A5027891042- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Child Abuse and Trauma
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Mind wandering and attention
- Neuroendocrine regulation and behavior
- Alcoholism and Thiamine Deficiency
- Prenatal Substance Exposure Effects
- Posttraumatic Stress Disorder Research
- Substance Abuse Treatment and Outcomes
- Neural and Behavioral Psychology Studies
- Anesthesia and Neurotoxicity Research
University of North Carolina at Chapel Hill
2019-2025
Massachusetts General Hospital
2018-2019
Harvard University
2019
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental characterized by hyperactivity/impulsivity and inattentiveness. Efforts toward the development of biologically based diagnostic test have identified differences in EEG power spectrum; most consistently reported an increased ratio theta to beta during resting state those with disorder, compared controls. Current approaches calculate theta/beta using fixed frequency bands, but observed may be confounded other...
Abstract Background Disruptions in neural circuits underlying emotion regulation (ER) may be a mechanism linking child maltreatment with psychopathology. We examined the associations of responses during passive viewing negative emotional stimuli and attempts to modulate responses. investigated whether influence on activation ER differed across development alterations brain function mediated association between latent general psychopathology (‘ p ’) factor. Methods Youth aged 8–16 years ( n =...
Electrical neuromodulation via implanted electrodes is used in treating numerous neurological disorders, yet our knowledge of how different brain regions respond to varying stimulation parameters sparse.We hypothesized that the neural response electrical both region-specific and non-linearly related amplitude frequency.We examined evoked responses following 400 ms trains 10-400 Hz ranging from 0.1 10 mA. We stimulated cingulate cortex (dorsal anterior rostral cingulate) subcortical (nucleus...
Objective: Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent and impairing neurodevelopmental disorder. While early childhood crucial time for intervention, it characterized by instability of ADHD diagnosis. Neural correlates have potential to improve diagnostic accuracy; however, minimal research has focused on childhood. Research indicates that disrupted neural connectivity associated with in older children. Here, we explore network as correlate diagnosis...
Abstract Background Hazardous use of alcohol is associated with cognitive‐behavioral impairments and accelerated aging. To date, however, brain aging has not been tested as a mediating factor between task‐based behavioral deficits, such inflexibility. Here, we evaluated hazardous predictor machine learning‐derived if this measure accounted for the relationship flexibility. Methods In secondary analysis, applied brainageR , learning algorithm, to anatomical T1‐weighted magnetic resonance...
Objective. Deep brain stimulation (DBS) is a valuable tool for ameliorating drug resistant pathologies such as movement disorders and epilepsy. DBS also being considered complex neuro-psychiatric disorders, which are characterized by high variability in symptoms slow responses that hinder setting optimization. The objective of this work was to develop an silico platform examine the effects electrical regions neighboring stimulated region. Approach. We used Jansen–Rit neural mass model single...
Abstract Background Fear learning is a core component of conceptual models how adverse experiences may influence psychopathology. Specifically, existing theories posit that childhood involving trauma are associated with altered fear processes, while deprivation not. Several studies have found acquisition in youth exposed to trauma, but not deprivation, although the specific patterns varied across studies. The present study utilizes longitudinal sample children variability adversity examine...