A5003685616- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and preeclampsia studies
- Neonatal and fetal brain pathology
- Adolescent and Pediatric Healthcare
- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Infant Development and Preterm Care
- Thermal Regulation in Medicine
- Neonatal Health and Biochemistry
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Electrolyte and hormonal disorders
- Traumatic Brain Injury Research
- Bipolar Disorder and Treatment
- Attention Deficit Hyperactivity Disorder
- Genetic Associations and Epidemiology
- Advanced Causal Inference Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Schizophrenia research and treatment
- Folate and B Vitamins Research
Aarhus University
2017-2025
University of Bergen
2022-2024
Aarhus University Hospital
2019-2022
University of Copenhagen
2017-2022
Haukeland University Hospital
2022
Karolinska University Hospital
2022
National Epilepsy Center
2022
Finnish Institute for Health and Welfare
2022
Lundbeck Foundation
2022
Stanford University
2022
<h3>Importance</h3> Women with epilepsy frequently need antiseizure medication (ASM) to prevent seizures in pregnancy. Risk of neurodevelopmental disorders after prenatal exposure AMSs is uncertain. <h3>Objective</h3> To determine whether children exposed prenatally ASMs monotherapy and duotherapy have increased risk disorders. <h3>Design, Setting, Participants</h3> The Nordic register-based study antiepileptic drugs pregnancy (SCAN-AED) a population-based cohort using health register social...
Women with epilepsy are recommended high doses of folic acid before and during pregnancy owing to risk congenital anomalies associated antiseizure medications. Whether prenatal exposure high-dose is increases in the childhood cancer unknown.To assess whether supplementation mothers cancer.Observational cohort study conducted nationwide registers Denmark, Norway, Sweden from 1997 2017. Analyses were performed January 10, 2022, 31, 2022. Mother-child pairs identified medical birth linked...
Prenatal antiseizure medication (ASM) exposure has been associated with adverse early neurodevelopment, but associations a wider range of psychiatric end points have not studied.
Importance Concerns exist about teratogenic and long-term neurodevelopmental outcomes of paternal use valproate during spermatogenesis. Objective To evaluate the association between spermatogenesis offspring risk congenital malformations disorders. Design, Setting, Participants This nationwide cohort study included 1 235 353 singletons born in Denmark January 1, 1997, December 31, 2017, identified Medical Birth Register; 1336 children had fathers who filled prescriptions for Congenital were...
<h3>Importance</h3> Valproate is an antiepileptic drug (AED) used in the treatment of epilepsy and many other neurological psychiatric disorders. Its use pregnancy associated with increased risks congenital malformations adverse neurodevelopment offspring may be risk attention-deficit/hyperactivity disorder (ADHD). <h3>Objective</h3> To determine whether prenatal exposure to valproate AEDs ADHD offspring. <h3>Design, Setting, Participants</h3> This was a population-based cohort study all...
The short- and long-term consequences of restricted fetal growth cause considerable concern, how prenatal exposure to different antiseizure medications (ASMs) affects remains uncertain. This was a population-based cohort study liveborn singleton children born in Denmark, Finland, Iceland, Norway, Sweden from 1996 2017. Prenatal defined as maternal filling prescriptions for ASM during pregnancy registered national prescription registries primary outcomes were adjusted odds ratios (aORs)...
Background Fever and infections are common events during pregnancy, have been shown to be associated with neurodevelopmental impairment in the offspring. The evidence relation attention deficit/hyperactivity disorder ( ADHD ) is, however, nonexistent for fever limited infections. aim of this study was therefore investigate impact these exposures on occurrence offspring, considering gestational timing as well intensity exposure. Methods conducted within Danish National Birth Cohort, using...
Abstract Febrile seizures represent the most common type of pathological brain activity in young children and are influenced by genetic, environmental developmental factors. In a minority cases, febrile precede later development epilepsy. We conducted genome-wide association study 7635 cases 83 966 controls identifying replicating seven new loci, all with P &lt; 5 × 10−10. Variants at two loci were functionally related to altered expression fever response genes PTGER3 IL10, four other...
Epilepsy and depression share a bidirectional relationship; however, its magnitude long-term temporal association remain to be elucidated. This study investigates the between epilepsy depression, comparing with risks of 2 disorders after another chronic medical illness (asthma).In nationwide register-based matched cohort study, we identified all individuals who received first diagnosis epilepsy, asthma from January 1, 1980, December 31, 2016. We used Cox regression model estimate risk vice...
In a variety of animal species, hyperthermia in pregnancy has been recognized as teratogenic. Hyperthermia interferes with protein synthesis via heat-shock proteins, which can entail membrane disruption, cell death, vascular and placental infarction. This induce severe fetal malformations or death. Fever during pregnancy, especially embryogenesis, also associated congenital human offspring. The purpose this large cohort study clinically pregnancies was to investigate whether fever first...
