Disorders and Their Treatments
- Health, psychology, and well-being
- Stress Responses and Cortisol
- Folate and B Vitamins Research
- Neurological disorders and treatments
- Obsessive-Compulsive Spectrum Disorders
- COVID-19 and Mental Health
- Functional Brain Connectivity Studies
Sunnybrook Health Science Centre
2015-2024
Health Sciences Centre
2015-2024
University of Toronto
2014-2024
Sunnybrook Hospital
2007-2024
Sunnybrook Research Institute
2017-2024
Ontario Brain Institute
2020
University of Manitoba
2018
Institute for Clinical Evaluative Sciences
2017-2018
The University of Melbourne
2018
Medical University of Vienna
2018
OBJECTIVES: To update clinical practice guidelines to assist primary care (PC) clinicians in the management of adolescent depression. This part updated is used address preparation, identification, assessment, and initial depression PC settings. METHODS: By using a combination evidence- consensus-based methodologies, were developed by an expert steering committee 2 phases as informed (1) current scientific evidence (published unpublished) (2) draft revision iteration among committee, which...
<h3>Importance</h3> Bright light therapy is an evidence-based treatment for seasonal depression, but there limited evidence its efficacy in nonseasonal major depressive disorder (MDD). <h3>Objective</h3> To determine the of treatment, monotherapy and combination with fluoxetine hydrochloride, compared a sham-placebo condition adults MDD. <h3>Design, Setting, Participants</h3> Randomized, double-blind, placebo- sham-controlled, 8-week trial (aged 19-60 years) MDD at least moderate severity...
To update clinical practice guidelines to assist primary care (PC) in the screening and assessment of depression. In this second part updated guidelines, we address treatment ongoing management adolescent depression PC setting.By using a combination evidence- consensus-based methodologies, were 2 phases as informed by (1) current scientific evidence (published unpublished) (2) revision iteration among steering committee, including youth families with lived experience.These are targeted for...
Objective: Light therapy and antidepressants have shown comparable efficacy in separate studies of seasonal affective disorder treatment, but few directly compared the two treatments. This study effectiveness light an antidepressant within a single trial. Method: double-blind, randomized, controlled trial was conducted four Canadian centers over three winter seasons. Patients met DSM–IV criteria for major depressive with (winter) pattern had scores ≥23 on 24-item Hamilton Depression Rating...
Death by suicide during the perinatal period has been understudied in Canada. We examined epidemiology of and health service use related to suicides pregnancy first postpartum year.In this retrospective, population-based cohort study, we linked administrative databases with coroner death records (1994-2008) for Ontario, compared sociodemographic characteristics, clinical features 30 days 1 year before between women who died perinatally, outside living women.The rate was 2.58 per 100 000 live...
Article Abstract Objective: Bipolar disorder is insufficiently controlled by medication, so several adjunctive psychosocial interventions have been tested. Few studies compared these treatments, all of which are lengthy, expensive, and difficult to disseminate. We the relative effectiveness a brief psychoeducation group intervention more comprehensive longer individual cognitive-behavioral therapy intervention, measuring longitudinal outcome in mood burden bipolar disorder. Method: This...
Exposure to media reporting on suicide can lead contagion and, in some circumstances, may also help-seeking behaviour. There is limited evidence for which specific characteristics of reports mediate these phenomena.This observational study examined associations between putatively harmful and protective elements about 13 major publications the Toronto market subsequent deaths (2011-2014). We used multivariable logistic regression determine whether article were associated with increases or...
Canadian youth (aged 16-24) have the highest rates of mental health and addiction concerns across all age groups most unmet care needs. There are many structural barriers that contribute to needs including lack available appropriate services, high costs, long wait times, fragmented siloed smooth transition between child adult stigma, racism, discrimination, as well culturally treatments. Levesque et al. (2013) developed a framework better understand access this conceptualizes accessibility...
Objective: This study reports on the lifetime prevalence and illness characteristics of bipolar disorder (BD) in a large, representative sample Canadians. Method: Data were obtained from Canadian Community Health Survey: Mental Well-Being. representative, cross-sectional survey, conducted by Statistics Canada 2002, examines mental health Canadians aged 15 years over. The national response rate was 77%. We determined BD, correlates diagnosis, characteristics. Results: weighted BD 2.2% (95%...
The authors investigated the efficacy and safety of fluoxetine in treatment winter seasonal affective disorder.Sixty-eight outpatients who met DSM-III-R criteria for recurrent major depressive episodes, (winter) pattern, were randomly assigned to 5 weeks with fluoxetine, 20 mg/day (N = 36), or placebo 32). outcome measures included 29-item modified Hamilton Depression Rating Scale, administered by experienced clinicians, self-rated Beck Inventory; adverse events data also recorded. Clinical...
Annual suicide deaths outnumber the total from homicide and war combined. Suicide is a complex behavioral endpoint, simple cause-and-effect model seems highly unlikely, but relationships with weather could yield important insight into biopsychosocial mechanisms involved in deaths. This study has been designed to test for relationship between air temperature frequency that consistent enough offer some predictive abilities. Weekly death totals anomalies Toronto, Ontario, Canada (1986–2009)...
The authors used the anxiety summary score described by Clayton and associates to assess anxious nonanxious subtypes of depression in a group 134 outpatients with major depression. Patients were only slightly less likely respond their first tricyclic antidepressant than patients When functional severity or symptom was controlled for, this differential treatment response did not hold.