A5103406354- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Pain Management and Placebo Effect
- Heart Rate Variability and Autonomic Control
- Neural dynamics and brain function
- Pain Management and Treatment
- EEG and Brain-Computer Interfaces
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Opioid Use Disorder Treatment
- Neuroscience and Neuropharmacology Research
- Spine and Intervertebral Disc Pathology
- Advanced MRI Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Complex Network Analysis Techniques
- Botulinum Toxin and Related Neurological Disorders
- Mental Health Research Topics
- Neuropeptides and Animal Physiology
- Bioinformatics and Genomic Networks
- Machine Learning in Materials Science
- Nerve injury and regeneration
- Face Recognition and Perception
- Neurobiology of Language and Bilingualism
Shirley Ryan AbilityLab
2011-2025
Northwestern University
2014-2025
Pain and Rehabilitation Medicine
2015-2024
Pain Management Institute
2022
Northwestern University
2007
American University of Beirut
2004
Functional magnetic resonance imaging is used to extract functional networks connecting correlated human brain sites. Analysis of the resulting in different tasks shows that (a) distribution connections, and probability finding a link versus distance are both scale-free, (b) characteristic path length small comparable with those equivalent random networks, (c) clustering coefficient orders magnitude larger than networks. All these properties, typical scale-free small-world reflect important...
Chronic pain patients suffer from more than just pain; depression and anxiety, sleep disturbances, decision-making abnormalities (Apkarian et al., 2004a) also significantly diminish their quality of life. Recent studies have demonstrated that chronic harms cortical areas unrelated to 2004b; Acerra Moseley, 2005), but whether these structural impairments behavioral deficits are connected by a single mechanism is as yet unknown. Here we propose long-term alters the functional connectivity...
Living with unrelenting pain (chronic pain) is maladaptive and thought to be associated physiological psychological modifications, yet there a lack of knowledge regarding brain elements involved in such conditions. Here, we identify regions spontaneous chronic back (CBP) two separate groups patients ( n = 13 11), contrast activity between thermal (CBP healthy subjects, 11 each). Continuous ratings fluctuations during functional magnetic resonance imaging were separated into components: high...
Chronic pain conditions are associated with abnormalities in brain structure and function. Moreover, some studies indicate that activity related to the subjective perception of chronic may be distinct from for acute pain. However, latter based on observations cross-sectional studies. How reorganizes transition has remained unexplored. Here we study this by examining rating fluctuations back magnitude. First compared pain-related between subjects who have had condition ∼2 months no prior...
Chronic pain is associated with neuronal plasticity. Here we use resting-state functional magnetic resonance imaging to investigate changes in patients suffering from chronic back (CBP), complex regional syndrome (CRPS) and knee osteoarthritis (OA). We isolated five meaningful networks across the groups, of which only default mode network (DMN) exhibited deviations healthy controls. All patient groups showed decreased connectivity medial prefrontal cortex (MPFC) posterior constituents DMN,...
Chronic pain patients exhibit increased anxiety, depression, and deficits in learning memory. Yet how persistent affects the key brain area regulating these behaviors, hippocampus, has remained minimally explored. In this study we investigated impact of spared nerve injury (SNI) neuropathic mice on hippocampal-dependent behavior underlying cellular molecular changes. parallel, measured hippocampal volume three groups chronic patients. We found that SNI animals were unable to extinguish...
Chronic pain can be understood not only as an altered functional state, but also a consequence of neuronal plasticity. Here we use in vivo structural MRI to compare global, local, and architectural changes gray matter properties patients suffering from chronic back (CBP), complex regional syndrome (CRPS) knee osteoarthritis (OA), relative healthy controls. We find that different types exhibit unique anatomical 'brain signatures'. Only the CBP group showed whole-brain volume, while density...
SEE TRACEY DOI101093/BRAIN/AWW147 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back patients longitudinally for 3 years as they either recovered from or transitioned to pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed Intra-corticolimbic connectivity analysis identified three segregated communities: dorsal medial prefrontal...
