A5057767291- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Advanced NMR Techniques and Applications
- Treatment of Major Depression
- Impact of Technology on Adolescents
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Tryptophan and brain disorders
- Electrolyte and hormonal disorders
- Schizophrenia research and treatment
- Child Development and Digital Technology
- Biochemical effects in animals
- Optical Imaging and Spectroscopy Techniques
- Neuroscience of respiration and sleep
- Neurological and metabolic disorders
- Forensic Toxicology and Drug Analysis
- Mitochondrial Function and Pathology
- Stress Responses and Cortisol
- High Altitude and Hypoxia
- Suicide and Self-Harm Studies
- Atomic and Subatomic Physics Research
University of Utah
2016-2025
Mental Illness Research, Education and Clinical Centers
2016-2025
Star Center
2015-2025
Huntsman Cancer Institute
2022-2024
Huntsman (United States)
2024
George E. Wahlen Department of VA Medical Center
2018-2024
VA Rocky Mountain Network
2013-2023
United States Department of Veterans Affairs
2009-2023
VA Salt Lake City Healthcare System
2009-2022
Allen Institute for Brain Science
2009-2021
To test by MRI-based morphometry the a priori hypotheses that developmental anomalies exist in attention-deficit hyperactivity disorder (ADHD) left caudate and right prefrontal/frontal/ and/or posterior parietal hemispheric regions, accord with neurochemical, neuronal circuitry attentional network hypotheses, prior imaging studies.Case-control study.Academic medical center.Fifteen male subjects ADHD without comorbid diagnoses (aged 12.4 +/- 3.4 years) 15 normal controls 14.4 3.4),...
Yoga and exercise have beneficial effects on mood anxiety. γ-Aminobutyric acid (GABA)-ergic activity is reduced in anxiety disorders. The practice of yoga postures associated with increased brain GABA levels. This study addresses the question whether changes mood, anxiety, levels are specific to or related physical activity.Healthy subjects no significant medical/psychiatric disorders were randomized a metabolically matched walking intervention for 60 minutes 3 times week 12 weeks. Mood...
Bipolar disorder (BD) has substantial morbidity and incompletely understood neurobiological underpinnings.To investigate brain chemistry in medication-free individuals with BD.Two-dimensional proton echo-planar spectroscopic imaging (PEPSI) (32 x 32, 1-cm(3) voxel matrix) acquired axially through the cingulate gyrus was used to quantify regional chemistry.The Center for Anxiety Depression at University of Washington Seattle Research Programs McLean Hospital Massachusetts General...
A dramatic increase in the use and dependence of prescription opioids has occurred within last 10 years. The consequences long-term opioid on brain are largely unknown, any speculation is inferred from heroin methadone studies. Thus, no data have directly demonstrated effects structure function humans. To pursue this issue, we used structural magnetic resonance imaging, diffusion tensor imaging resting-state functional a highly enriched group opioid-dependent patients [(n = 10); larger study...
The aim of this study was to compare changes in brain gamma-aminobutyric (GABA) levels associated with an acute yoga session versus a reading session. It hypothesized that individual would be increase GABA levels.This is parallel-groups design.Screenings, scan acquisitions, and interventions took place at medical school-affiliated centers.The sample comprised 8 practitioners 11 comparison subjects.Yoga completed 60-minute subjects session.GABA-to-creatine ratios were measured 2-cm axial slab...
Bupropion has been used in the treatment of patients with substance dependence based on its weak inhibition dopamine and norepinephrine reuptake. We hypothesized that 6 weeks bupropion sustained release (SR) would decrease craving for Internet game play as well video cue-induced brain activity addiction (IAG). Eleven subjects who met criteria IAG, playing StarCraft (>30 hr/week), eight healthy comparison (HC) had experience (<3 days/week <1 hr/day). At baseline at end SR treatment, response...
Research into environmental factors associated with suicide has historically focused on meteorological variables. Recently, a heightened risk of related to short-term exposure airborne particulate matter was reported. Here, we examined the associations between nitrogen dioxide, matter, and sulfur dioxide completed in Salt Lake County, Utah (n = 1,546) from 2000 2010. We used time-stratified case-crossover design estimate adjusted odds ratios for relationship air pollutants day during days...
The effects of type 1 diabetes and key metabolic variables on brain structure are not well understood. Sensitive methods assessing structure, such as voxel-based morphometry (VBM), have previously been used to investigate central nervous system changes in a diabetic population. Using VBM, we compared patients aged 25–40 years with disease duration 15–25 minimal complications an age-matched, nondiabetic control group. We investigated whether lower than expected gray matter densities were...
Objective: This study was conducted to explore differences in cortical thickness between subjects with bipolar disorder and healthy comparison using surface‐based analysis. Methods: Brain magnetic resonance images were acquired from 25 21 subjects. Cortical analysis the Freesurfer application. Group thickness, defined by distance gray/white boundary pial surface, assessed statistical difference maps. Results: Subjects exhibited significantly decreased left cingulate cortex, middle frontal...
This study was undertaken to test the feasibility of using functional magnetic resonance imaging (MRI) examine changes in cortical activation response verbal tasks two brain regions.Twelve schizophrenic patients and 11 comparison subjects underwent MRI frontal temporal lobes. Stimulus sequences were divided into five 30-second segments by a task-activation paradigm that alternated between resting stimulated states. Functional images collected every 30 seconds gradient echo pulse...
Excessive internet video game play (EIGP) has emerged as a leading cause of behavioral and developmental problems in adolescents. Recent research implicated the role striatal dopaminergic system maladaptations associated with EIGP. This study investigates reward-dependence characteristics EIGP adolescents it potentially relates to genetic polymorphisms temperament. Seventy-nine male 75 age- gender-matched healthy comparison were recruited. Associations tested respect (RD) scale Cloninger's...