A5088115842- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Temporomandibular Joint Disorders
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Cancer Research and Treatments
- Renal and related cancers
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Molecular Biology Techniques and Applications
- Glycosylation and Glycoproteins Research
- Wnt/β-catenin signaling in development and cancer
- Telomeres, Telomerase, and Senescence
- Estrogen and related hormone effects
- Renal cell carcinoma treatment
- Esophageal Cancer Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
University of Lausanne
2011-2024
Utrecht University
1993-2019
OLVG
2019
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
Q-Biologicals (Belgium)
2017
University Hospital of Lausanne
2006-2016
Maastricht University
1990-2016
University Hospital of Geneva
2009-2015
SIB Swiss Institute of Bioinformatics
2009-2015
Mutations within the KRAS proto-oncogene have predictive value but are of uncertain prognostic in treatment advanced colorectal cancer. We took advantage PETACC-3, an adjuvant trial with 3,278 patients stage II to III colon cancer, evaluate and BRAF tumor mutation status this setting.Formalin-fixed paraffin-embedded tissue blocks (n = 1,564) were prospectively collected DNA was extracted from sections 1,404 cases. Planned analysis exon 2 15 mutations performed by allele-specific real-time...
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and currently causes considerable confusion. A uniform framework for NENs at any anatomical location may reduce inconsistencies contradictions among the various in use. suggested here is intended to allow pathologists clinicians manage their patients with consistently, while acknowledging organ-specific differences criteria, tumor biology, prognostic factors. based on a consensus conference held International...
Few systematic studies have been published comparing the expression and distribution of endothelial cell (EC) markers in different vascular beds normal human tissues. We investigated by immunohistochemistry CD31, CD34, von Willebrand factor (vWF), Fli-1 EC major organs large vessels. Tissue samples obtained from autopsies biopsy specimens were routinely processed stained immunohistochemically for vWF. Biopsy material was also Fli-1, D2-40, Lyve-1. The pattern heterogeneous some studied. In...
The present study was undertaken to explore the possibility that neointimal smooth muscle cells, characteristic cells of restenosis and atherosclerosis, are selectively stimulated replicate by a hypertensive stimulus. Angiotensin II (AII) infused osmotic minipumps for 2 weeks in 4.5-month-old rats. Group A received AII (200 ng/min) after balloon catheter-induced injury thoracic aorta left common carotid artery. B only AII, group C denudation, D neither nor AII. During or Ringer's solution...
The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical behaviour and response to therapy translates into an urgent need for robust molecular subclassifiers can explain this heterogeneity beyond current parameters (MSI, KRAS, BRAF). Attempts fill gap are emerging. Cancer Genome Atlas (TGCA) reported two main CRC groups, based on the incidence spectrum mutated genes, another paper EMT expression signature defined subgroup. We performed prior free analysis...
Abstract Nuclei, isolated from paraffin‐embedded tissue, were stained with propidium iodide (PI) and found suitable for DNA analysis by flow cytometry (FCM). DNA‐derived fluorescence intensity, however, was always decreased had a much higher intersample variability as compared to results obtained fresh material. Using chicken red blood cells (CRBC) model system, we the lower intensity be due formalin fixation step in tissue processing. The at least partly caused variations duration of...
Timely perception of adverse environmental changes is critical for survival. Dynamic in gases are important cues plants to sense perturbations, such as submergence. In Arabidopsis thaliana, oxygen and nitric oxide (NO) control the stability ERFVII transcription factors. proteolysis regulated by N-degron pathway mediates adaptation flooding-induced hypoxia. However, how detect transduce early submergence signals remains elusive. Here we show that can rapidly through passive ethylene...
BackgroundThe prognostic potential of individual clinical and molecular parameters in stage II/III colon cancer has been investigated, but a thorough multivariable assessment their relative impact is missing.
Purpose Our purpose was development and assessment of a BRAF-mutant gene expression signature for colon cancer (CC) the study its prognostic implications. Materials Methods A set 668 stage II III CC samples from PETACC-3 (Pan-European Trails in Alimentary Tract Cancers) clinical trial were used to assess differential between c.1799T>A (p.V600E) BRAF mutant non-BRAF, non-KRAS cancers (double wild type) construct expression–based classifier detecting with high sensitivity. The validated...
Abstract Purpose: Mutation of BRAF at the valine 600 residue occurs in approximately 10% colorectal cancers, a group with particularly poor prognosis. The response mutant cancer to recent targeted strategies such as anti-BRAF or combinations MEK and EGFR inhibitors remains limited highly heterogeneous within V600E cohorts. There is clearly an unmet need understanding biology cancers potential subgroups this population. Experimental Design: In biggest yet reported cohort 218 gene expression...
Lymph node status is pivotal to the staging of colorectal carcinoma. The diagnosis a lymph negative tumor should imply good prognosis; however, outcomes for Dukes' B (TNM Stage II) patients remain variable, possibly in part due understaging. aim this study was determine whether examining specified minimum number nodes using conventional techniques would eliminate risk understaging and thus have an effect on prognosis.Data who underwent surgery carcinoma at single institution between 1985...
Abstract BACKGROUND Locally advanced rectal carcinoma has a poor prognosis. However, since the introduction of preoperative radiotherapy, outcome patients with been reported to have improved. Nevertheless, authors' knowledge few data are available regarding histopathologic response radiotherapy as assessed on surgical specimens potential predictive factor for outcome. METHODS To estimate effect carcinoma, authors retrospectively reviewed 102 T3‐4, N0 or ≥ N1 and 1 patient T2 but carcinoma....
Selecting the appropriate approach for resection and follow-up of pheochromocytomas (PCCs) is highly dependent upon reliable localization exclusion multifocal, bilateral, or metastatic disease. Metaiodobenzylguanidine (MIBG) scintigraphy was developed functional catecholamine-secreting tissues. Somatostatin receptor imaging (SRI) has a high sensitivity localizing head neck paragangliomas, but studies intraabdominal PCCs are rare. In this study we review our experience of[ 123I]MIBG SRI,...
DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It 1 of the mechanisms resulting gene silencing carcinogenesis, especially tumor suppressor genes (e.g., p16, Rb). Telomerase, polymerase adding TTAGGG repeats to chromosome end, regulation replicative life span by maintaining telomere length. This enzyme activated germ stem cells, repressed normal somatic cells reactivated a large majority cells. The promoter region hTERT gene, encoding...
A multivariate analysis of the pathologic data 350 patients with primary colorectal cancer was performed. In addition to conventional parameters such as shape and size tumor, central node involvement, angioinvasive growth, grade, stage, new variables immunoreactivity patterns carcinoembryonic antigen (CEA), CA 19-9, mucin, serotonin, secretory component (SC), DNA index were tested for their potential prognostic value. Every variable except showed significant information in univariate...