Arn M. J. M. van den Maagdenberg
A5012664216- Migraine and Headache Studies
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Trigeminal Neuralgia and Treatments
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Genetic Neurodegenerative Diseases
- Vestibular and auditory disorders
- Neurological Disorders and Treatments
- Cerebrovascular and genetic disorders
- Sympathectomy and Hyperhidrosis Treatments
- Epilepsy research and treatment
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Lipoproteins and Cardiovascular Health
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Psychosomatic Disorders and Their Treatments
- Glycogen Storage Diseases and Myoclonus
- Photoreceptor and optogenetics research
- Metabolomics and Mass Spectrometry Studies
- Pain Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
Leiden University Medical Center
2016-2025
Leiden University
2015-2024
Institute of Psychology, Chinese Academy of Sciences
2023
Massachusetts General Hospital
2009-2020
Harvard University
2009-2020
University of Oslo
2020
Oslo University Hospital
2020
Amsterdam Neuroscience
2017-2019
Institute of Human Genetics
2002-2019
Vrije Universiteit Amsterdam
2019
Type I interferons (IFNs) are essential mediators of antiviral responses. These cytokines have been implicated in the pathogenesis autoimmunity, most notably systemic lupus erythematosus (SLE), diabetes mellitus, and dermatomyositis, as well monogenic type interferonopathies. Despite a fundamental role health disease, direct quantification IFNs has challenging. Using single-molecule array (Simoa) digital ELISA technology, we recorded attomolar concentrations IFNα healthy donors, viral...
Abstract Familial hemiplegic migraine (FHM) is a rare, severe, autosomal dominant subtype of with aura. Up to 75% FHM families have mutation in the P/Q‐type calcium channel Ca v 2.1 subunit CACNA1A gene on chromosome 19p13. Some mutations also may cause epilepsy. Here, we describe novel missense ATP1A2 Na + ,K ‐ATPase pump 1q23 two FHM. The M731T was found family pure R689Q identified which and benign familial infantile convulsions partially cosegregate. In this family, all available...
Trivial head trauma may be complicated by severe, sometimes even fatal, cerebral edema and coma occurring after a lucid interval (“delayed edema”). Attacks of familial hemiplegic migraine (FHM) can triggered minor are accompanied coma. Mutations in the CACNA1A calcium channel subunit gene on chromosome 19 associated with wide spectrum mutation-specific episodic chronic neurological disorders, including FHM or without We investigated role three subjects delayed edema. Two originated from...
Familial hemiplegic migraine type 1 (FHM1) is an autosomal dominant subtype of with aura that associated hemiparesis. As other types migraine, it affects women more frequently than men. FHM1 caused by mutations in the CACNA1A gene, which encodes alpha1A subunit Cav2.1 channels; R192Q mutation causes a mild form FHM1, whereas S218L severe, often lethal phenotype. Spreading depression (SD), slowly propagating neuronal and glial cell depolarization leads to activity, most likely cause aura....
Apolipoprotein E3-Leiden (APOE*3-Leiden) transgenic mice have been used to study the effect of different cholesterol-containing diets on remnant lipoprotein levels and composition possible concurrent development atherosclerotic plaques. On high fat/cholesterol (HFC) diet, expressing lines 2 181 developed severe hypercholesterolemia (up 40 60 mmol/liter, respectively), whereas triglyceride remained almost normal when compared with regular mouse diet. The addition cholate increased...