A5026907838- Healthcare and Venom Research
- Food Quality and Safety Studies
- Pharmacological Effects of Natural Compounds
- Nanoplatforms for cancer theranostics
- Ginseng Biological Effects and Applications
- Health and Wellbeing Research
- Nutrition, Health and Food Behavior
- Phytoestrogen effects and research
- Photodynamic Therapy Research Studies
- Hypothalamic control of reproductive hormones
- Bioactive Compounds and Antitumor Agents
- Menstrual Health and Disorders
- Chemotherapy-induced organ toxicity mitigation
- Traditional Chinese Medicine Studies
- Natural product bioactivities and synthesis
- Medicinal Plant Pharmacodynamics Research
- Estrogen and related hormone effects
- Ginger and Zingiberaceae research
- Lipid metabolism and disorders
- Menopause: Health Impacts and Treatments
- Nicotinic Acetylcholine Receptors Study
- Ovarian function and disorders
- Meat and Animal Product Quality
- Memory and Neural Mechanisms
- Growth Hormone and Insulin-like Growth Factors
Daejeon University
2011-2025
Pusan National University Yangsan Hospital
2017-2025
Hanyang University
2018-2025
Ewha Womans University
2025
Chungnam National University
2024
Korea Institute of Brain Science
2022-2023
Korea Institute of Science and Technology
2022-2023
Kyung Hee University
2012-2022
University of California, Irvine
2022
Korean Association Of Science and Technology Studies
2022
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon that associated with dysbiosis in gut microbiota. Eisenia bicyclis, marine alga, known for its anti-inflammatory, antioxidant, and microbiota-modulating properties. This study explored mechanisms by which 70% ethanol extract E. bicyclis may alleviate UC, through both vitro vivo experiments. LC-MS/MS analysis revealed eckol, 7-phloroeckol, dieckol, phlorofucofuroeckol A, fucofuroeckol as key phenolic compounds present...
Osteoporosis is a highly prevalent public health burden associated with an increased risk of bone fracture, particularly in aging women. Estrogen, important medicinal component for the preventative and therapeutic treatment postmenopausal osteoporosis, induces osteogenesis by activating estrogen receptor signaling pathway upregulating expression osteogenic genes, such as morphogenetic proteins (BMPs). The epigenetic regulation estrogen-mediated osteogenesis, however, still unclear. In this...
// Jie Zheng 1 , Hye Lim Lee Young Wan Ham 2 Ho Sueb Song 3 Min Jong 4 Jin Tae Hong College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, 361-763, South Korea Department Chemistry, Utah Valley Orem, UT 84508, USA Oriental Medicine, Kyungwon Sujeong-gu, Seongnam, Gyeonggii 461-701, Obstetrics Gynecology, Daejeon St. Mary's Hospital, The Catholic University Korea, Jung-gu, 301-723, Correspondence to: Hong, e-mail: jinthong@chungbuk.ac.kr Song,...
Mesenchymal stem cells (MSCs) are a promising tool in regenerative medicine due to their capacity differentiate into multiple lineages. In addition MSCs isolated from bone marrow (BMSCs), adult craniofacial tissues including dental pulp (DPs) using various cell surface markers. However, there has been lack of consensus on set makers that reproducibly effective at isolating putative multipotent mesenchymal (DMSCs). this study, we used different combinations markers (CD51/CD140α, CD271, and...
A popular approach for the study of estrogen receptor α inhibition is to investigate protein-protein interaction between (ER) and coactivator surface. In our study, we investigated phytochemicals from Rubus coreanus that were able disrupt ERα with an antagonist. The E-screen assay molecular docking analysis performed evaluate effects estrogenic activity R. extract its constituents on MCF-7 human breast cancer cell line. At 100μ g/mL, significantly stimulated proliferation (574.57 ± 8.56%)....
Abstract Objectives Maintaining glucose homoeostasis is essential for the survival of cells. Despite various health benefits Korean thistle (Cirsium japonicum var. maackii), their effects on pancreatic β-cell apoptosis in type 1 diabetes mellitus and underlying mechanisms remain unclear, experimentally investigated this study. Methods The C. maackii its active component cirsimaritin against streptozotocin (STZ)-induced cytotoxicity were assessed INS-1 By Western blotting analysis, protein...
