A5025554009- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Treatments and Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Hepatitis C virus research
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- Organ Donation and Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Liver physiology and pathology
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Biliary and Gastrointestinal Fistulas
- Surgical Simulation and Training
- Multiple and Secondary Primary Cancers
- Renal cell carcinoma treatment
- Nutrition and Health in Aging
Hôpital Paul-Brousse
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2016-2025
Université Paris-Saclay
2016-2025
Physiopathogénèse et Traitement des Maladies du Foie
2020-2024
Université Paris-Sud
2014-2024
Laboratoire d'études sur les monothéismes
2009-2023
Hôpitaux Universitaires Henri-Mondor
2023
Institut Mines-Télécom
2021-2023
Télécom Paris
2023
This paper describes a 10-year experience of laparoscopic liver surgery, including several major hepatectomies for malignant tumours.Of 243 carried out between January 1995 and December 2004, 113 (46.5 per cent) were performed by laparoscopy 89 included in this retrospective study.Twenty-four (27 benign disease 65 (73 tumours, hepatocellular carcinoma (HCC) 16 patients colorectal metastasis (CRM) 41. Minor hepatectomy was 51 (three or more Couinaud segments) 38. Conversion to laparotomy...
To assess feasibility, risks, and long-term outcome of 2-stage hepatectomy as a means to improve resectability colorectal liver metastases (CLM).Two-stage uses compensatory regeneration after first noncurative enable second curative resection.Between October 1992 January 2007, among 262 patients with initially irresectable CLM, 59 (23%) were planned for hepatectomy. Patients eligible when single resection could not achieve complete treatment, even in combination chemotherapy, portal...
The presence of an intrahepatic cholangiocarcinoma (iCCA) in a cirrhotic liver is contraindication for transplantation most centers worldwide. Recent investigations have shown that “very early” iCCA (single tumors ≤2 cm) may acceptable results after transplantation. This study further evaluates this finding larger international multicenter cohort. group was composed those patients who were transplanted hepatocellular carcinoma or decompensated cirrhosis and found to at explant pathology....
Compare oncologic results of laparoscopic versus open hepatectomy for resection colorectal metastases to the liver.Open (OH) is current standard care management liver metastases. Although feasibility (LH) has been established, only select centers have used this technique as their primary modality. At present there no study comparing outcomes patients undergoing LH OH.Two groups composed 60 each were obtained from 2 specialized units performing either OH or Cohorts 215 cases and 1783...
Intrahepatic cholangiocarcinoma (ICC) is a severe malignant tumor in which the standard therapies are mostly ineffective. The biological significance of desmoplastic microenvironment (TME) ICC has been stressed but was insufficiently taken into account search for classifications adapted to clinical trial design. We investigated heterogeneous stroma composition and built TME-based classification tumors that detects potentially targetable subtypes.We established bulk gene expression profiles...
Locoregional extension of intrahepatic cholangiocarcinoma (ICC) at the time diagnosis results in a low resectability rate and poor prognosis. The aim this retrospective study was to assess efficacy neoadjuvant chemotherapy for locally advanced ICC.All consecutive patients with ICC between 2000 2013 were included prospectively single-centre database analysed retrospectively. Patients considered as initially unresectable received primary chemotherapy, followed by surgery those secondary...
Liver transplantation (LT) for cirrhotic/Hepatocellular carcinoma (HCC) is associated with reduced survival in patients poor histological features. Preoperative levels of alphafetoprotein (AFP) could predict negative biological AFP progression be more relevant than static predicting LT outcomes. A total 252 cirrhotic/HCC transplanted between 1985 and 2005 were reviewed. One hundred fifty-three analyzed, 99 excluded (for nonsecreting tumors and/or salvage transplantation). Using receiver...
