A5013319818- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Pain Management and Placebo Effect
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Anesthesia and Pain Management
- Musculoskeletal pain and rehabilitation
- Pain Management and Opioid Use
- Botulinum Toxin and Related Neurological Disorders
- Sleep and Wakefulness Research
- Pediatric Pain Management Techniques
- Neural dynamics and brain function
- Pain Management and Treatment
- Healthcare and Venom Research
- Pharmacological Receptor Mechanisms and Effects
- Regulation of Appetite and Obesity
- Ion channel regulation and function
- Substance Abuse Treatment and Outcomes
- Transcranial Magnetic Stimulation Studies
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Neural and Behavioral Psychology Studies
- Neuroendocrine regulation and behavior
- Neurobiology and Insect Physiology Research
University of California, San Francisco
2014-2023
Alcohol Research Group
2019-2021
Ernest Gallo Clinic and Research Center
2004-2013
University of California, Berkeley
2003-2012
University of Colorado Boulder
2011
University of North Carolina at Chapel Hill
2011
Imaging Center
2011
Stanford University
1965-2004
Oregon Health & Science University
1996-2003
Vollum Institute
2003
Numerous human and animal studies indirectly implicate neurons in the anterior cingulate cortex (ACC) encoding of affective consequences nociceptor stimulation. No causal evidence, however, has been put forth linking ACC specifically to this function. Using a rodent pain assay that combines hind-paw formalin model with place-conditioning paradigm, we measured learned behavior directly reflects component rat (formalin-induced conditioned place avoidance) concomitantly “acute” formalin-induced...
Abstract Small amounts of 3 H‐leucine were injected into discrete regions in the rostral medulla cat. Descending projections from these sites studied with autoradiographic methods. On basis differential to and spinal cord, three distinct delineated. Nucleus reticularis gigantocellularis (Rgc), located dorsally medullary reticular formation, projects primarily “motor” related sites, including cranial motor nuclei VI, VII, XII, nucleus intercalatus, a part ipsilateral medial accessory olive....
There is considerable evidence that the dorsolateral funiculus (DLF) of spinal cord contains descending pathways critical for both opiate and brainstem stimulation-produced analgesia. To obtain a comprehensive map neurons projecting to via DLF, large injections horseradish peroxidase (HRP) were made into lumbosacral cat rat. These caudal midthoracic lesions which spared only single DLF or ventral quadrant (VQ); thus those whose axons descended in would be labelled. Cells with VQ concentrated...
The ventral tegmental area (VTA) and in particular VTA dopamine (DA) neurons are postulated to play a central role reward, motivation drug addiction. However, most evidence implicating DA these functions is based on indirect electrophysiological characterization, rather than cytochemical identification. These physiological criteria were first established the substantia nigra pars compacta (SNc), but their validity uncertain. In current study we found that while 88 ± 2% of SNc labelled by...
We studied the analgesic efficacy of an intravenous infusion lidocaine and morphine in 19 adults with well-established postherpetic neuralgia a three-session, randomized, double-blind, placebo-controlled trial. Compared saline placebo, both reduced pain intensity. Reductions did not correlate side effects produced by infusions. For morphine, there was significant correlation between reductions intensity blood level achieved. In majority subjects who reported definite relief, allodynia also...
We use a novel balanced experimental design to specifically investigate brain mechanisms underlying the modulating effect of expected pain intensity on afferent nociceptive processing and perception. used two visual cues, each conditioned one noxious thermal stimuli [∼48°C (high) or 47°C (low)]. The cues were presented just before during application stimulus. Subjects reported significantly higher when stimulus was preceded by high-intensity cue. To control for expectancy effects, one-half...