A5015502082- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Drug-Induced Hepatotoxicity and Protection
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Ubiquitin and proteasome pathways
- Axon Guidance and Neuronal Signaling
- Liver Disease and Transplantation
- Receptor Mechanisms and Signaling
- Craniofacial Disorders and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Birth, Development, and Health
- Corneal Surgery and Treatments
- Neurological disorders and treatments
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Liver physiology and pathology
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Hepatitis B Virus Studies
- Endoplasmic Reticulum Stress and Disease
- Neurogenesis and neuroplasticity mechanisms
Paris Biotech Santé
2022
Délégation Ile-de-France Villejuif
2020
Inserm
2001-2017
Alfact Innovation (France)
2010-2016
OZ Biosciences (France)
2005
Canada Research Chairs
2003
University of Toronto
1999-2003
Lunenfeld-Tanenbaum Research Institute
1999-2002
Mount Sinai Hospital
2002
Centre National de la Recherche Scientifique
1994-1998
The expansion of a polyglutamine tract in the ubiquitously expressed huntingtin protein causes Huntington's disease (HD), dominantly inherited neurodegenerative disease. We show that activity cholesterol biosynthetic pathway is altered HD. In particular, transcription key genes severely affected vivo brain tissue from HD mice and human postmortem striatal cortical tissue; this molecular dysfunction biologically relevant because biosynthesis reduced cultured cells, total mass significantly...
Spinocerebellar ataxia 12 (SCA12) is an autosomal dominant cerebellar (ADCA) described in a single family with CAG repeat expansion the PPP2R2B gene. We screened 247 index cases, including 145 families ADCA, for this expansion. An expanded ranging from 55 to 61 triplets was detected 6 affected and 3 unaffected individuals at risk India. The association of disease new provides additional evidence that mutation causative. Ann Neurol 2001;49:117–121
In order to test the role of mu and kappa opioid receptors (Mu receptor (MOR) Kappa (KOR)) in hippocampal‐dependent spatial learning, we analyzed genetically engineered null mutant mice missing functional MOR or KOR gene. Compared wild‐type mice, homozygous mutants exhibited an impairment ultimate level learning as shown two distinct tasks, 8‐arm radial‐maze Morris water‐maze. Control behaviors were normal. The could be associated with found maintenance long‐term potentiation mossy fibers...
Acute liver failure (ALF) is a rare syndrome with difficult clinical management and high mortality rate. During ALF, several molecular pathways governing oxidative stress apoptosis are activated to induce massive tissue injury suppress cell proliferation. There few anti-ALF drug candidates, among which the C-type lectin Reg3α, or human hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP), displayed promising properties for regeneration protection against cellular in...
No efficient medical treatment is available for severe acute hepatitis (SAH) except N-acetylcysteine acetaminophen-induced liver failure. The human C-type lectin Reg3α, referred to as ALF-5755, improved survival in an animal model of failure and was well tolerated a phase 1 trial humans. We performed 2a ALF5755 non-acetaminophen induced SAH.double-blind, randomized, placebo-controlled study. primary end-point the improvement coagulation protein synthesis assessed by change Prothrombin (PR)...
Abstract Background The aim of this study was to investigate the effects prenatal alcohol exposure on radial-maze learning and hippocampal neuroanatomy, particularly sizes intra- infrapyramidal mossy fiber (IIPMF) terminal fields, in three inbred strains mice (C57BL/6J, BALB/cJ, DBA/2J). Results Although we anticipated a modification both IIPMF sizes, no such were detected. Prenatal did, however, interfere with reproduction C57BL/6J animals decrease body brain weight (in interaction...
The aim of our study was to test the hypothesis that administration Regenerating islet-derived protein 3α (Reg3α), a described as having protective effects against oxidative stress and anti-inflammatory activity, could participate in control glucose homeostasis potentially be new target interest treatment type 2 diabetes. To end recombinant human Reg3α administered for one month insulin-resistant mice fed high fat diet. We performed insulin tolerance tests, assayed circulating chemokines...
239 m/s n° 3, vol. 28, mars 2012 DOI : 10.1051/medsci/2012283004 3 Arabidopsis Interactome Mapping Consortium. Evidence for network evolution in an interactome map. Science 2011 ; 333 601-7. 4 Mukhtar MS, Carvunis AR, Dreze M, et al. Independently evolved virulence effectors converge onto hubs a plant immune system network. 596-601. 5 Dangl JL, Jones JD. Plant pathogens and integrated defence responses to infection. Nature 2001 411 826-33. 6 Albert R, Jeong H, Barabasi AL. Error attack...
Purpose Ocular development may be disrupted at various stages, leading to a wide range of congenital ocular dysgenesis. Incidence such defects is estimated 1-2 in 10.000. They isolated or associated with extra-ocular malformations. In addition, psychomotor delay present, secondary the sensory involvement linked cerebral developmental anomaly intellectual disability. Visual outcome, frequency features and are still poorly known. Given rarity these malformations, available data concern very...
Introduction: REG3A (Regenerating islet-derived protein 3A) is a carbohydrate-binding belonging to the family of C-type lectins. has antioxidant and anti-inflammatory properties modulating glucose lipid homeostasis. We report study effects administration human recombinant ALF-5755 on homeostasis in insulin-resistant mice. Materials Methods: 4-week-old C57Bl/6N male mice were fed HFD for 12 weeks. The control group received standard chow diet. 12-week-old Ob/Ob used. Mice given (43µg/day, ALF...
The aim of our study was to test the hypothesis that administration Regenerating islet-derived protein 3α (Reg3α), a described as having antioxidant effects via its action on extracellular matrix, could participate in control glucose homeostasis and potentially be new target interest treatment type 2 diabetes. To end recombinant human Reg3α administered for one month insulin-resistant mice fed high fat diet. We evidenced an increase insulin sensitivity during oral tolerance ALF-5755 treated...