Chronic pain is maladaptive and influences brain function behavior by altering the flow integration of information across regions. Here we use a power spectral analysis to investigate impact presence chronic on oscillatory activity in humans. We examine changes BOLD fluctuations, different frequencies, back (CBP) patients ( n = 15) as compared healthy controls during resting-state fMRI. While subjects exhibited specific, frequency band-dependent, large-scale neural organization, showed...
Brain oscillatory activity has long been thought to have spatial properties, the details of which are unresolved. Here we examine organizational rules for human brain as measured by blood oxygen level-dependent (BOLD) signal. Resting-state BOLD signal was transformed into frequency space (Welch's method) and averaged across subjects, its distribution studied a function four bands, spanning full bandwidth. The showed anatomically constrained power each band. This result replicated on...
Neural mechanisms mediating the transition from acute to chronic pain remain largely unknown. In a longitudinal brain imaging study, we followed up patients with single sub-acute back (SBP) episode for more than 1 year as their recovered (SBPr), or persisted (SBPp) representing pain. We discovered white matter structural abnormalities (n=24 SBP patients; SBPp=12 and SBPr=12), measured by diffusion tensor (DTI), at entry into study in SBPp comparison SBPr. These fractional anisotropy (FA)...
Most individuals who develop pain following an inciting event will return to a healthy state as the injury heals. However, small percentage continue suffer, that is, transition chronic pain. Chronic may persist for years and is accompanied by cognitive abnormalities, well diminished quality of life. In animals, persistent characterized peripheral spinal cord reorganization, recent evidence in humans also indicates cortical reorganization. Yet, despite more than 30 research, there little...
The hippocampus has been shown to undergo significant changes in rodent models of neuropathic pain; however, the role human chronic pain and its contribution chronification have remained unexplored. Here we examine hippocampal processing during a simple visual attention task. We used functional MRI identify intrinsic extrinsic connectivity (synchronous neural activity), comparing subacute back (SBP, 1–4 mo) (CBP, >10 yr) patients control (CON) subjects. Both groups showed more extensive...
The effects of an analgesic treatment (lidocaine patches) on brain activity in chronic low back pain (CBP) and knee osteoarthritis (OA) were investigated using serial fMRI (contrasting between before after two weeks treatment). Prior to was distinct the groups: CBP spontaneous associated mainly with medial prefrontal cortex, while OA painful mechanical stimulation bilateral thalamus, secondary somatosensory, insular, cingulate cortices, unilateral putamen amygdala. After 5% lidocaine patches...
No AccessJournal of UrologyAdult Urology1 Jul 2011Brain Functional and Anatomical Changes in Chronic Prostatitis/Chronic Pelvic Pain Syndrome Melissa A. Farmer, Mona L. Chanda, Elle Parks, Marwan N. Baliki, Vania Apkarian, Anthony J. Schaeffer FarmerMelissa Farmer Department Physiology, Feinberg School Medicine, Northwestern University, Chicago, Illinois More articles by this author , ChandaMona Chanda ParksElle Parks BalikiMarwan Baliki ApkarianA. Apkarian Anesthesia, Surgery, Recipient...
Chronic pain remains poorly understood; yet it is associated with the reorganization of nervous system. Here, we demonstrate that a unitary global measure functional connectivity, defined as extent degree rank order disruption, kD, identifies chronic state. In contrast, local disruption differentiates between conditions. We used resting-state MRI data to analyze brain connectome at varying scales and densities. three conditions, observe disrupted in proportion individuals' intensity,...
Abstract Osteoarthritis (OA) manifests with chronic pain, motor impairment, and proprioceptive changes. However, the role of brain in disease is largely unknown. Here, we studied networks using mathematical properties graphs a large sample knee hip OA (KOA, n = 91; HOA, 23) patients. We used robust validation strategy by subdividing KOA data into discovery testing groups tested generalizability our findings HOA. Despite global topological being conserved OA, show there network wide pattern...