A5068165371- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Viral-associated cancers and disorders
- Alcohol Consumption and Health Effects
- Hepatitis C virus research
- Colorectal Cancer Treatments and Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Liver physiology and pathology
- Organ Donation and Transplantation
- Abdominal Trauma and Injuries
- Neuroendocrine Tumor Research Advances
- Transplantation: Methods and Outcomes
- Hepatitis B Virus Studies
- Biliary and Gastrointestinal Fistulas
- Colorectal Cancer Surgical Treatments
- Cancer, Hypoxia, and Metabolism
- Polyomavirus and related diseases
- