<h3>Importance</h3> Women with epilepsy frequently need antiseizure medication (ASM) to prevent seizures in pregnancy. Risk of neurodevelopmental disorders after prenatal exposure AMSs is uncertain. <h3>Objective</h3> To determine whether children exposed prenatally ASMs monotherapy and duotherapy have increased risk disorders. <h3>Design, Setting, Participants</h3> The Nordic register-based study antiepileptic drugs pregnancy (SCAN-AED) a population-based cohort using health register social...

Women with epilepsy are recommended high doses of folic acid before and during pregnancy owing to risk congenital anomalies associated antiseizure medications. Whether prenatal exposure high-dose is increases in the childhood cancer unknown.To assess whether supplementation mothers cancer.Observational cohort study conducted nationwide registers Denmark, Norway, Sweden from 1997 2017. Analyses were performed January 10, 2022, 31, 2022. Mother-child pairs identified medical birth linked...

Prenatal antiseizure medication (ASM) exposure has been associated with adverse early neurodevelopment, but associations a wider range of psychiatric end points have not studied.

<h3>Importance</h3> Valproate is an antiepileptic drug (AED) used in the treatment of epilepsy and many other neurological psychiatric disorders. Its use pregnancy associated with increased risks congenital malformations adverse neurodevelopment offspring may be risk attention-deficit/hyperactivity disorder (ADHD). <h3>Objective</h3> To determine whether prenatal exposure to valproate AEDs ADHD offspring. <h3>Design, Setting, Participants</h3> This was a population-based cohort study all...

The short- and long-term consequences of restricted fetal growth cause considerable concern, how prenatal exposure to different antiseizure medications (ASMs) affects remains uncertain. This was a population-based cohort study liveborn singleton children born in Denmark, Finland, Iceland, Norway, Sweden from 1996 2017. Prenatal defined as maternal filling prescriptions for ASM during pregnancy registered national prescription registries primary outcomes were adjusted odds ratios (aORs)...

Valproate sodium is used for the treatment of epilepsy and other neuropsychiatric disorders in women childbearing potential. However, there are concerns about impaired cognitive development children who have been exposed to valproate during pregnancy.To estimate association between long-term school performance prenatal exposure a number antiepileptic drugs (AEDs).In prospective, population-based cohort study conducted from August 1, 2015, May 31, 2017, data were provided by Statistics...

OBJECTIVE. Eclampsia has been found to be a strong risk factor for epilepsy in the offspring, but it is unclear whether also applies preceding condition, preeclampsia. METHODS. We conducted population-based cohort study of 1537860 singletons born Denmark (1978–2004). Information on preeclampsia (mild, severe, and unspecified), eclampsia, was obtained from Danish National Hospital Register. gestational age, birth weight, Apgar score Medical Birth Registry. used Cox proportional hazard models...

Febrile seizures occur in 2% to 5% of children between the ages 3 months and 5 years. Many affected experience recurrent febrile seizures. However, little is known about association subsequent prognosis.To estimate risk whether there an over long-term follow-up epilepsy, psychiatric disorders, death a large, nationwide, population-based cohort Denmark.This study evaluated data from all singleton born Denmark January 1, 1977, December 31, 2011, who were identified through Danish Civil...

There is concern about neurodevelopmental outcomes associated with prenatal exposure to valproate and other antiepileptic drugs (AEDs) among children of mothers or without epilepsy.To study the risk intellectual disability delayed development in childhood milestones women who used AEDs during pregnancy.This population-based cohort analyzed information on use from Danish National Prescription Registry register diagnoses Psychiatric Central Research Register Patient Registry. The included all...

This study estimated epilepsy prevalence, psychiatric co-morbidity and annual costs associated with epilepsy.We used Danish national health registers to identify persons diagnosed disorders, using antiseizure medication drugs for disorders. We calculated the prevalence of co-morbid disorders in Denmark on December 31, 2016, information based combinations hospital contacts use psychoactive medication. Further, direct indirect were individual-level data from a range socioeconomic...

Importance Use of valproate and certain other antiseizure medications (ASMs) in pregnancy is associated with abnormal fetal brain development potential long-term implications for the child. Objective To examine whether use ASMs among mothers epilepsy risk their children. Design, Setting, Participants This prospective, population-based register cohort study included singletons born to Denmark, Finland, Iceland, Norway, Sweden from January 1, 1996, December 31, 2017. Data analysis was...