Febrile seizures occur in 2% to 5% of children between the ages 3 months and 5 years. Many affected experience recurrent febrile seizures. However, little is known about association subsequent prognosis.To estimate risk whether there an over long-term follow-up epilepsy, psychiatric disorders, death a large, nationwide, population-based cohort Denmark.This study evaluated data from all singleton born Denmark January 1, 1977, December 31, 2011, who were identified through Danish Civil...
There is concern about neurodevelopmental outcomes associated with prenatal exposure to valproate and other antiepileptic drugs (AEDs) among children of mothers or without epilepsy.To study the risk intellectual disability delayed development in childhood milestones women who used AEDs during pregnancy.This population-based cohort analyzed information on use from Danish National Prescription Registry register diagnoses Psychiatric Central Research Register Patient Registry. The included all...
This study estimated epilepsy prevalence, psychiatric co-morbidity and annual costs associated with epilepsy.We used Danish national health registers to identify persons diagnosed disorders, using antiseizure medication drugs for disorders. We calculated the prevalence of co-morbid disorders in Denmark on December 31, 2016, information based combinations hospital contacts use psychoactive medication. Further, direct indirect were individual-level data from a range socioeconomic...
Genome-wide association studies (GWASs) have revolutionized human genetics, allowing researchers to identify thousands of disease-related genes and possible drug targets. However, case-control status does not account for the fact that all controls may lived through their period risk disorder interest. This can be quantified by examining age-of-onset distribution age or onset cases. The also depend on information such as sex birth year. In addition, family history is routinely included in...
Abstract Mortality rates are two to three times higher in people with epilepsy than the general population. This study aimed quantify how this increased mortality translates into reduced life expectancy and identify underlying causes of deaths, thereby offering suggestions for reduce associated epilepsy. In population-based cohort study, we included all individuals aged 0–94 years who were living Denmark between 2000 2015. Using nationwide registers, identified diagnosed estimated excess...
The US Food and Drug Administration recently issued a warning against the use of antiseizure medication lamotrigine in people at risk cardiac rhythm conduction abnormalities. This study assessed morbidity mortality new users lamotrigine.In Danish population-based cohort study, we followed members aged ≥15 years for first 2 after they initiated therapy. main outcomes were disorders without pre-existing all-cause with morbidity. Cox proportional hazards models provided hazard ratios (HRs)...
Importance Use of valproate and certain other antiseizure medications (ASMs) in pregnancy is associated with abnormal fetal brain development potential long-term implications for the child. Objective To examine whether use ASMs among mothers epilepsy risk their children. Design, Setting, Participants This prospective, population-based register cohort study included singletons born to Denmark, Finland, Iceland, Norway, Sweden from January 1, 1996, December 31, 2017. Data analysis was...
Mental disorders are associated with elevated mortality rates and reduced life expectancy. However, it is unclear whether these associations differ by socioeconomic position (SEP). The aim of this study was to explore comprehensively the role individual‐level SEP in between specific types mental (due all causes, natural or external causes), presenting both relative absolute measures. This a cohort including residents Denmark on January 1, 2000, following them up until December 31, 2020....
Background We quantify the loss of working years for people with epilepsy compared general population and consider variation by aetiology, psychiatric comorbidity, sex age. Methods This population-based cohort study included all individuals aged 18–65 living in Denmark from 1995 to 2018. Using nationwide registers since 1977, we identified obtained information on main source income or employment each year during follow-up 2020. The outcome was number lost same age, capturing both life due...
Reproduction is lower in male individuals compared with female epilepsy. The reason unknown. We studied sex-specific reproduction epilepsy and the role of subtype psychiatric comorbidity. conducted a population-based register study Denmark, using data from January 1, 1982, to December 31, 2021. Cox proportional hazard models were used estimate adjusted ratios (aHRs) 95% CIs for chance having ≥1 child. followed all persons 15 years age until birth live-born offspring, 45 age, emigration,...
No AccessJournal of UrologyPediatric Article17 Mar 2025Childhood functional urinary incontinence and school performance: a nationwide matched cohort study Britt Borg, MD, PhD Betina B. Trabjerg, Julie Werenberg Dreier, Søren Rittig, MD DMSc Anders Breinbjerg, Jakob Christensen, Kristian Juul, Per Hove Thomsen, andMD Konstantinos KamperisMD BorgBritt Borg Corresponding author – ([email protected]) - +4522740973 https://orcid.org/0009-0002-0166-9999 , TrabjergBetina Trabjerg National Centre...
Women with epilepsy treated antiseizure medication (ASM) have increased risk of pregnancy complications including preterm birth, fetal growth restriction, and preeclampsia. We aimed to investigate whether folic acid supplementation is associated these in women using ASM.Singleton pregnancies the prospective Norwegian Mother Child Cohort Study (MoBa) (1999-2008) were included. Information on maternal epilepsy, ASM, supplementation, outcomes was obtained from MoBa questionnaires Medical Birth...