A5061766242- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Gestational Diabetes Research and Management
- Reproductive Health and Technologies
- Neonatal Respiratory Health Research
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Global Maternal and Child Health
- Ectopic Pregnancy Diagnosis and Management
- Demographic Trends and Gender Preferences
- Preterm Birth and Chorioamnionitis
- Family Dynamics and Relationships
- Reproductive Health and Contraception
- Maternal and Perinatal Health Interventions
- Ovarian function and disorders
- Health disparities and outcomes
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy-related medical research
- Cardiovascular Conditions and Treatments
- Congenital Heart Disease Studies
- Pregnancy and Medication Impact
- Hemispheric Asymmetry in Neuroscience
- Cancer Risks and Factors
- Folate and B Vitamins Research
Université de Montpellier
2025
Institut de Recherche pour le Développement
2025
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2025
Centre National de la Recherche Scientifique
2025
McGill University
2015-2024
McGill University Health Centre
2014-2023
Montreal Children's Hospital
2023
Children's Hospital of Eastern Ontario
2019-2022
Queen's University
2022
Kingston Health Sciences Centre
2022
<h3>Abstract</h3> <b>Objectives</b> To examine whether infertile couples (with a time to pregnancy of > 12 months), who conceive naturally or after treatment, give birth children with an increased prevalence congenital malformations. <b>Design</b> Longitudinal study. <b>Setting</b> Danish national cohort. <b>Participants</b> Three groups liveborn and their mothers: 50 897 singletons 1366 twins born fertile (time ≤ 5764 100 conceived 4588 1690 infertility treatment. <b>Main outcome...
Preterm delivery is a powerful predictor of newborn morbidity and mortality. Such problems are due to not only immaturity but also the pathologic factors (such as infection) that cause early delivery. The understanding these underlying incomplete at best. To extent unmeasured pathologies triggering preterm directly harm fetus, they will confound association with neonatal outcomes. This, in turn, complicates studies outcomes more generally. When investigators analyze risk outcomes, adjustment...
To provide an updated US birth weight for gestational age reference corrected likely errors in last menstrual period (LMP)-based dating, as well means and SDs, to enable calculation of continuous categorical measures age.From the 2009-2010 live files, we abstracted singleton births between 22 44 weeks gestation with at least 1 nonmissing estimate (ie, LMP or obstetric/clinical) weight. Using algorithm based on concordance these estimates, implausible LMP-based estimates were either excluded...
More than 10% of babies are born to couples taking >1 year conceive (a common definition infertility). Some evidence indicates that such pregnancies at increased risk preterm delivery and other adverse birth outcomes, but the problem has rarely been addressed in large, longitudinal studies enrolling irrespective infertility treatment.We used data from Danish National Birth Cohort: 55 906 singleton live births women who reported their waiting time pregnancy (TTP) covariates an interview...
Management of preeclampsia often culminates in induced delivery a very preterm infant. While early termination protects the fetus from an intrauterine death, newborn then faces increased risks associated with delivery. This practice has recent decades, but its net effect on fetal and infant survival not been assessed.To assess rates preeclamptic pregnancies.Population-based observational longitudinal study using registry data 804 448 singleton first-born infants Norwegian-born mothers...
To examine the association between pesticide use during pregnancy and gestational diabetes mellitus (GDM) among wives of licensed applicators.
Hypertensive disorders of pregnancy are more frequent in primiparous women, but may be severe multiparas. We examined trends stillbirth and neonatal mortality related to pregnancy-induced hypertension (PIH), explored whether varied by parity maternal race.We carried out a population-based study 57 million singleton live births stillbirths (24-46 weeks' gestation) the United States between 1990 2004. estimated rates adjusted odds ratios (ORs) death relation PIH, comparing 1990-1991 with...