Background: Low Apgar scores are associated with high risk of neonatal death, cerebral palsy, and mental retardation, but the association between long-term epilepsy remains unresolved. Methods: We carried out a population-based cohort study 1,538,732 live newborns in Denmark 1 January 1978 31 December 2002 by using national registers. The at or 5 minutes were recorded midwives following standardized procedures. obtained information on linking National Hospital Register. Cohort members...

The authors evaluated the association between gestational age, birth weight, intrauterine growth, and epilepsy in a population-based cohort of 1.4 million singletons born Denmark (1979–2002). A total 14,334 inpatients (1979–2002) outpatients (1995–2002) with were registered Danish National Hospital Register. Children who potentially growth restricted identified through two methods: 1) sex-, birth-order-, gestational-age-specific z score weight; 2) deviation from expected weight estimated...

OBJECTIVE. We estimated the association between prenatal exposure to maternal infections and subsequent risk for epilepsy in childhood. METHODS. included 90619 singletons who were born September 1997 June 2003 Danish National Birth Cohort followed them up December 2005. Information on during pregnancy (cystitis, pyelonephritis, diarrhea, coughs lasting &amp;gt;1 week, vaginal yeast infection, genital herpes, venereal warts, herpes labialis) was prospectively reported by mothers 2...

Women with epilepsy treated antiseizure medication (ASM) have increased risk of pregnancy complications including preterm birth, fetal growth restriction, and preeclampsia. We aimed to investigate whether folic acid supplementation is associated these in women using ASM.Singleton pregnancies the prospective Norwegian Mother Child Cohort Study (MoBa) (1999-2008) were included. Information on maternal epilepsy, ASM, supplementation, outcomes was obtained from MoBa questionnaires Medical Birth...

<h3>Importance</h3> Concerns exist about long-term neurodevelopmental consequences of prenatal exposure to antidepressants. <h3>Objective</h3> To evaluate whether maternal prescription fill for antidepressants in pregnancy was associated with performance standardized tests among Danish schoolchildren. <h3>Design, Setting, and Participants</h3> Population-based retrospective cohort study children born Denmark between January 1, 1997, December 31, 2009, attending public primary lower secondary...

Seizures are often found in children with fetal alcohol syndrome, but it is not known whether binge drinking during pregnancy by nonalcoholic women associated an increased risk of seizure disorders children. The authors conducted a population-based cohort study 80,526 liveborn singletons the Danish National Birth Cohort (1996-2002). Information on maternal (intake > or = 5 drinks single occasion) was collected 2 computer-assisted telephone interviews pregnancy. Children were followed for up...

Background and Aim Maternal infections during pregnancy have been associated with several neurological disorders in the offspring. However, given lack of specificity for both exposures outcomes, other factors related to infection such as impaired maternal immune function may be involved causal pathway. If plays a role, we would expect before these outcomes. Methods/Principal Findings The study population included all first-born singletons Denmark between January 1 1982 December 31 2004. We...

Abstract Objective Prenatal exposure to the antiseizure medication (ASM) valproate is associated with an increased risk of congenital malformations, but warnings against use in pregnancy were not issued until 2009. The objective was study how early administrative health registers could have identified teratogenic valproate. Methods This a population‐based cohort individual‐linked data from Danish care and socioeconomic including children born Denmark between January 1, 1997 December 31,...

Abstract Objective This study was undertaken to characterize the use of higher doses folic acid (≥1 mg daily) in relation pregnancy Denmark, Norway, and Sweden women with epilepsy treated antiseizure medication (ASM). Methods In this observational study, we used data from national medical birth, patient, prescription registers retrospectively identify pregnancies ASM 2006 2017. The proportion dose supplementation among receiving for calculated according country origin, time period, type ASM....

Background To evaluate the impact of surgically induced first-trimester abortion on risk miscarriage in a subsequent pregnancy.

The aim of this study was to assess the correlation sperm morphology with intrauterine insemination (IUI) outcome in patients normal concentration and motility. About 412 couples who underwent 908 IUI cycles were involved present study. A total 110 clinical pregnancies achieved a pregnancy rate 12.11% per cycle. rates cycle 7.60%, 12.67%, 13.62% 13.13% <5%, 5-9%, 10-14% >14% forms, respectively. lowest (7.60%) obtained group forms below 5%. However, not significantly different from other...