A5039468560- Pain Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Music Therapy and Health
- Stress Responses and Cortisol
- Musculoskeletal pain and rehabilitation
- Diverse Music Education Insights
- Olfactory and Sensory Function Studies
- Neuroscience and Music Perception
- Sport Psychology and Performance
- Ion Channels and Receptors
- Pharmacological Effects and Assays
- Neuropeptides and Animal Physiology
- Evolutionary Psychology and Human Behavior
- Neuroscience of respiration and sleep
- Urinary Bladder and Prostate Research
- Migraine and Headache Studies
- Pain Management and Placebo Effect
- Death Anxiety and Social Exclusion
- Exercise and Physiological Responses
- Veterinary Pharmacology and Anesthesia
- Spine and Intervertebral Disc Pathology
- Pediatric Pain Management Techniques
- Nicotinic Acetylcholine Receptors Study
- Hypothalamic control of reproductive hormones
McGill University
2005-2023
Northwestern University
2011-2012
Concordia University
2009
Empathy is thought to be unique higher primates, possibly humans alone. We report the modulation of pain sensitivity in mice produced solely by exposure their cagemates, but not strangers, pain. Mice tested dyads and given an identical noxious stimulus displayed increased behaviors with statistically greater co-occurrence, effects dependent on visual observation. When familiar were stimuli different intensities, behavior was influenced neighbor's status bidirectionally. Finally, observation...
The innate immune system is increasingly appreciated to play an important role in the mediation of chronic pain, and one molecule implicated this process Toll-like receptor 4 (TLR4). Here, using pharmacological genetic manipulations, we found that activating TLR4 spinal cord, with agonist lipopolysaccharide (LPS), causes robust mechanical allodynia but only male mice. Spinal LPS had no pain-producing effect female also has a sex-specific inflammatory (complete Freund's adjuvant) neuropathic...
Abstract Music’s universality and its ability to deeply affect emotions suggest an evolutionary origin. Previous investigators have found that naltrexone (NTX), a μ-opioid antagonist, may induce reversible anhedonia, attenuating both positive negative emotions. The neurochemical basis of musical experience is not well-understood, the NTX-induced anhedonia hypothesis has been tested with music. Accordingly, we administered NTX or placebo on two different days in double-blind crossover study,...
No AccessJournal of UrologyAdult Urology1 Jul 2011Brain Functional and Anatomical Changes in Chronic Prostatitis/Chronic Pelvic Pain Syndrome Melissa A. Farmer, Mona L. Chanda, Elle Parks, Marwan N. Baliki, Vania Apkarian, Anthony J. Schaeffer FarmerMelissa Farmer Department Physiology, Feinberg School Medicine, Northwestern University, Chicago, Illinois More articles by this author , ChandaMona Chanda ParksElle Parks BalikiMarwan Baliki ApkarianA. Apkarian Anesthesia, Surgery, Recipient...
Migraine is a highly prevalent, disabling and complex episodic brain disorder whose pathogenesis poorly understood, due in part to the lack of valid animal models. Here we report behavioral evidence hallmark migraine features, photophobia unilateral head pain, transgenic knock-in mice bearing human familial hemiplegic migraine, type 1 (FHM-1) gain-of-function missense mutations (R192Q or S218L) Cacna1a gene encoding CaV2.1 calcium channel α1 subunit. Photophobia was demonstrated using...
The 5% Lidocaine patch is used for treating chronic neuropathic pain conditions such as back (CBP), diabetic neuropathy and complex regional syndrome, but effective in a variable proportion of patients. Our lab has reported that this treatment reduces CBP intensity associated brain activations when tested an open labelled preliminary study. Notably, effectiveness the not been against placebo CBP. In study, was compared with 30 patients randomised double-blind study where 15 received patches...
Amiloride is a nonspecific blocker of acid-sensing ion channels (ASICs) that have been recently implicated in the mediation mechanical and chemical/inflammatory nociception. Preliminary data using transgenic model are suggestive sex differences role ASICs. We report here systemic administration amiloride (10-70 mg/kg ip) produces robust, dose-dependent blockade late/tonic phase nociceptive behavior on mouse formalin test (5%; 20 microl) female but not male mice, completely abolishing known...
Abstract Given the evolutionary importance of social ties for survival, humans are thought to have evolved psychobiological mechanisms monitor and safeguard status their bonds. At psychological level, self-esteem is proposed function as a gauge—‘sociometer’—reflecting one’s belongingness status. biological endogenous opioids appear be an important substrate hedonic signalling needed regulate behaviour. We investigated whether may serve correlate sociometer. administered 50 mg naltrexone (an...