A5090271415- Osteoarthritis Treatment and Mechanisms
- Mental Health Treatment and Access
- Child and Adolescent Psychosocial and Emotional Development
- Smoking Behavior and Cessation
- Schizophrenia research and treatment
- Child and Adolescent Health
- Adolescent and Pediatric Healthcare
- Suicide and Self-Harm Studies
- Digital Mental Health Interventions
- School Health and Nursing Education
- Diversity and Career in Medicine
- Health Promotion and Cardiovascular Prevention
- Health disparities and outcomes
- Tracheal and airway disorders
- Infant Development and Preterm Care
- Global Public Health Policies and Epidemiology
- Lower Extremity Biomechanics and Pathologies
- Pituitary Gland Disorders and Treatments
- Obesity, Physical Activity, Diet
- Adolescent Sexual and Reproductive Health
- Autism Spectrum Disorder Research
- Genomic variations and chromosomal abnormalities
- Heat shock proteins research
- Hormonal Regulation and Hypertension
- Endoplasmic Reticulum Stress and Disease
University of Maryland, Baltimore
2013-2025
University of Pennsylvania
2025
Society for Maternal-Fetal Medicine
2023
Madigan Army Medical Center
2022-2023
University of Maryland, College Park
2015-2022
John Wiley & Sons (United Kingdom)
2022
eHealth Initiative
2022
Johns Hopkins University
2021
American Academy of Child and Adolescent Psychiatry
2021
University of South Carolina
2021
To determine the efficacy of community water-based therapy for management lower limb osteoarthritis (OA) in older patients.A pre-experimental matched-control study was used to estimate exercise treatment, check design assumptions and delivery processes. The main a randomised controlled trial effectiveness (treatment) compared with usual care (control) patients hip and/or knee OA. latter accompanied by an economic evaluation comparing societal costs consequences two treatments.Water delivered...
Aim To examine individual variability between perceived physical features and hormones of pubertal maturation in 9–10-year-old children as a function sociodemographic characteristics. Methods Cross-sectional metrics puberty were utilized from the baseline assessment Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample 9–10 year-olds (n = 11,875)—and included via development scale (PDS) child salivary hormone levels (dehydroepiandrosterone testosterone all, estradiol...
Antipsychotics are used for many psychiatric conditions in youth. Although developmentally inappropriate weight gain and metabolic abnormalities, which risk factors premature cardiovascular mortality, especially frequent youth, optimal strategies to reduce pediatric antipsychotic‐induced overweight/obesity unclear. The Improving Metabolic Parameters Antipsychotic Child Treatment (IMPACT) was a randomized, parallel group, 24‐week clinical trial enrolled overweight/obese, psychiatrically...
Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to requiring urgent medical intervention. In the case of brain magnetic resonance (MRI), reliable data about prevalence significance IFs in general population limited, making it difficult anticipate, communicate, manage these findings.To determine overall MRI nonclinical pediatric as well rates specific for which clinical referral is recommended.This cohort study was...
Mutant matrilin-3 (V194D) forms non-native disulphide bonded aggregates in the rER of chondrocytes from cell and mouse models multiple epiphyseal dysplasia (MED).Intracellular retention mutant causes endoplasmic reticulum (ER) stress induces an unfolded protein response (UPR) including upregulation two genes recently implicated ER stress: Armet Creld2.Nothing is known about role Creld2 human genetic diseases.In this study, we used a variety chondrodysplasia to determine genotype-specific...
Early detection and prevention of psychosis has become an international priority. Much this work focused on youth presenting with attenuated symptoms psychosis-those at Clinical High Risk for (CHR)-given their elevated probability developing the full disorder in subsequent years. Individuals CHR may be prone to exacerbated psychological distress during COVID-19 pandemic its physical isolation measures, due heightened stress sensitivity comorbid mental health problems. Telepsychotherapy holds...
Acute patient physiologic and laboratory evaluation (APPLE) scores have not been reported in dogs with diabetic ketoacidosis (DKA). The APPLE will be higher non-survivors compared survivors, predict increased mortality DKA. Eighty-five DKA; 58 survivors (68%) 27 (32%). Retrospective study. were entered into a multivariate logistic regression model for prediction. Variables related to DKA diagnosis also examined as predictors. If variables predicted mortality, an empirical optimal cut point,...
