M. Alejandra Infante
A5086486265- Prenatal Substance Exposure Effects
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Attention Deficit Hyperactivity Disorder
- Birth, Development, and Health
- Cannabis and Cannabinoid Research
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Folate and B Vitamins Research
- Substance Abuse Treatment and Outcomes
- Memory and Neural Mechanisms
- Sleep and related disorders
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience of respiration and sleep
- Ovarian function and disorders
- Homelessness and Social Issues
- Traumatic Brain Injury Research
- Liver Disease and Transplantation
- Neonatal Health and Biochemistry
- Genetics and Neurodevelopmental Disorders
- Mental Health Research Topics
- Hypothalamic control of reproductive hormones
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cognitive Abilities and Testing
University of California, San Diego
2011-2022
San Diego State University
2009-2020
VA San Diego Healthcare System
2010
This study prospectively examines the influence of alcohol on neuropsychological functioning in boys and girls characterized prior to initiating drinking (N = 76, ages 12-14). Adolescents who transitioned into heavy (n 25; 11 girls, 14 boys) or moderate 11; 2 9 were compared with matched controls remained nonusers throughout approximately 3-year follow-up period 40; 16 24 boys). For more past year days predicted a greater reduction visuospatial task performance from baseline follow-up, above...
Aim To examine individual variability between perceived physical features and hormones of pubertal maturation in 9–10-year-old children as a function sociodemographic characteristics. Methods Cross-sectional metrics puberty were utilized from the baseline assessment Adolescent Brain Cognitive Development (ABCD) Study—a multi-site sample 9–10 year-olds (n = 11,875)—and included via development scale (PDS) child salivary hormone levels (dehydroepiandrosterone testosterone all, estradiol...
The effect of adolescent marijuana use on brain development remains unclear despite relaxing legal restrictions, decreased perceived harm, and increasing rates among youth. aim this 3-year prospective study was to evaluate the long-term neurocognitive effects use.Adolescent users with concomitant alcohol (MJ + ALC, n = 49) control teens limited substance histories (CON, 59) were given neuropsychological assessments at project baseline, when they ages 16-19. They then reassessed 18 36 months...
Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to requiring urgent medical intervention. In the case of brain magnetic resonance (MRI), reliable data about prevalence significance IFs in general population limited, making it difficult anticipate, communicate, manage these findings.To determine overall MRI nonclinical pediatric as well rates specific for which clinical referral is recommended.This cohort study was...
The age- and time-dependent effects of binge drinking on adolescent brain development have not been well characterized even though is a health crisis among adolescents. impact gray matter volume (GMV) was examined using 5 waves longitudinal data from the National Consortium Alcohol NeuroDevelopment in Adolescence study. Binge drinkers (n = 166) were compared with non-binge 82 after matching potential confounders). Number episodes past year linked to decreased GMVs bilateral Desikan-Killiany...
Abstract The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects environmental influences on behavioral and brain development in adolescents. ABCD a collaborative effort, including Coordinating Center, 21 data acquisition sites across United States, Data Analysis Informatics Center (DAIC). main objective to recruit assess over eleven thousand 9-10-year-olds follow them course 10 years characterize normative cognitive development, many factors...
Abstract Objectives: Alcohol and cannabis remain the substances most widely used by adolescents. Better understanding of dynamic relationship between trajectories substance use in relation to neuropsychological functioning is needed. The aim this study was examine different impacts within- between-person changes alcohol on over multiple time points. Methods: Hierarchical linear modeling examined effects course 14 years a sample 175 adolescents (aged 12–15 at baseline). Results: Time-specific...
Objective: Changes in gray matter volume and thickness are associated with adolescent alcohol cannabis use, but the impact of these substances on surface area remains unclear. The present study expands previous findings to examine before after use initiation. Method: Scans for 69 demographically similar youth were obtained at baseline (ages 12–14 years; substance use) 6-year follow-up 17–21 years). Participants classified into three groups based use: initiators (ALC, n = 23), (ALC+CU,...
To validate an automated cerebellar segmentation method based on active shape and appearance modeling then segment the cerebellum images acquired from adolescents with histories of prenatal alcohol exposure (PAE) non-exposed controls (NC). Automated segmentations total cerebellum, right left hemispheres, three vermal lobes (anterior, lobules I–V; superior posterior, VI–VII; inferior VIII–X) were compared to expert manual labelings 20 subjects, studied twice, that not used for model training....
The considerable comorbidity of posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD) poses a greater public health burden than either condition alone. Although there is substantial body evidence linking the direct neurotoxic effect heavy drinking to gray matter (GM) deficits, as well growing literature supporting strong association between PTSD GM alterations, scant research interrogating interaction two disorders. In order generate data-driven, specific hypotheses regarding...
Background Youth whose parents have alcohol use disorder (AUD) are at higher risk for earlier initiation and greater magnitude of use, a likelihood developing an AUD than their peers without parental history AUD. This increased may be partly attributable to altered development inhibitory control related neural circuitry. study examined activation during motor response inhibition Stop Signal Task (SST) in substance‐naïve youth aged 9 10 years with family Methods Baseline cross‐sectional...
In children with prenatal alcohol exposure, spatial working memory is affected and brain regions important for performance exhibit atypical neurodevelopment. We therefore hypothesized that exposure may also have development of ability.We examined the relation between age using a cross-sectional developmental trajectory approach in youth without histories heavy exposure. The Cambridge Neuropsychological Test Automated Battery Spatial Working Memory subtest was administered to 5.0 16.9 years...
Abstract Objective: Verbal memory deficits are linked to cannabis use. However, self-reported episodic use does not allow for assessment of variance from other factors (e.g., potency, route consumption) that important assessing brain-behavior relationships. Further, co-occurring nicotine may moderate the influence on cognition. Here we utilized objective urinary measurements assess relationship between metabolites cannabis, 11-nor-9-carboxy-∆9-tetrahydrocannabinol (THCCOOH), and (cotinine)...
Background Acute alcohol consumption is associated with temporarily increased regional cerebral blood flow (CBF). The extent of this increase appears to be moderated by individual differences in the level response (LR) alcohol's subjective effects. low LR phenotype a known risk factor for development problems. This study investigates how relates relationship between alcohol‐related changes CBF and problems 5 years later. Methods Young adults (ages 18 25) were selected based on their...