The aim of the present study was to evaluate potential protective effects six ginsenosides (Rb1, Rb2, Rc, Rd, Rg1, and Rg3) isolated from Panax ginseng against tacrolimus (FK506)-induced apoptosis in renal proximal tubular LLC-PK1 cells. cells were treated with FK506 ginsenosides, cell viability measured. Protein expressions mitogen-activated protein kinases, caspase-3, kidney injury molecule-1 (KIM-1) evaluated by Western blotting analyses. number apoptotic measured using an image-based...
OBJECTIVESLow handgrip strength in children and adolescents might be associated with the risk of metabolic syndrome (MetS) insulin resistance. This study prospectively evaluated association between (HGS) childhood MetS adolescence. METHODSBased on data from Ewha Birth Growth Study, this analyzed at ages 7 to 9 indices 13 15. In total, 219 participants were analyzed. The was using continuous score (cMetS), resistance assessed fasting blood homeostasis model assessment (HOMA-IR). Relative...
Background/Objectives: This study evaluated the effects of a novel Astragalus extract (Keyfobell powder [KFB]) composed membranaceus, red ginseng (Panax C. A. Meyer), and Cervi Parvum Cornu as potential growth hormone (GH) alternative. The primary focus was placed on its impact longitudinal bone through upregulation circulatory insulin-like factor (IGF)-1. Methods: We performed in vitro vivo experiments using hypothalamic cell line Sprague–Dawley (SD) rats. Quantitative RT-PCR to determine...
ABSTRACT The evaluation of ESG ratings by rating agencies is time‐consuming and requires the participation numerous human specialists. In this paper, we propose a method for creating proxies scores collecting corporate news publicly available ESG‐related data using crawling techniques deep learning‐based classification technology while minimizing involvement. To validate effectiveness proposed approach, suggest three hypotheses. Two them are related to connection between open‐source...
Ginsenosides are active components of Panax ginseng that exert various health benefits including kidney protection effect. The medicinal activity ginsenosides can be enhanced by modulating their stereospecificity heat processing. Rk2 and Rh3 represent positional isomers the double bond at C-20(21) or C-20(22). present study investigated kidney-protective effects against cisplatin, a platinum based anticancer drug, induced apoptotic damage in renal proximal LLC-PK1 cells. As result,...
PARK2 encodes for the E3 ubiquitin ligase parkin and is implicated in development of Parkinson's disease (PD).Although neuroprotective role well known, mechanism PARK2's function neural stem differentiation has not yet been thoroughly studied.Co-expressions network analysis showed that synaptosomal-associated protein 25 (SNAP-25) brain-derived neurotrophic factor (BDNF) were positively correlated with parkin, but negatively p21 human patient brain.We investigated a link between proteasomal...
The purpose of this study was to evaluate the anticancer efficacy cetuximab combined with cisplatin (combination treatment) on colon cancer growth, as well its underlying action mechanism. Combination treatment synergistically potentiated effect cell growth inhibition and apoptosis induction in HCT116 SW480 cells. further suppressed expression activated form epidermal factor receptor (EGFR) MAP kinase (p-ERK p-p38) also significantly inhibited activity activator protein-1 (AP-1) nuclear...
Shiunko ointment is composed of five ingredients including Lithospermi Radix (LR), Angelicae Gigantis Radix, sesame seed oil, beeswax, and swine oil. It externally applied as a treatment for wide range skin conditions such eczema, psoriasis, hair loss, burns, topical wounds, atopic dermatitis. Deoxyshikonin the major angiogenic compound extracted from LR. In this study, we investigated efficacy LR extract deoxyshikonin on impaired wound healing in streptozotocin (STZ)-induced diabetic mice....
We synthesized dextran-chlorin e6 conjugates having disulfide linkage for specific targeting of colonic region and cancer cells. Reductive end group dextran was treated with sodium borocyanohydride conjugated cystamine. Cystamine carboxylic acid chlorin (DEX6ss). DEX6ss were formed as spherical nanoparticles small sizes less than 100 nm. Chlorin (Ce6) specifically released from in the presence dextranase or glutathione (GSH), indicating that have responsiveness against redox-environment. In...