A5050372398- Pain Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Treatment of Major Depression
- Ion Transport and Channel Regulation
- Pain Management and Treatment
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Erythrocyte Function and Pathophysiology
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Neurotransmitter Receptor Influence on Behavior
- Cancer Research and Treatments
- Iron Metabolism and Disorders
- Neuropeptides and Animal Physiology
- Opioid Use Disorder Treatment
- Adipose Tissue and Metabolism
- Hemoglobinopathies and Related Disorders
- Blood Pressure and Hypertension Studies
- Pain Management and Placebo Effect
- Trigeminal Neuralgia and Treatments
Dartmouth–Hitchcock Medical Center
2021-2024
Dartmouth College
2021-2023
Dartmouth Hospital
2023
University of Minnesota
2015-2021
McLean Hospital
2009-2015
Imaging Center
2009-2015
Center for Pain and the Brain
2013
Harvard University
2010-2013
Massachusetts General Hospital
2013
United States Military Academy
2013
A dramatic increase in the use and dependence of prescription opioids has occurred within last 10 years. The consequences long-term opioid on brain are largely unknown, any speculation is inferred from heroin methadone studies. Thus, no data have directly demonstrated effects structure function humans. To pursue this issue, we used structural magnetic resonance imaging, diffusion tensor imaging resting-state functional a highly enriched group opioid-dependent patients [(n = 10); larger study...
Complex regional pain syndrome (CRPS) in paediatric patients is clinically distinct from the adult condition which there often complete resolution of its signs and symptoms within several months to a few years. The ability compare symptomatic asymptomatic same individuals makes this population interesting for investigation mechanisms underlying other CRPS. We used fMRI evaluate CNS activation (9–18 years) with CRPS affecting lower extremity. Each patient underwent two scanning sessions: once...
Previous reports have indicated that ketamine anesthesia may produce significant improvement if not complete recovery of patients with complex regional pain syndrome (CRPS).Here we report on a patient who had CRPS affecting mainly the right side her body underwent functional magnetic resonance imaging (fMRI) scans prior to and in months following apparent successful treatment anesthetic doses ketamine.The two sessions: one during state (CRPS+) 1 month after pain-free (CRPS-). Both...
The primary objective of this study was to compare the antihypertensive efficacy and safety intravenously administered nicardipine with that intravenous nitroprusside (SNP) in patients severe hypertension. conducted 121 hypertension (diastolic blood pressure [BP] > 120 mm Hg, or systolic BP 200 Hg). Patients were randomized receive SNP. Drugs according a predetermined dosing schedule for 10 12 h period. Sixty-one 60 Pretreatment values SNP groups 217/128 Hg 219/128 respectively. Therapeutic...
Pharmacological magnetic resonance imaging (phMRI) is one method by which a drug's pharmacodynamic effects in the brain can be assessed. Although phMRI has been frequently used preclinical and clinical settings, extent to signature for compound translates between rodents humans not systematically examined. In current investigation, we aimed build on recent work functional response 0.1 0.2 mg/70 kg i.v. buprenorphine (partial <i>µ</i>-opioid receptor agonist) was measured healthy humans....
Nalbuphine, an agonist-antagonist kappa-opioid, produces brief analgesia followed by enhanced pain/hyperalgesia in male postsurgical patients. However, it profound without pain enhancement when co-administration with low dose naloxone. To examine the effect of nalbuphine or plus naloxone on activity brain regions that may explain these differences, we employed pharmacological magnetic resonance imaging (phMRI) a double blind cross-over study 13 healthy volunteers. In separate sessions...
Glioblastoma is the most common primary malignant and treatment-resistant human brain tumor. Rodent models have played an important role in understanding cancer biology treatment. However, due to their small cranium tumor volume mismatch, relative disease, they been less useful for translational studies. Therefore, development of a consistent simple large animal glioma xenograft model would significant benefits. Immunosuppression was induced twelve standard Yucatan minipigs. 3 pigs received...
Using functional magnetic resonance imaging (fMRI) methods, we evaluated the effects of lamotrigine vs placebo in a double-blind 1:1 randomized trial. Six patients with neuropathic pain were recruited for study. All subjects had baseline >4/10 on visual analog scale (VAS) and allodynia to brush as inclusion criteria Patients underwent two fMRI sessions, half receiving first drug (based blinding protocol). Lamotrigine decreased their average intensity level from 5.6 3.5 VAS. brush, cold, heat...
Background. Previous reports have indicated that ketamine anesthesia may produce significant improvement if not complete recovery of patients with complex regional pain syndrome (CRPS). Aims. Here we report on a patient who had CRPS affecting mainly the right side her body underwent functional magnetic resonance imaging (fMRI) scans prior to and in months following apparent successful treatment anesthetic doses ketamine. Materials Methods. The two sessions: one during state (CRPS+) 1 month...
Abstract Maternal immune activation (MIA) is strongly associated with an increased risk of developing mental illness in adulthood, which often co-occurs alcohol misuse. The current study aimed to begin determine whether MIA, combined adolescent exposure (AE), could be used as a model we the neurobiological mechanisms behind such co-occurring disorders. Pregnant Sprague-Dawley rats were treated polyI:C or saline on gestational day 15. Half offspring given continuous access during adolescence,...
Resting-state functional magnetic resonance imaging (rs-fMRI) has become an increasingly popular method to study brain function in a resting, non-task state. This protocol describes preclinical survival for obtaining rs-fMRI data. Combining low dose isoflurane with continuous infusion of the α2 adrenergic receptor agonist dexmedetomidine provides robust option stable, high-quality data acquisition while preserving network function. Furthermore, this procedure allows spontaneous breathing and...
Resting-state functional magnetic resonance imaging (rs-fMRI) has become an increasingly popular method to study brain function in a resting, non-task state. This protocol describes preclinical survival for obtaining rs-fMRI data. Combining low dose isoflurane with continuous infusion of the α2 adrenergic receptor agonist dexmedetomidine provides robust option stable, high-quality data acquisition while preserving network function. Furthermore, this procedure allows spontaneous breathing and...
Nicotine and alcohol use is highly prevalent among patients with serious mental illness, including those schizophrenia (SCZ), this co-occurrence can lead to a worsening of medical psychiatric morbidity. While the mechanistic drivers co-occurring SCZ, nicotine are unknown, emerging evidence suggests that drugs during adolescence may increase probability developing disorders. The current study used neonatal ventral hippocampal lesion (NVHL) rat model which has previously been shown have...
Background: Glioblastoma is the most common primary malignant and treatment-resistant human brain tumor. Rodent models have played an important role in understanding cancer biology treatment. However, due to their small cranium tumor volume mismatch, relative disease, they been less useful for translational studies. Therefore, development of a consistent simple large animal glioma xenograft model would significant benefits. Methods: Immunosuppression was induced twelve standard Yucatan...
Abstract Maternal immune activation (MIA) is strongly associated with an increased risk of developing mental illness in adulthood, which often co-occurs alcohol misuse. The current study aimed to begin determine whether MIA, combined adolescent exposure (AE), could be used as a model we the neurobiological mechanisms behind such co-occurring disorders. Pregnant Sprague-Dawley rats were treated PolyI:C or saline on gestational day 15. Half offspring given continuous access during adolescence,...