Umbilical cord matrix stem (UCMS) cells that were engineered to express interferon-beta (IFN-β) transplanted weekly for three weeks into MDA 231 breast cancer xenografts bearing SCID mice in combination with 5-fluorouracil (5-FU). The UCMS found within lung tumors but not other tissues. Although both treatments significantly reduced tumor area the mouse lungs, combined treatment resulted a greater reduction than by either used alone. These results indicate of UCMS-IFN-β and 5-FU is...
Pseudoachondroplasia (PSACH) results from mutations in cartilage oligomeric matrix protein (COMP) and the p.D469del mutation within type III repeats of COMP accounts for approximately 30% PSACH. To determine disease mechanisms PSACH vivo, we introduced Comp D469del into mouse genome. Mutant animals were normal at birth but grew slower than their wild-type littermates developed short-limb dwarfism. In growth plates mutant mice chondrocyte columns reduced number poorly organized, while was...
The number of people living with dementia is growing, leading to increasing pressure upon care providers. mechanisms reduce symptoms can take many forms and have the aim improving wellbeing quality life person those who for them. Besides has dementia, condition a profound impact their loved ones carers. One therapeutic approach use music, an area recognised as having potential benefit, but requiring further research. present paper reports mixed methods cohort study that examines musical...
We investigated if reluctance to seek help could be explained by how people perceive an illness. Participants were members of the general public who had experienced mental health problems, for which approximately half sought professional help. asked them rate problems 2 vignette characters using Brief Illness Perception Questionnaire (BIPQ). more likely see as having serious consequences and understand their better, compared with those not The depression character was seen a problem that but...
Objectives Domestic violence screening is advocated in some healthcare settings. Evidence that it increases referral to support agencies or improves health outcomes limited. This study aimed (1) investigate the proportion of hospital patients reporting domestic violence, (2) describe characteristics and previous attendances affected (3) assess referrals an in-house advisor from Camden Safety Net. Design A series observational studies. Setting Three outpatient clinics at Royal Free London NHS...
A study was carried out to identify the characteristics of children who do not attend appointments at general outpatient clinics. Over six months, 359 had an appointment a clinic were studied using questionnaire given parents (74% response rate) and by inspection case notes. Based on their first in period, divided into 'attenders' (n = 262) 'non-attenders' 97) for analysis. Non-attenders significantly more likely have one or following characteristics: lower social class, poorer housing,...
Experiencing psychosis-spectrum symptoms is challenging to youth. Among many difficulties, internalized mental health stigma-the internalization of negative stereotypes-can lead shame and withdrawal. The objective this study was better understand the correlates stigma among a clinical sample youth with symptoms. Participants (n = 66; 12-25 years old) were referred by community providers in Maryland, United States. Psychosis-spectrum measured via Structured Interview for Psychosis-Risk...
Cysteine-rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER)-resident chaperone highly activated under ER stress in conditions such as chondrodysplasias; however, its role healthy skeletal development unknown. We show for the first time that cartilage-specific deletion of Creld2 results disrupted endochondral ossification and short limbed dwarfism, whereas bone osteopenia, a low density altered trabecular architecture. Our study provides evidence...
Abstract The mouse zinc‐finger gene Zfp521 (also known as ecotropic viral insertion site 3; Evi3 ; and ZNF521 in humans) has been identified a B‐cell proto‐oncogene, causing leukemia mice following retroviral insertions its promoter region that drive over‐expression. Furthermore, is expressed human hematopoietic cells, translocations between PAX5 are associated with pediatric acute lymphoblastic leukemia. However, the regulatory factors control expression directly have not characterized....
Abstract Zika virus infection can result in devastating pregnancy outcomes when it crosses the placental barrier. For human pregnancies, mechanisms of vertical transmission remain enigmatic. Utilizing a placenta-cotyledon perfusion model, we examined exposure absence maternal factors. To distinguish responses related to viral vs . recognition, evaluated cotyledons perfused with either active or inactivated virus. Active resulted infection, cell death and syncytium injury. Pathology...