We examined twinning and fetal gender in births of women with a hospital diagnosis pre-eclampsia or hyperemesis. also investigated sex ratio infants whose mothers had hyperemesis different pregnancy. From all the hospitalized cases Denmark between 1980 1996 we extracted 6,227 24,764 pre-eclampsia. Twins were more frequent pregnancies either condition. The male to female was 1.04 (95%CI = 1.02-1.05) reference population, 0.87 (95% CI 0.82-0.91) hyperemesis, 1.10 1.07-1.12) Women slightly...
Epidemiologic studies have shown that pre-eclampsia is mainly a disease of first pregnancy, possibly associated with primipaternity. The interpregnancy interval, which strongly change partner, has received little attention. In this study, based on Danish hospital records, we evaluated whether the interval may confound or modify paternal effect pre-eclampsia. We studied outcome second birth in cohort women previous (8,401 women) and all (but not first) together sample two births (26,596...
Shift work has been associated with various unfavorable pregnancy outcomes (ie, loss, spontaneous abortion, low birth weight, etc). The suggested underlying mechanism is the interference of shift circadian regulation human metabolism and, in particular, temporal pattern endocrine function. To analyze effect on fecundity, Time Unprotected Intercourses (TUI) measured couples recruited European Studies Infertility and Subfecundity, which were undertaken seven countries. A (odds ratio < 2.0) but...
Spontaneous mutations in germ cells increase with male age, but an association between paternal age and congenital malformations is not well established. We conducted a population-based cohort study to estimate this association.A population of couples their firstborn children were identified the Danish Fertility Database 1980 1996 (n = 71937). Diagnoses obtained by linkage nationwide hospital register (1980-1999).Overall, there no differences prevalence as function age. However, extremities...
The association between birth weight and mortality is among the strongest seen in epidemiology. While preterm delivery causes both small babies high mortality, it does not explain this association. Fetal growth restriction has also been proposed, although its features are unclear because lacks a definition independent of weight. If, as some postulate, itself on causal path to relation with would have be explained by confounding factors that decrease increase mortality. In paper, authors...
Deaths among preterm births are presumably due to both immaturity and the conditions that cause birth. Their relative contributions unknown.Using US birth certificates (1995-2002), we estimated what portion of neonatal mortality may be attributable alone. Twins have elevated mortality, yet they usually lower than singletons at most weeks. Twinning itself is a early Thus, any given week, more likely twins pathologic causes delivery. If such associated with risk higher conferred by twinning,...
Meta-analyses of observational studies have shown that women with a shorter interpregnancy interval (the time from delivery to start subsequent pregnancy) are more likely experience adverse pregnancy outcomes, such as preterm or small for gestational age birth, than who space their births further apart. However, the used inform these estimates methodological shortcomings.In this commentary, we summarise discussions an expert workgroup describing good practices design, analysis, and...
A long interpregnancy interval is associated with preeclampsia. If some women experiencing a between births had difficulty conceiving, subfecundity and preeclampsia may share common etiology. Therefore, the authors examined association By using interview data collected during second trimester of pregnancy (1998-2001) from participating in Danish National Birth Cohort, they identified 20,034 24,698 singleton livebirths to primiparous multiparous women, respectively, for whom information was...
Studies in the United States have indicated that maternal first trimester smoking and infant transforming growth factor alpha (TGFA) locus mutations are associated with non-syndromic cleft lip and/or palate (CLP) a synergistic effect of these two risk factors occurs. Based on Danish case-control study CLP, authors studied effects TGFA alleles an ethnically homogeneous setting. Interview information was obtained for mothers 302 CLP cases (96% eligible) 567 nonmalformed children (94%...
Background: Carbonated beverage consumption has been linked with diabetes, hypertension, and kidney stones, all risk factors for chronic disease. Cola beverages, in particular, contain phosphoric acid have associated urinary changes that promote stones. Methods: We examined the relationship between carbonated beverages (including cola) disease, using data from 465 patients newly diagnosed disease 467 community controls recruited North Carolina 1980 1982. Results: Drinking 2 or more colas per...