A5073757884- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Forensic Toxicology and Drug Analysis
- Treatment of Major Depression
- RNA Research and Splicing
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Diet, Metabolism, and Disease
- Berberine and alkaloids research
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Neuropeptides and Animal Physiology
- Circadian rhythm and melatonin
- Hereditary Neurological Disorders
- Polyamine Metabolism and Applications
- Silymarin and Mushroom Poisoning
- Medicinal Plants and Bioactive Compounds
- Drug Transport and Resistance Mechanisms
University of New Mexico
2024-2025
University of Wisconsin–Madison
2022-2023
University of Massachusetts Lowell
2022
The University of Texas at Dallas
2018-2022
Sahmyook University
2011-2021
Loma Linda University
2017
Opioids are among the most widely prescribed treatments for pain; however, prolonged use leads to adverse effects, including reduced analgesic efficacy (tolerance) and paradoxically heightened pain sensitivity (opioid-induced hyperalgesia, OIH). Neurons that detect noxious stimuli within dorsal root ganglion (DRG), referred as nociceptors, mediate both beneficial maladaptive effects of opioids. Although post-transcriptional regulation is critical DRG function, role circular RNAs (circRNAs),...
Abstract Sensory neurons are integral to the genesis and maintenance of neuropathic pain. The molecular mechanisms that mediate long-lived changes in their excitability unclear. Here, we leverage functional genomics approaches survey RNA abundance translation dorsal root ganglion from a mouse model paclitaxel-induced We focus specifically on females as paclitaxel is first-line therapy for breast cancer. sequencing data indicate substantially more occur at level (n = 404) than transcription...
Nicotine addiction is a worldwide problem. However, previous studies characterizing the rewarding and reinforcing effects of nicotine in animal models have reported inconsistent findings. It was observed that addictive are variable on different factors (e.g. route, dose, age). Here, we evaluated routes administration, across wide dose range, age groups. Two most widely used drug were employed: conditioned place preference (CPP) self-administration (SA) tests. CPP [intraperitoneal (i.p.)...
Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered species. Studies on its chemical constituents have shown that VG remarkably rich in saponins, particularly ocotillol saponins. However, the psychopharmacological effects of not been characterized. Thus, present study we screened activities mice. extract (VGE) was orally administered to mice at various dosages evaluate psychomotor (open-field and rota-rod tests), sedative–hypnotic (pentobarbital-induced...
Injury responses require communication between different cell types in the skin. Sensory neurons contribute to inflammation and can secrete signaling molecules that affect non-neuronal cells. Despite pervasive role of translational regulation nociception, contribution activity-dependent protein synthesis is not well understood. To address this problem, we examined landscape nascent translation murine dorsal root ganglion (DRG) treated with inflammatory mediators using ribosome profiling. We...
Milk has long been known and used to promote sleep. The sleep-promoting effect of milk attributed its psychological associations (i.e., the memory a mother giving at bedtime) rich store constituents (e.g., tryptophan). Studies have shown that harvested night (Night milk) contains exceptionally high amounts tryptophan melatonin. In present study, we evaluated psychopharmacological properties Night milk, particularly probable sleep-promoting/enhancing, anxiolytic effects. was orally...
Abstract Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous exogenous factors. Per2 , circadian gene, plays role in drug addiction. Previous studies using ‐knockout mice have shown for cocaine, morphine alcohol In the present study, we investigated of methamphetamine (METH) Per2‐ overexpression knockout mice. We observed locomotor sensitization responses to METH administration, rewarding effects conditioned place preference test....
The emergence and use of synthetic cannabinoids have greatly increased in recent years. These substances are easily dispensed over the internet on streets. Some were shown to abuse liability subsequently regulated by authorities. However, there compounds that still not probably due lack studies. In present study, we assessed three cannabinoids, namely JWH-030, JWH-175, JWH-176. these drugs was evaluated two most widely used animal models for assessing potential drugs, conditioned place...
Abstract Adolescence is a critical period for cigarette smoking. Studies have shown that adolescent smokers are more likely to become addicted, less quit, and prone relapse. In the present study, we examined affective symptoms experienced by adolescents during withdrawal from smoke exposure. Towards this goal, male rats were repeatedly exposed smoke, through an automated smoking machine, 14 days. Then, exposure was discontinued induce spontaneous withdrawal. During period, anxiety‐like...