A5049669065- Neural and Behavioral Psychology Studies
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience and Neuropharmacology Research
- Substance Abuse Treatment and Outcomes
- Memory and Neural Mechanisms
- Mental Health Research Topics
- Mindfulness and Compassion Interventions
- Decision-Making and Behavioral Economics
- Stress Responses and Cortisol
- Behavioral Health and Interventions
- Attention Deficit Hyperactivity Disorder
- Animal Vocal Communication and Behavior
- Prenatal Substance Exposure Effects
- Advanced MRI Techniques and Applications
- COVID-19 and Mental Health
- Animal Behavior and Reproduction
- Nicotinic Acetylcholine Receptors Study
- Heart Rate Variability and Autonomic Control
- Marine animal studies overview
- Child and Adolescent Psychosocial and Emotional Development
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience, Education and Cognitive Function
University of North Carolina at Chapel Hill
2016-2025
Imaging Center
2016-2025
Florida State University
2017
Indiana University School of Medicine
2011-2016
Institut des Sciences Cognitives Marc Jeannerod
2016
Laboratoire d’Imagerie Biomédicale
2014
Ernest Gallo Clinic and Research Center
2004-2011
University of California, San Francisco
1998-2011
University of California, Berkeley
1995-2011
University of Colorado Boulder
2011
Abstract Mindfulness training may disrupt the risk chain of stress-precipitated alcohol relapse. In 2008, 53 alcohol-dependent adults (mean age = 40.3) recruited from a therapeutic community located in urban southeastern U.S. were randomized to mindfulness or support group. Most participants male (79.2%). African American (60.4%), and earned less than $20,000 annually (52.8%). Self-report measures, psychophysiological cue-reactivity, attentional bias analyzed via repeated measures ANOVA....
The tendency to choose lesser immediate benefits over greater long-term characterizes alcoholism and other addictive disorders. However, despite its medical socioeconomic importance, little is known about neurobiological mechanisms. Brain regions that are activated when deciding between or delayed rewards have been identified (McClure et al., 2004, 2007), as areas in which responses reward stimuli predict a paper-and-pencil measure of temporal discounting (Hariri 2006). These studies assume...
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental characterized by hyperactivity/impulsivity and inattentiveness. Efforts toward the development of biologically based diagnostic test have identified differences in EEG power spectrum; most consistently reported an increased ratio theta to beta during resting state those with disorder, compared controls. Current approaches calculate theta/beta using fixed frequency bands, but observed may be confounded other...
Abstract: Background: Impaired decision-making is one diagnostic characteristic of alcoholism. Quantifying with rapid and robust laboratory-based measures thus desirable for the testing novel treatments Previous research has demonstrated utility delay discounting (DD) tasks quantifying differences in substance abusers normal controls. In DD paradigms subjects choose between a small, immediate reward larger, delayed reward. Methods: We used computerized task to demonstrate that abstinent...
Flexible rule learning, a behavior with obvious adaptive value, is known to depend on an intact prefrontal cortex (PFC). One simple, yet powerful, form of such learning consists forming arbitrary stimulus-response (S-R) associations. A variety evidence from monkey and human studies suggests that the PFC plays important role in both new S-R associations using learned rules select contextually appropriate response particular stimulus cue. Although lesion more strongly implicate ventrolateral...
A variety of evidence suggests that, among humans, the individual tendency to choose immediate rewards (“Now”) over larger, delayed (“Later”), or Now bias, varies with frontal dopamine (DA) levels. As cyclic elevations in estradiol (E+) modulate other DA-dependent behaviors, we tested ovarian cycle effects on and whether any such are E+ mediated. To do so, quantified / Later choice behavior naturally cycling adult females ( n = 87; ages 18–40 years) during both menstrual phase (MP; day 1–2;...
Abstract Learned habitual responses to environmental stimuli allow efficient interaction with the environment, freeing cognitive resources for more demanding tasks. However, when outcome of such actions is no longer a desired goal, established stimulus–response (S-R) associations or habits must be overcome. Among people substance use disorders (SUDs), difficulty in overcoming associated their addiction favor new, goal-directed behaviors contributes relapse. Animal models habit learning...
Alcohol use among adolescents is widespread and a growing concern due to long-term behavioral deficits, including altered Pavlovian behavior, that potentially contribute addiction vulnerability. We tested the hypothesis adolescent intermittent ethanol (AIE) exposure alters behavior in males females as measured by shift from goal-tracking sign-tracking. Additionally, we investigated GLT-1, an astrocytic glutamate transporter, potential contributor sign-tracking phenotype.Male female...
Abstract Background Binge alcohol exposure during adolescence results in long‐lasting alterations the brain and behavior. For example, adolescent intermittent ethanol (AIE) rodents long‐term loss of functional connectivity among prefrontal cortex (PFC) striatal regions as well a variety neurochemical, molecular, epigenetic alterations. Interneurons PFC striatum play critical roles behavioral flexibility connectivity. parvalbumin (PV) interneurons are known to contribute neural synchrony...
Abstract Background Hazardous use of alcohol is associated with cognitive‐behavioral impairments and accelerated aging. To date, however, brain aging has not been tested as a mediating factor between task‐based behavioral deficits, such inflexibility. Here, we evaluated hazardous predictor machine learning‐derived if this measure accounted for the relationship flexibility. Methods In secondary analysis, applied brainageR , learning algorithm, to anatomical T1‐weighted magnetic resonance...
Converging evidence links individual differences in mesolimbic and mesocortical dopamine (DA) to variation the tendency choose immediate rewards (“ Now”) over larger, delayed Later”), or “ Now bias.” However, date, no study of healthy young adults has evaluated relationship between bias DA with positron emission tomography (PET). Sixteen (ages 24–34 yr; 50% women) completed a delay-discounting task that quantified aspects intertemporal reward choice, including magnitude sensitivity....
Nicotine exposure enhances Pavlovian conditioned approach (PCA), or the learned to reward-predictive cues. While females show elevated stimuli compared males, potentially indicating heightened addiction vulnerability, it is unknown how sex may interact with nicotine influence behavior. Additionally, brain-derived neurotrophic factor (BDNF) levels can be altered significantly after repeated exposure, suggesting a potential mechanism contributing nicotine-induced behavioral phenotypes. The...
Resting-state functional magnetic resonance imaging (fMRI) has drastically expanded the scope of brain research by advancing our knowledge about topologies, dynamics, and interspecies translatability networks. Several databases have been developed shared in accordance with recent key initiatives rodent fMRI community to enhance transparency, reproducibility, interpretability data acquired at various sites. Despite these pioneering efforts, one notable challenge preventing efficient...
Abstract Background Alcohol is commonly consumed by adolescents in a binge‐like pattern, which can lead to long‐lasting cognitive deficits, including reduced behavioral flexibility. We and others have determined that adolescent intermittent ethanol (AIE) exposure leads increased number of perineuronal net (PNN) numbers brain regions are important for However, whether altered neurochemistry stemming from AIE plays significant role flexibility unknown. Methods measured the size parvalbumin...