A5023672680- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Smoking Behavior and Cessation
- Genetic Mapping and Diversity in Plants and Animals
- Genomic variations and chromosomal abnormalities
- Bioinformatics and Genomic Networks
- Estrogen and related hormone effects
- Machine Learning in Bioinformatics
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Autism Spectrum Disorder Research
- Genetics, Bioinformatics, and Biomedical Research
- Nutrition, Genetics, and Disease
- Stress Responses and Cortisol
- Media Influence and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Behavioral Health and Interventions
- Genomics and Chromatin Dynamics
- Gene expression and cancer classification
- Neuroscience and Neuropharmacology Research
University of North Carolina at Chapel Hill
2019-2022
Center for Neurosciences
2019
Abstract Cigarette smoking is the leading cause of preventable morbidity and mortality. Genetic variation contributes to initiation, regular smoking, nicotine dependence, cessation. We present a Fagerström Test for Nicotine Dependence (FTND)-based genome-wide association study in 58,000 European or African ancestry smokers. observe five significant loci, including previously unreported loci MAGI2/GNAI1 (rs2714700) TENM2 (rs1862416), extend reported other traits dependence. Using heaviness...
Abstract Hi-C coupled multimarker analysis of genomic annotation (H-MAGMA) was initially developed to advance MAGMA by assigning non-coding SNPs their cognate genes based on threedimensional chromatin architecture. Yurko and colleagues raised concerns that the SNP-wise mean gene-analysis model may allow inflation in type I errors. Accordingly, we updated found version (MAGMA v.1.08) effectively controls for error rate inflation. Intrigued this result, H-MAGMA also implementing v.1.08. As...
Abstract Background The US electronic cigarette (ECIG) market and use behavior continues to rise, warranting investigation of ECIG advertisement (ad) content within media channels frequented by youth including internet television (TV). In order inform potential policy regulations, this analysis sought assess the prevalence youth-appealing spend characteristics among video ads. Methods Between 2015 2016, 46 ads were identified using an ad-tracking firm coded Content Appealing Youth (CAY)...
Abstract Cigarette smoking is the leading cause of preventable morbidity and mortality. Knowledge evolving on genetics underlying initiation, regular smoking, nicotine dependence (ND), cessation. We performed a genome-wide association study using Fagerström Test for ND (FTND) in 58,000 smokers European or African ancestry. Five significant loci, including two novel loci MAGI2/GNAI1 (rs2714700) TENM2 (rs1862416) were identified, reported other traits extended to ND. Using heaviness index...
Abstract Despite being clinically distinguishable, many neuropsychiatric disorders display a remarked level of genetic correlation and overlapping symptoms. Deciphering neurobiological mechanisms underlying potential shared etiology is challenging because (1) most common risk variants reside in the non-coding region genome, (2) genome-wide framework required to compare association studies (GWAS) having different power. To address these challenges, we developed platform, Hi-C coupled MAGMA (...
Abstract Cigarette smoking and alcohol use are among the most prevalent substances used worldwide account for a substantial proportion of preventable morbidity mortality, underscoring public health significance understanding their etiology. Genome-wide association studies (GWAS) have successfully identified genetic variants associated with cigarette traits. However, vast majority risk reside in non-coding regions genome, target genes neurobiological mechanisms unknown. Chromosomal...