A5058922815- Genetic Associations and Epidemiology
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Bioinformatics and Genomic Networks
- Substance Abuse Treatment and Outcomes
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Genetic Syndromes and Imprinting
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Alcohol Consumption and Health Effects
- Advanced Neuroimaging Techniques and Applications
- Gastrointestinal motility and disorders
- Psychiatric care and mental health services
- Healthcare Decision-Making and Restraints
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Diet and metabolism studies
- Glioma Diagnosis and Treatment
University of Oslo
2020-2025
Oslo University Hospital
2020-2025
King's College London
2018-2025
Akershus University Hospital
2023-2024
University of California, San Diego
2022
Weatherford College
2022
Université Paris Cité
2022
Inserm
2022
Genomics (United Kingdom)
2021
Imperial College London
2019
Psychiatric genetics has made substantial progress in the last decade, providing new insights into genetic etiology of psychiatric disorders, and paving way for precision psychiatry, which individual profiles may be used to personalize risk assessment inform clinical decision‐making. Long recognized heritable, recent evidence shows that disorders are influenced by thousands variants acting together. Most these commonly occurring, meaning every a each disorder, from low high. A series...
Objective: Mental disorders are heritable and polygenic, genome-wide genetic correlations (rg) have indicated widespread shared risk across multiple related traits, mirroring their overlapping clinical characteristics. However, rg may underestimate the underpinnings of mental traits because it does not differentiate mixtures concordant discordant effects from an absence overlap. Using novel statistical genetics tools, authors aimed to evaluate overlap between when accounting for mixed effect...
Malignant astrocytomas (MA) are aggressive central nervous system tumors with poor prognosis. Activating mutation of BRAF (BRAF(V600E)) has been reported in a subset these tumors, especially children. We have investigated the incidence BRAF(V600E) additional pediatric patient cohorts and examined effects blockade preclinical models wild-type MA.BRAF(V600E) status was two MA cohorts. For functional studies, cell lines were used to investigate shRNA knockdown vitro, pharmacologic inhibition...
Brain morphology has been shown to be highly heritable, yet only a small portion of the heritability is explained by genetic variants discovered so far. Here we extended Multivariate Omnibus Statistical Test (MOSTest) and applied it genome-wide association studies (GWAS) vertex-wise structural magnetic resonance imaging (MRI) cortical measures from N=35,657 participants in UK Biobank. We identified 695 loci for surface area 539 thickness, total 780 unique associated with robustly replicated...
Schizophrenia is a complex heritable disorder associated with many genetic variants, each small effect. While cortical differences between patients schizophrenia and healthy controls are consistently reported, the underlying molecular mechanisms remain elusive.To investigate extent of shared architecture brain surface area (SA) thickness (TH) to identify genomic loci.Independent genome-wide association study data on (Psychiatric Genomics Consortium CLOZUK: n = 105 318) SA TH (UK Biobank: 33...
Schizophrenia is associated with increased risk of cardiovascular disease (CVD), although there variation in among individuals. There are indications shared genetic etiology between schizophrenia and CVD, but the nature overlap remains unclear. The aim this study was to fill gap knowledge.Overlapping architectures CVD factors were assessed by analyzing recent genome-wide association (GWAS) results. bivariate causal mixture model (MiXeR) applied estimate number variants conjunctional false...
Psychiatric disorders and common epilepsies are heritable with a high comorbidity overlapping symptoms. However, the causative mechanisms underlying this relationship poorly understood. Here we aimed to identify genetic loci between epilepsy psychiatric gain better understanding of their shared clinical features. We analysed genome-wide association study data for all (n = 44 889), generalized 33 446), focal 39 348), schizophrenia 77 096), bipolar disorder 406 405), depression 500 199),...
Abstract Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of the heritability remains unidentified, overlap somatic disorders is not quantified beyond correlations. Here, we characterize architecture IBS, further, investigate its phenotypes, identify novel genomic loci. Methods Using GWAS summary statistics IBS (53,400 cases...
Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine less certain although glutamatergic serotonergic neurotransmission are implicated both. A shared genetic basis to mental disorders has been suggested but previous studies have reported weak non-significant correlations five risk loci. Using the largest samples date novel statistical tools, we aimed determine extent which migraine's polygenic architecture...
BackgroundA range of sleep disturbances are commonly experienced by patients with psychiatric disorders, and genome-wide genetic analyses have shown some significant correlations between these traits. Here, we applied novel statistical methodologies to better characterize the potential shared architecture sleep-related phenotypes disorders.MethodsUsing MiXeR method, which can estimate polygenic overlap beyond correlation, major disorders (bipolar disorder [N = 51,710], depression 480,359],...
Abstract Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) increases the risk of cardiovascular disease (CVD). However, mechanisms underlying relationship between loneliness, SMDs, CVD factors remain unknown. Here we explored overlapping genetic architecture loci shared factors. We analyzed large independent genome-wide association study data on schizophrenia (SCZ), bipolar disorder (BD), major depression (MD), using bivariate...
Epidemiological and clinical studies have found associations between depression cardiovascular disease risk factors, coronary artery patients with worse prognosis. The genetic relationship these phenotypes is not known. We here investigated overlap at the genome-wide level in individual loci depression, factors. used bivariate causal mixture model (MiXeR) to quantify polygenic conditional/conjunctional false discovery rate (pleioFDR) method identify shared loci, based on association study...
Personality and cognitive function are heritable mental traits whose genetic foundations may be distributed across interconnected brain functions. Previous studies have typically treated these complex as distinct constructs. We applied the 'pleiotropy-informed' multivariate omnibus statistical test to genome-wide association of 35 measures neuroticism from UK Biobank (n = 336,993). identified 431 significantly associated loci with evidence abundant shared associations, personality domains....
Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-wide association studies (GWAS) have identified genetic variants associated with SCZ and immune-related phenotypes. Here, we use cutting edge statistical tools to identify shared between white blood cell (WBC) counts further understand the role of immune system SCZ.GWAS results from (patients, n = 53 386; controls, 77 258) WBC (n 56 3085) were analyzed. We applied linkage disequilibrium score regression, conditional false...
Gene fusions involving members of the RAF family protein kinases have recently been identified as characteristic aberrations low-grade astrocytomas, most common tumors central nervous system in children. While it has shown that these cause constitutive activation ERK/MAPK pathway, very little is known about their formation. Here, we present a detailed analysis gene fusion breakpoints from well-characterized cohort 43 astrocytomas. Our findings show rearrangements generate may be simple or...
Premenstrual disorders are heritable, clinically heterogenous, with a range of affective spectrum comorbidities. It is unclear whether genetic predispositions to or other major psychiatric associated symptoms premenstrual disorders.