A5088333756- Birth, Development, and Health
- Pharmacological Effects and Toxicity Studies
- Neonatal Respiratory Health Research
- Schizophrenia research and treatment
- Pregnancy and Medication Impact
- Epilepsy research and treatment
- Genetic Associations and Epidemiology
- Health disparities and outcomes
- Adolescent and Pediatric Healthcare
- Pregnancy and preeclampsia studies
- Maternal Mental Health During Pregnancy and Postpartum
- Fluoride Effects and Removal
- Health, Environment, Cognitive Aging
- Folate and B Vitamins Research
- Child and Adolescent Psychosocial and Emotional Development
- Attention Deficit Hyperactivity Disorder
- Parkinson's Disease Mechanisms and Treatments
- Genomic variations and chromosomal abnormalities
- Child Abuse and Trauma
- Congenital heart defects research
- Child and Adolescent Health
- Breastfeeding Practices and Influences
- Congenital Heart Disease Studies
- Genetics and Neurodevelopmental Disorders
- Cytomegalovirus and herpesvirus research
Aarhus University
2015-2025
Lundbeck Foundation
2015-2022
Karolinska Institutet
2020
The University of Queensland
2020
University Medical Center Utrecht
2020
Royal Brisbane and Women's Hospital
2020
Copenhagen University Hospital
2016
Knowledge about the epidemiology of mental disorders in children and adolescents is essential for research planning health services. Surveys can provide prevalence rates, whereas population-based registers are instrumental to obtain precise estimates incidence rates risks.To estimate age- sex-specific risks being diagnosed with any disorder during childhood adolescence.This cohort study included all individuals born Denmark from January 1, 1995, through December 31, 2016 (1.3 million),...
Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior. This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify who a diagnosis (N = 2591), attempted or committed suicide 655), had traffic accidents 2724). For all cases, controls were frequency matched by age sex, resulting in 11,546 participants. Plasma samples analyzed for immunoglobulin G (IgG) antibodies against...
Importance Concerns exist about teratogenic and long-term neurodevelopmental outcomes of paternal use valproate during spermatogenesis. Objective To evaluate the association between spermatogenesis offspring risk congenital malformations disorders. Design, Setting, Participants This nationwide cohort study included 1 235 353 singletons born in Denmark January 1, 1997, December 31, 2017, identified Medical Birth Register; 1336 children had fathers who filled prescriptions for Congenital were...
Microdeletions and duplications have been described at the 22q11.2 locus. However, little is known about clinical epidemiologic consequences population level.To identify indicators of deletions or locus estimate incidence rate ratios (IRRs) absolute risk for psychiatric disorders in clinically identified individuals with deletion duplication.A Danish nationwide register study including all recorded Cytogenetic Central Register a duplication was performed. A total 3 768 943 born Denmark from...
Combining information on polygenic risk scores (PRSs) with other known factors could potentially improve the identification of depression in general population. However, to our knowledge, no study has estimated association PRS absolute depression, and few have examined combinations important factors, including parental history psychiatric disorders socioeconomic status (SES), risk.To assess individual joint associations PRS, history, SES relative early-onset depression.This case-cohort...
There is limited evidence that nitrate, a common contaminant in drinking water, increases the risk of childhood cancers. Our objective was to examine this association Denmark.We conducted nationwide case-control study based on all singletons liveborn Danish-born parents from 1991 2015 (N = 1,219,140) included 596 leukemias, 180 lymphomas, and 310 central nervous system cancers (CNC) who were ≤15 years age at diagnosis identified Danish Cancer Registry. Approximately 100 controls randomly...
A few studies have reported an increased risk of birth defects (BD) with maternal exposure to nitrate in drinking water. We examined this association a large cohort study well-characterized exposure.Danish singletons liveborn Danish-born parents from 1991-2013 were identified using civil and patient registries (n=1,018,914). Exposure was estimated spatial model based on national data linked individual addresses. Odds ratios (OR) 95% confidence intervals (95% CI) logistic regression.In total,...
Traumatic stress disorders are prevalent in patients with schizophrenia and bipolar disorder. However, there is a lack of prospective longitudinal studies investigating the risk severe mental illness for people diagnosed traumatic disorders. We aimed to assess if acute reaction (ASR) or post-traumatic disorder (PTSD) at increased spectrum disorder.We performed cohort study covering entire Danish population including information on inpatient outpatient hospitals over 2 decades. Predictors...
Background Studies have indicated that the association of urbanicity at birth and during upbringing with schizophrenia may be driven by familial factors such as genetic liability. We used a population-based nested case–control study to assess whether polygenic risk score (PRS) for was associated age 15, PRS parental history mental disorder together explained between schizophrenia. Methods Data were drawn from Danish population registries. Cases born since 1981 diagnosed 1994 2009 matched...
To investigate the genetic contribution to amyotrophic lateral sclerosis (ALS) and phenotypic associations between ALS psychiatric cardiovascular disorders (CVD) we used national registry data from Denmark linked first-degree relatives estimate heritability cross-trait parameters.ALS cases 100 sex birth-matched controls per case Danish Civil Registration System were their records in National Patient Registry. Cases compared for (1) risk of relatives, heritability, (2) comorbidity with CVD,...
BACKGROUND: High levels of nitrate (NO - 3 ) in drinking water cause methemoglobinemia infants; however, few studies have examined the potential effects low-level exposure on fetal growth, and results been inconsistent.OBJECTIVES: We sought to assess association between maternal during pregnancy offspring size at birth a nationwide study full-term (≥37 wk gestation) live-born singletons.METHODS: estimated for 898,206 births Denmark 1991-2011 by linkage individual home address(es) with data...
The US Food and Drug Administration recently issued a warning against the use of antiseizure medication lamotrigine in people at risk cardiac rhythm conduction abnormalities. This study assessed morbidity mortality new users lamotrigine.In Danish population-based cohort study, we followed members aged ≥15 years for first 2 after they initiated therapy. main outcomes were disorders without pre-existing all-cause with morbidity. Cox proportional hazards models provided hazard ratios (HRs)...
Background We quantify the loss of working years for people with epilepsy compared general population and consider variation by aetiology, psychiatric comorbidity, sex age. Methods This population-based cohort study included all individuals aged 18–65 living in Denmark from 1995 to 2018. Using nationwide registers since 1977, we identified obtained information on main source income or employment each year during follow-up 2020. The outcome was number lost same age, capturing both life due...
Reproduction is lower in male individuals compared with female epilepsy. The reason unknown. We studied sex-specific reproduction epilepsy and the role of subtype psychiatric comorbidity. conducted a population-based register study Denmark, using data from January 1, 1982, to December 31, 2021. Cox proportional hazard models were used estimate adjusted ratios (aHRs) 95% CIs for chance having ≥1 child. followed all persons 15 years age until birth live-born offspring, 45 age, emigration,...
No AccessJournal of UrologyPediatric Article17 Mar 2025Childhood functional urinary incontinence and school performance: a nationwide matched cohort study Britt Borg, MD, PhD Betina B. Trabjerg, Julie Werenberg Dreier, Søren Rittig, MD DMSc Anders Breinbjerg, Jakob Christensen, Kristian Juul, Per Hove Thomsen, andMD Konstantinos KamperisMD BorgBritt Borg Corresponding author – ([email protected]) - +4522740973 https://orcid.org/0009-0002-0166-9999 , TrabjergBetina Trabjerg National Centre...
Abstract The objective of the present study was to investigate whether polygenic liability for attention-deficit/hyperactivity disorder (ADHD) and psychosocial environment impact risk ADHD in interaction or independently each other. We conducted a register- biobank-based cohort 13,725 individuals with 20,147 randomly drawn population-based controls. These 33,872 members were genotyped on Infinium PsychChip v1.0 array (Illumina). Subsequently, we calculated score (PRS) extracted register data...
<h3>Importance</h3> Concerns exist about long-term neurodevelopmental consequences of prenatal exposure to antidepressants. <h3>Objective</h3> To evaluate whether maternal prescription fill for antidepressants in pregnancy was associated with performance standardized tests among Danish schoolchildren. <h3>Design, Setting, and Participants</h3> Population-based retrospective cohort study children born Denmark between January 1, 1997, December 31, 2009, attending public primary lower secondary...
Prenatal nitrate exposure from household tap water has been associated with increased risk of fetal growth restriction, preterm birth, birth defects, and childhood cancer. We aim to examine the association between maternal consumption drinking-water during pregnancy small-for-gestational-age (SGA) in a nationwide study Danish-born children, as only one prior examined this association.We linked individual-level estimates registry data all live singleton Danish births 1991-2015 parents where...
Abstract Objective Prenatal exposure to the antiseizure medication (ASM) valproate is associated with an increased risk of congenital malformations, but warnings against use in pregnancy were not issued until 2009. The objective was study how early administrative health registers could have identified teratogenic valproate. Methods This a population‐based cohort individual‐linked data from Danish care and socioeconomic including children born Denmark between January 1, 1997 December 31,...
Background and purpose Amyotrophic lateral sclerosis (ALS) risk increases with age, a linear log‐incidence log‐age relationship is interpreted to suggest that five six factors are involved in disease onset. The remain unidentified, except fewer steps predicted for those carrying known ALS‐causing mutation. Methods Men psychiatric disorder or cardiovascular (CVD) diagnosis have an increased relative of ALS. Using the Danish population registries ALS years 1980 2017, we tested whether these...
Background Depression is known to run in families, but the effects of parental history other psychiatric diagnoses on depression rates are less well studied. Few studies have examined impact psychopathology older age groups. Method We established a population-based cohort including all individuals born Denmark after 1954 and alive their 10th birthday ( N = 29 76 264). Exposure variables were maternal paternal schizophrenia, bipolar disorder, depression, anxiety or ‘other’ diagnoses....
Background: Evidence is emerging that preterm birth (PTB, before 37 completed weeks of gestation), a risk factor for neonatal mortality and future morbidity, may be induced by maternal nitrate ( ) exposure from drinking water. The objective this study to assess the association between PTB in nationwide liveborn singletons. Methods: We estimated household tap water 1,055,584 births Denmark Danish-born parents during 1991–2015 linkage individual home address(es) with concentrations national...