Alan N. Simmons

ORCID: 0000-0003-3963-2112
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About
Contact & Profiles
Research Areas
  • Functional Brain Connectivity Studies
  • Neural and Behavioral Psychology Studies
  • Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Psychosomatic Disorders and Their Treatments
  • Traumatic Brain Injury Research
  • Posttraumatic Stress Disorder Research
  • Mental Health Research Topics
  • Eating Disorders and Behaviors
  • Obsessive-Compulsive Spectrum Disorders
  • Memory and Neural Mechanisms
  • Stress Responses and Cortisol
  • Child Abuse and Trauma
  • Child and Adolescent Psychosocial and Emotional Development
  • Advanced Neuroimaging Techniques and Applications
  • Pain Management and Placebo Effect
  • Heart Rate Variability and Autonomic Control
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Pain Mechanisms and Treatments
  • Anesthesia and Neurotoxicity Research
  • Attention Deficit Hyperactivity Disorder
  • Neural dynamics and brain function
  • Cardiac Arrest and Resuscitation
  • Musculoskeletal pain and rehabilitation
  • EEG and Brain-Computer Interfaces
  • Fibromyalgia and Chronic Fatigue Syndrome Research

University of California, San Diego
2016-2025

VA San Diego Healthcare System
2016-2025

Veterans Health Administration
2016-2024

United States Department of Veterans Affairs
2023

New York State Psychiatric Institute
2023

UNSW Sydney
2023

San Diego State University
2022

San Francisco VA Medical Center
2017-2022

United States University
2022

Rush University Medical Center
2021

Increased amygdala reactivity during processing of certain types emotional stimuli (e.g., fear, anger) has been observed in patients with anxiety disorders such as social phobia and posttraumatic stress disorder (PTSD). It is uncertain whether this heightened specific to treatment-seeking or a general feature individuals increased anxiety-related temperamental traits.Thirty-two physically healthy subjects 18-21 years old were recruited from large pool college students. Of these, 16 chosen on...

10.1176/ajp.2007.164.2.318 article EN American Journal of Psychiatry 2007-02-01

Marines who had first received Mindfulness-Based Mind Fitness Training, which can affect brain structures integral to the body’s response stress, experienced quicker heart rate and breathing recovery, improved sleep quality, lower levels of neuropeptide Y after stressful combat training than a comparison group without intervention.

10.1176/appi.ajp.2014.13040502 article EN American Journal of Psychiatry 2014-05-16

Well-established in the field of bioelectronic medicine, Spinal Cord Stimulation (SCS) offers an implantable, non-pharmacologic treatment for patients with intractable chronic pain conditions. Chronic is a widely heterogenous syndrome regard to both pathophysiology and resultant phenotype. Despite advances our understanding SCS-mediated antinociception, there still exists limited evidence clarifying pathways recruited when patterned electric pulses are applied epidural space. The rapid...

10.1186/s42234-019-0023-1 article EN cc-by Bioelectronic Medicine 2019-06-28

<h3>Background</h3> Functional neuroimaging may elucidate the pathophysiologic features of anxiety disorders and site action anxiolytic drugs. A large body evidence suggests that amygdala associated limbic structures play a critical role in expression be treatment targets for <h3>Objective</h3> To determine whether lorazepam dose-dependently attenuates blood oxygenation level–dependent functional magnetic resonance imaging (BOLD fMRI) activation during an emotion face assessment task....

10.1001/archpsyc.62.3.282 article EN Archives of General Psychiatry 2005-03-01

<h3>Context</h3> Chronic pain and depression are highly comorbid conditions, yet little is known about the neurobiological basis of processing in major depressive disorder (MDD). <h3>Objective</h3> To examine neural substrates underlying anticipation heat a group unmedicated young adults with current MDD. <h3>Design</h3> Functional magnetic resonance neuroimaging data were collected during an event-related factorial experimental paradigm. Painful nonpainful stimuli applied to left volar...

10.1001/archpsyc.65.11.1275 article EN Archives of General Psychiatry 2008-11-03

Liberals and conservatives exhibit different cognitive styles converging lines of evidence suggest that biology influences differences in their political attitudes beliefs. In particular, a recent study young adults suggests liberals have significantly brain structure, with showing increased gray matter volume the anterior cingulate cortex, amygdala. Here, we explore function by matching publicly-available voter records to 82 subjects who performed risk-taking task during functional imaging....

10.1371/journal.pone.0052970 article EN cc-by PLoS ONE 2013-02-13

Understanding the neural substrates of anticipation is required for a comprehensive model ways in which anxiety influences information processing. While it apparent that insula and medial frontal cortex are involved processing physical (i.e., painful) stimuli, their role aversive affective stimuli has yet to be determined. Twenty-eight healthy non-phobic volunteers observed images (spiders snakes) were preceded by an auditory signal. The insula, dorsolateral prefrontal cortex,...

10.1097/00001756-200410050-00024 article EN Neuroreport 2004-09-15

<h3>Context</h3>Posttraumatic stress disorder (PTSD) has been associated with executive or attentional dysfunction and problems in emotion processing. However, it is unclear whether these two domains of are related to common distinct neurophysiological substrates.<h3>Objective</h3>To examine the hypothesis that greater neuropsychological impairment PTSD relates disruption prefrontal-subcortical networks during emotional anticipation.<h3>Design</h3>Case-control, cross-sectional...

10.1001/archgenpsychiatry.2011.1539 article EN Archives of General Psychiatry 2012-04-01

Recent studies suggest that altered function of higher-order appetitive neural circuitry may contribute to restricted eating in anorexia nervosa and overeating bulimia nervosa. This study used sweet tastes interrogate gustatory neurocircuitry involving the anterior insula related regions modulate sensory-interoceptive-reward signals response palatable foods.Participants who had recovered from were studied avoid confounding effects nutritional state. Functional MRI measured brain repeated...

10.1176/appi.ajp.2013.11111745 article EN American Journal of Psychiatry 2013-06-04
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