A5104010455- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Advanced MRI Techniques and Applications
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Circadian rhythm and melatonin
- Nicotinic Acetylcholine Receptors Study
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Receptor Mechanisms and Signaling
University of North Carolina at Chapel Hill
2024
Dartmouth College
2018-2022
Dartmouth–Hitchcock Medical Center
2021
Randolph–Macon College
2019
Ashland (United States)
2019
Abstract Background Alcohol is commonly consumed by adolescents in a binge‐like pattern, which can lead to long‐lasting cognitive deficits, including reduced behavioral flexibility. We and others have determined that adolescent intermittent ethanol (AIE) exposure leads increased number of perineuronal net (PNN) numbers brain regions are important for However, whether altered neurochemistry stemming from AIE plays significant role flexibility unknown. Methods measured the size parvalbumin...
Abstract Maternal immune activation (MIA) is strongly associated with an increased risk of developing mental illness in adulthood, which often co-occurs alcohol misuse. The current study aimed to begin determine whether MIA, combined adolescent exposure (AE), could be used as a model we the neurobiological mechanisms behind such co-occurring disorders. Pregnant Sprague-Dawley rats were treated polyI:C or saline on gestational day 15. Half offspring given continuous access during adolescence,...
Abstract Background Although male and female rats differ in their patterns of alcohol use, little is known regarding the neural circuit activity that underlies these differences behavior. The current study used a machine learning approach to characterize sex local field potential (LFP) oscillations may relate alcohol-drinking Methods LFP were recorded from nucleus accumbens shell rodent medial prefrontal cortex adult Sprague-Dawley rats. Recordings occurred before exposed ( n = 10/sex × 2...
Image courtesy of Frances CohenDr. Alan I. Green, a pioneer in the fields neuropsychopharmacology and dual diagnosis, passed away on Thanksgiving Day, 2020, after long battle with cancer. Dr. ...
Resting-state functional magnetic resonance imaging (rs-fMRI) has become an increasingly popular method to study brain function in a resting, non-task state. This protocol describes preclinical survival for obtaining rs-fMRI data. Combining low dose isoflurane with continuous infusion of the α2 adrenergic receptor agonist dexmedetomidine provides robust option stable, high-quality data acquisition while preserving network function. Furthermore, this procedure allows spontaneous breathing and...
Resting-state functional magnetic resonance imaging (rs-fMRI) has become an increasingly popular method to study brain function in a resting, non-task state. This protocol describes preclinical survival for obtaining rs-fMRI data. Combining low dose isoflurane with continuous infusion of the α2 adrenergic receptor agonist dexmedetomidine provides robust option stable, high-quality data acquisition while preserving network function. Furthermore, this procedure allows spontaneous breathing and...
Nicotine and alcohol use is highly prevalent among patients with serious mental illness, including those schizophrenia (SCZ), this co-occurrence can lead to a worsening of medical psychiatric morbidity. While the mechanistic drivers co-occurring SCZ, nicotine are unknown, emerging evidence suggests that drugs during adolescence may increase probability developing disorders. The current study used neonatal ventral hippocampal lesion (NVHL) rat model which has previously been shown have...
Abstract Background Although male and female rats differ in their patterns of alcohol use, little is known regarding the neural circuit activity that underlies these differences behavior. The current study used a machine learning approach to characterize sex local field potential (LFP) oscillations may relate drinking Methods LFP were recorded from nucleus accumbens shell rodent medial prefrontal cortex adult Sprague-Dawley rats. Recordings occurred before exposed (n=10/sex X 2...
Abstract Maternal immune activation (MIA) is strongly associated with an increased risk of developing mental illness in adulthood, which often co-occurs alcohol misuse. The current study aimed to begin determine whether MIA, combined adolescent exposure (AE), could be used as a model we the neurobiological mechanisms behind such co-occurring disorders. Pregnant Sprague-Dawley rats were treated PolyI:C or saline on gestational day 15. Half offspring given continuous access during adolescence,...