A5032572246- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Pharmaceutical studies and practices
- Psychiatric care and mental health services
- Psychosomatic Disorders and Their Treatments
- Sleep and related disorders
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Attention Deficit Hyperactivity Disorder
- Suicide and Self-Harm Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Electrolyte and hormonal disorders
- Pharmacovigilance and Adverse Drug Reactions
- Psychoanalysis and Social Critique
- Coordination Chemistry and Organometallics
- Restless Legs Syndrome Research
- Child and Adolescent Psychosocial and Emotional Development
- Diet and metabolism studies
- Neurotransmitter Receptor Influence on Behavior
- Pharmaceutical Practices and Patient Outcomes
- Complementary and Alternative Medicine Studies
Medizinische Hochschule Brandenburg Theodor Fontane
2019-2024
Charité - Universitätsmedizin Berlin
2011-2024
German Medical Association
2007-2023
Arzneimittelkommission der deutschen Ärzteschaft
2010-2023
TU Dresden
2022
Ludwig-Maximilians-Universität München
1987-2019
LMU Klinikum
2019
Berlin Heart (Germany)
2012-2019
Freie Universität Berlin
2001-2018
University of Würzburg
2001-2012
Therapeutic Drug Monitoring (TDM) enables the clinician to adjust dosage of drugs according characteristics individual patient. The interdisciplinary TDM group Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) has worked out consensus guidelines assist psychiatrists and laboratories involved in psychotropic drug analysis optimise use drugs. Five research-based levels recommendation were defined with regard routine monitoring plasma concentrations for dose...
The management and treatment of patients with suicidal behavior is one the most challenging tasks for health-care professionals. Patients affective disorders are at high risk behavior, therefore, should be a target prevention. Numerous international studies lithium use have documented anti-suicidal effects since 1970s. Despite unambiguous evidence lithium's recommendations in national guidelines its acute maintenance therapy disorders, still underrepresented. following article provides...
Recent findings have indicated that lithium treatment markedly reduces suicide risk in major affective disorders. To compare the effect of with carbamazepine and amitriptyline, suicidal behavior was analyzed during randomized prospective long-term MAP study (N = 378; duration 2.5 years). Of nine suicides five attempted suicides, none took place treatment. The support view has a specific antisuicidal over above its prophylactic benefit.
In a randomized, prospective, multicenter study with an observation period of 2.5 years, the differential prophylactic efficacy lithium versus carbamazepine was compared in 171 patients fulfilling DSM-IV criteria for bipolar disorder. Serum drug levels were 0.6 +/- 0.1 mmol/L and 6.1 1.3 [micro sign]g/mL carbamazepine. Patients subdivided into classical subgroup (bipolar I without mood-incongruent delusions comorbidity, N = 67) nonclassical including all other (N 104). Classical had lower...
Objectives The genetically polymorphic enzyme cytochrome P450 (CYP) 2D6 contributes to the biotransformation of antipsychotic drug haloperidol. impact polymorphism on haloperidol pharmacokinetics, adverse events, and efficacy was prospectively evaluated under naturalistic conditions in 172 unselected psychiatric inpatients with acute psychotic symptoms. Methods Serum trough levels reduced patients receiving clinically adjusted doses were analyzed days 3, 14, 28 after hospital admission....
Objective: Studies on the time sense of depressed patients have revealed inconsistent results. Manic been almost neglected. Method: Patients with a major depressive episode ( n = 32), or manic 30) (both Diagnostic and Statistical Manual Mental Disorders‐IV, Mini‐International Neuropsychiatric Interview‐confirmed), 31 healthy controls were included. The subjective experience was assessed by visual analog scale (VAS), objectively measurable judgment abilities Chronotest, computer program...
Evidence based on controlled studies is still limited for treatment strategies that prevent recurrence of suicide attempts. Findings from observational as well meta-analytic strongly suggest lithium may have suicide-protective properties.Patients with a recent attempt in the context an affective spectrum disorder (n = 167) were treated either or placebo during 12-month period.Survival analysis showed no significant difference suicidal acts between and placebo-treated individuals (adjusted...
Concerns about potential adverse effects of long-term exposure to lithium as a mood-stabilizing treatment notably include altered renal function. However, the incidence severe dysfunction; rate decline over time; dose, serum concentration, and duration treatment; relative vs. aging; contributions sex other factors all remain unclear.Accordingly, we acquired data from 12 collaborating international sites 312 bipolar disorder patients (6142 person-years, 2669 assays) treated with carbonate for...
To compare the efficacy of sodium valproate administered as adjunct to neuroleptic medication for patients with acute mania neuroleptics alone, authors conducted a 21-day, randomized, double-blind, parallel-group, placebo-controlled trial. The study design closely reflected clinical psychiatric setting in Europe where commonly receive medication. In this trial, 136 hospitalized met ICD-10 criteria manic episodes; these received fixed dose 20 mg/kg body weight (Orfiril, Desitin Arzneimittel...
OBJECTIVE: Use of lithium to augment antidepressant medication has been shown be beneficial in the acute treatment depression. The authors examined efficacy augmentation continuation unipolar major depressive disorder. METHOD: Thirty patients with a refractory episode who had responded during an open 6-week study participated randomized, parallel-group, double-blind, placebo-controlled trial treatment. After 2–4-week stabilization period following remission, were randomly assigned receive...
Clinical research centers in Aarhus, Berlin, Hamilton and Vienna collected mortality data for 827 manic‐depressive schizoaffective patients given lithium treatment more than 6 months. The average duration of the was 81 months total time on 5600 patient‐years. For each patient, risk calculated by entering appropriate national life tables general population. number observed deaths 44; expected 49.7. standardized ratio, 0.89, did not differ significantly from 1.0. is 2–3 times that Our show...
Recent investigations have indicated that adequate lithium treatment lowers the suicide mortality associated with affective illness. One important question is whether mechanism by which prophylaxis may be effective in prolonging survival can explained exclusively terms of successful protection against recurrence depressive episodes, or one should consider an independent anti-suicidal factor.We investigated a group high-risk patients recurrent disorders (n = 167) who had committed more...
Expressed emotion (EE) in key relatives of 21 patients with bipolar affective or schizoaffective psychoses was assessed by the CFI. All had been on prophylactic lithium for at least three years and were without psychotic symptoms interview. The relationship between relatives' EE status patients' course illness studied both retrospectively prospectively. Two critical remarks designated high EE. not related to number hospital admissions severity length recurrences if entire period treatment is...
Objective Promptly establishing maintenance therapy could reduce morbidity and mortality in patients with bipolar disorder. Using a machine learning approach, we sought to evaluate whether lithium responsiveness (LR) is predictable using clinical markers. Method Our data are the largest existing sample of direct interview‐based from lithium‐treated ( n = 1266, 34.7% responders), collected across seven sites, internationally. We trained random forest model classify LR—as defined by previously...
Interpersonal touch represents the primal sensory experience between humans, fostering social bonding from cradle to death bed. In recent decades “affective touch” has been intensely studied, stimulated by discovery of a population mechanosensitive unmyelinated C-tactile afferents in mammalian skin. A lack childhood is associated with negative consequences for psychosocial and physical health benefits professional techniques prevention treatment various diseases have shown over again...