Bupropion has been used in the treatment of patients with substance dependence based on its weak inhibition dopamine and norepinephrine reuptake. We hypothesized that 6 weeks bupropion sustained release (SR) would decrease craving for Internet game play as well video cue-induced brain activity addiction (IAG). Eleven subjects who met criteria IAG, playing StarCraft (>30 hr/week), eight healthy comparison (HC) had experience (<3 days/week <1 hr/day). At baseline at end SR treatment, response...

As one of the problematic behaviors in patients with major depressive disorder (MDD), excessive online game play (EOP) has been reported a number recent studies. Bupropion evaluated as potential treatment for MDD and substance dependence. We hypothesized that bupropion would reduce severity EOP well symptoms. Fifty male subjects comorbid were randomly assigned to + education internet use (EDU) or placebo EDU groups. The current study consisted 12-week, prospective, randomized, double-blind...

Brain responses, particularly within the orbitofrontal and cingulate cortices, to Internet video-game cues in college students are similar those observed patients with substance dependence response substance-related cues. In this study, we report changes brain activity between baseline following 6 weeks of play. We hypothesized that subjects high levels self-reported craving for play would be associated increased prefrontal cortex, anterior cortex. Twenty-one healthy university were...

Objective There is a high prevalence of problematic online gaming in adolescents with attention deficit hyperactivity disorder (ADHD). In the current study, we compared effectiveness atomoxetine (ATM) and methylphenidate (MPH) on ADHD. Methods We recruited 86 diagnosed ADHD together Internet disorder. These participants were divided into two treatment groups: 44 treated MPH for 12 weeks, 42 ATM weeks. Results During 3-month study period, group showed greater improvement Korean rating scale...

Comparison of QEEG Findings between Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) without Comorbidity and ADHD Comorbid Internet Gaming DisorderInternet gaming disorder (IGD) is often comorbid attention deficit hyperactivity (ADHD).In this study, we compared the neurobiological differences IGD (ADHD+IGD group) comorbidity (ADHD-only by analyzing quantitative electroencephalogram (QEEG) findings.We recruited 16 male ADHD+IGD, 15 ADHD-only adolescent patients, healthy...

Comparison of Electroencephalography (EEG) Coherence between Major Depressive Disorder (MDD) without Comorbidity and MDD Comorbid with Internet Gaming DisorderInternet gaming disorder (IGD) has many comorbid psychiatric problems including major depressive (MDD).In the present study, we compared neurobiological differences comorbidity (MDD-only) IGD (MDD+IGD) by analyzing quantitative electroencephalogram (QEEG) findings.We recruited 14 male MDD+IGD (mean age, 20.0 ± 5.9 years) 15 MDD-only...

ABSTRACT Objective The aim of the study was to evaluate whether individuals with somatic symptom disorder (SSD) display increased resting-state functional connectivity (FC) within and between sensorimotor network (SMN), default mode (DMN), salience network, dorsal attention (DAN). Methods Eighteen patients SSD 20 age- sex-matched healthy control participants underwent magnetic resonance imaging. We used a seed-based correlation approach for four brain networks. Results Patients had higher...

Although there is some evidence supporting the existence of an association between prenatal maternal or postnatal child’s urine phthalate metabolite concentrations and poor attentional performances, interaction levels genetic variation for neuropsychological deficit attention-deficit hyperactivity disorder (ADHD) has not been examined. The aim this study was to determine whether metabolites in are associated with performance children ADHD, such affected by genotype-phthalate interaction. A...

The effective treatment of depression has been reported to reduce the severity alcohol use, potentially reflecting improvements in common brain reward circuits. We hypothesized that augmentation therapy escitalopram with aripiprazole would improve depressive symptoms as well craving for and cue-induced activity patients co-morbid dependence major disorder, compared alone. Thirty-five subjects disorder were recruited randomly assigned into 17 + 18 only groups. At baseline following six weeks...

Objective Many studies have reported that Taekwondo training could improve body perception, control and brain activity, as assessed with an electroencephalogram. This study aimed to assess intelligence connectivity in children compared without training. Methods Fifteen (TKD) 13 age- sex-matched who had no previous experience of (controls) were recruited. Body intelligence, clinical characteristics all the Intelligence Scale (BIS), self-report, resting state functional magnetic resonance...

Background and aims: Several studies have suggested that addictive disorders including substance abuse pathologic gambling might be associated with dysfunction on working memory prefrontal activity. We hypothesized excessive online game playing is deficits in cortex function recovery from improve cortical activation response to stimulation. Methods: Thirteen adolescents (AEOP) ten healthy (HC) agreed participate this study. The severity of play time were evaluated for a baseline measurement...

High homocysteine serum level has been regarded as one of the important factors that influence development schizophrenia. Genetic variations methylenetetrahydrofolate reductase, which is a main enzyme reducing level, are reported in schizophrenic patients. We measured homocysteine/folate and reductase C677T/A1298C gene polymorphism 235 patients with Plasma levels were higher folate lower than comparison subjects. Variations C677T more frequent Patients 677TT genotype showed CC CT genotypes....

Somatic symptom disorder (SSD) often co-occurs with major depressive (MDD). Both conditions share common psychobiological and biobehavioral characteristics, but little is known about differential patterns in brain function. In this study, we compared resting-state functional connectivity between SSD MDD using quantitative electroencephalography.Fifteen patients (SSD group), 15 (MDD healthy volunteers (healthy control [HC] group) participated study. Participants were assessed...

Abstract Background This study aimed to develop a simple and one-off olfactory screening test, the sniffing bead system, for general clinical use in older adults . Methods In this cross-sectional study, geriatric subjects (aged &gt; 50 years) who underwent neurocognitive function tests were included. Overall, 137 enrolled, was conducted at Chung-Ang University, Seoul, Korea. Olfactory measured by obtaining scores of system using 2-phenylethyl alcohol, n-butanol, YSK test. Time taken each...

Evidence supporting a link between postnatal environmental tobacco smoke (ETS) exposure and cognitive problems among children is mounting, but inconsistent.We examined the relationship ETS exposure, measured using urine cotinine, IQ scores in Korean school-aged children.The participants were 996 8-11 years of age recruited from five administrative regions South Korea. We performed cross-sectional analysis urinary cotinine concentrations obtained abbreviated form version Wechsler Intelligence...

Objective Repetitive transcranial magnetic stimulation (rTMS) was approved by the Food and Drug Administration to alleviate symptoms of treatment-resistant depression. This study aimed evaluate effectiveness rTMS treatment on alleviating occupational stress evaluating clinical quantitative electroencephalography (QEEG). Methods Twenty-four health care workers were randomized receive 12 sessions active or sham delivered left dorsolateral prefrontal cortex (DLPFC). Each session consisted 32...