Although sarcopenia is a common complication of cirrhosis, its diagnosis remains nonconsensual: computed tomography (CT) scan determinations vary and no cutoff values have been established in cirrhotic populations undergoing liver transplantation (LT). Our aim was to compare the accuracy most widely used measurement techniques establish useful cutoffs setting LT. From 440 patients transplanted between January 2008 May 2011 our tertiary center, we selected 256 with cirrhosis for whom recent...
Abstract For patients who have cirrhosis with hepatocellular carcinoma (HCC), living donor liver transplantation (LDLT) reduces waiting time and dropout rates. We performed a comparative intention-to-treat analysis of recurrence rates survival outcomes after LDLT deceased (DDLT) in HCC patients. Our study included 183 consecutive were listed for over 9-year period at our institution. Tumor was the primary endpoint. At listing, patient tumor characteristics comparable two groups (LDLT, n =...
Abstract Background The optimal surgical strategy for patients with synchronous colorectal liver metastases (CLMs) is still unclear. aim of this study was to compare simultaneous and hepatic resection a delayed in who had limited hepatectomy (fewer than three segments). Methods All CLMs underwent between 1990 2006 were included retrospectively. Short-term outcome, overall progression-free survival compared having those treated by hepatectomy. Results Of 228 undergoing CLMs, 55 (24·1 per...
To evaluate the impact of location extrahepatic disease (EHD) on survival and to determine patient outcome in a consecutive series patients with both intrahepatic colorectal metastases treated by an oncosurgical approach, combining repeat surgery chemotherapy.Although recognized as poor prognostic factor, concomitant EHD is no more considered absolute contraindication liver (CLM). However, benefit still diversely appreciated.From 840 resected for CLM between 1990 2006, 186(22%) also had...
Histological alterations often constitute a fingerprint of toxicity and diseases. The extent to which these are cause or consequence compromised organ function, the underlying mechanisms involved is matter intensive research. In particular, liver disease associated with altered tissue microarchitecture, in turn may compromise perfusion functionality. Research this field requires development orchestration new techniques into standardized processing pipelines that can be used reproducibly...
In Brief Objectives: To evaluate the predictive value of portal vein pressure (PVP) after major liver resection for posthepatectomy failure (PLF) and 90-day mortality in patients without cirrhosis. Background: As elevated PVP is associated with living donor transplantation, we hypothesized that outcome hepatectomy may be influenced by PVP. Patients Methods: All severe fibrosis or cirrhosis who underwent a (≥3 segments) an intraoperative measurement at end procedure were included. Outcome was...
Abstract Background Although associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been increasingly adopted by many centres, the oncological outcome colorectal metastases compared with that after two-stage is still unknown. Methods Between January 2010 June 2014, all consecutive patients who underwent either ALPPS or in a single institution were included study. Morbidity, mortality, disease recurrence survival compared. Results The two groups comparable...
In compensated cirrhotics with early hepatocellular carcinoma (HCC-cirr), upfront liver resection (LR) and salvage transplantation (SLT) in case of recurrence may have outcomes comparable to primary LT (PLT).An intention-to-treat (ITT) analysis comparing PLT SLT strategies.Of 130 HCC-cirr patients who underwent LR (group LR), 90 (69%) recurred, 31 could undergo SLT). During the same period, 366 were listed for LLT); 26 dropped-out (7.1%), 340 finally PLT). We compared survival between groups...
The purpose of this study was to determine the optimal definition and elucidate predictive factors early recurrence after surgery for colorectal liver metastases (CRLM).Among 987 patients who underwent curative CRLM from 1990 2012, 846 with a minimum follow-up period 24 months were eligible study. p value approach survival initial used cutoff recurrence. prognostic analyzed.For 667 (79%) developed recurrence, point determined be 8 surgery. impact on demonstrated mainly in received...
Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is widely considered as a terminal condition. Therefore, the role surgery uncertain in this case. The purpose study was to identify prognostic factors survival post‐LT HCC recurrence and evaluate impact setting. All patients transplanted for between 1991 2013 single institution who further developed were included study. Univariate multivariate analyses performed affecting postrecurrence survival. Of 493 HCC, total...