A5030244109- Ruminant Nutrition and Digestive Physiology
- Biotechnology and Related Fields
- Ecology and Vegetation Dynamics Studies
- Science, Research, and Medicine
- Genetic and phenotypic traits in livestock
- Pasture and Agricultural Systems
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Biomedical Ethics and Regulation
- Botany and Plant Ecology Studies
- ATP Synthase and ATPases Research
- Plant and animal studies
- Bioeconomy and Sustainability Development
- Agronomic Practices and Intercropping Systems
- Agroforestry and silvopastoral systems
- Reproductive Physiology in Livestock
- Turfgrass Adaptation and Management
- Animal Nutrition and Physiology
- Rangeland and Wildlife Management
- Cancer Genomics and Diagnostics
- Rangeland Management and Livestock Ecology
- CRISPR and Genetic Engineering
- Soil Carbon and Nitrogen Dynamics
- Plant and fungal interactions
University of Oxford
2015-2024
University of Sheffield
2012-2023
Neurological Surgery
2005-2023
Ariadne Diagnostics (United States)
2014-2023
Oxford Archaeology
2019-2023
SLAC National Accelerator Laboratory
1993-2022
Takeda (United States)
2022
Healthcentric Advisors
2022
Loughborough University
2017-2020
Edith Cowan University
2020
Plant functional traits are the features (morphological, physiological, phenological) that represent ecological strategies and determine how plants respond to environmental factors, affect other trophic levels influence ecosystem properties. Variation in plant traits, trait syndromes, has proven useful for tackling many important questions at a range of scales, giving rise demand standardised ways measure ecologically meaningful traits. This line research been among most fruitful avenues...
Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of tumorigenesis has been unclear. To explore phenomenon, we generated mice carrying hypomorphic methyltransferase 1 (Dnmt1) allele, which reduces Dnmt1 expression to 10% wild-type levels and results substantial genome-wide all tissues. The mutant were runted at birth, 4 8 months age they developed aggressive T cell lymphomas that displayed high frequency chromosome 15...
Abstract Question: A set of easily‐measured (‘soft’) plant traits has been identified as potentially useful predictors ecosystem functioning in previous studies. Here we aimed to discover whether the screening techniques remain operational widely contrasted circumstances, test for existence axes variation particular sets traits, and their links with ‘harder’ proven importance functioning. Location: central‐western Argentina, central England, northern upland Iran, north‐eastern Spain....
Abstract Background Glioblastoma multiforme (GBM) is an invariably fatal central nervous system tumor despite treatment with surgery, radiation, and chemotherapy. Further insights into the molecular cellular mechanisms that drive GBM formation are required to improve patient outcome. MicroRNAs emerging as important regulators of differentiation proliferation, have been implicated in etiology a variety cancers, yet role microRNAs remains poorly understood. In this study, we investigated...
A key element of most recently proposed plant strategy schemes is an axis resource capture, usage and availability. In the search for a simple, robust trait (or traits) that will allow plants to be located on this axis, specific leaf area one leading contenders. Using large new unpublished database, we examine variability other traits, relationships between them, their ability predict position use axis. Specific found suffer from number drawbacks; it both very variable replicates much...
An understanding of seed persistence in the soil is important to vegetation management and weed control, but experimental collection bank data tedious expensive. We report a rapid, simple method for predicting soil. The tested on range British, mostly herbaceous, species. Diaspore (seed or fruit) weight plotted against variance three linear dimensions diaspore. All diaspores within an area graph defined by maximum are persistent critical same fruits seeds, diaspore appears slightly higher...
In 1991, Terminology for Grazing Lands and Animals was published with the objective of ‘developing a consensus clear definitions terms used in grazing animals.’ This first effort involved primarily organizations agencies within USA but included representation from New Zealand Australia. It intent beginning to expand this truly international at later date. At XVII International Grassland Congress (IGC), held jointly Australia 1993, resolution passed final business meeting as follows: ‘It is...
A long-term research programme, conducted mainly in northern England, has involved field surveys (1965-77), laboratory screening (1974-96), monitoring of permanent plots (1958 to date) and manipulative experiments (1987 date). The so-called C-S-R classification plant functional types developed from all this activity. Patterns covariation among the traits used have recently been validated journal. appears be applicable vegetation general. It thus considerable potential for interpreting...
• Background and Aims Leaf thickness plays an important role in leaf plant functioning, relates to a species' strategy of resource acquisition use. As such, it has been widely used for screening purposes crop science community ecology. However, since its measurement is not straightforward, number estimates have proposed. Here, the validity (SLA × LDMC)−1 product tested estimate thickness, where SLA specific area (leaf area/dry mass) LDMC dry matter content mass/fresh mass). are two traits...
Cellular senescence irreversibly arrests cell proliferation in response to oncogenic stimuli. Human cells develop a senescence-associated secretory phenotype (SASP), which increases the secretion of cytokines and other factors that alter behavior neighboring cells. We show here "senescent" mouse fibroblasts, arrested growth after repeated passage under standard culture conditions (20% oxygen), do not express human-like SASP, differ from similarly cultured human respects. However, when...
The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical behaviour and response to therapy translates into an urgent need for robust molecular subclassifiers can explain this heterogeneity beyond current parameters (MSI, KRAS, BRAF). Attempts fill gap are emerging. Cancer Genome Atlas (TGCA) reported two main CRC groups, based on the incidence spectrum mutated genes, another paper EMT expression signature defined subgroup. We performed prior free analysis...
1 Using the data in a recently published seed bank database for north‐west Europe, we describe how species’ behaviour can be characterized by single ‘longevity index’, and investigate representative information is of European flora. We also test hypotheses that seeds short‐lived species are more persistent than those long‐lived species, characteristic living disturbed habitats. 2 The not flora as whole; they fair reflection research effort has been largely directed towards grassland arable...
S ummary The intensity of vesicular‐arbuscular mycorrhizal infection was assessed in the major vegetation types east‐central England. All most important species grassland, scrub and woodland were each individual any normally carried a heavy VA infection. Members Gramineae particularly heavily infected. In limestone extended to members Cyperaceae Juncaceae. Infection levels high throughout year, highest occurring nutrient‐stressed situations. Mycorrhiza develops soon after germination, often...
Abstract. 1. To determine whether rarity and decline is linked to organism ecology, associations have been examined between butterfly larval host‐plant competitive, stress‐tolerant, ruderal ( C‐S‐R ) strategies biology. 2. Associations sought mean scores for host plants with life history, morphology physiology variables, resource use, population attributes, geography, conservation status. Comparisons are carried out across species controlled phylogenetic patterning. 3. Butterfly biology...
Abstract A study was conducted to determine the influence of herbage mass under continuous stocking management with sheep on rates growth (G), senescence (S) and net production green (NP) in a mixed‐species sward Lolium perenne. Poa annua Trifolium repens. Plots were maintained as nearly constant possible at 500, 700, 1000 1700 kg organic matter (OM) ha −1 by but variable for period May July inclusive. Estimates G, S NP obtained each species from repeated measurements over two 2‐week periods...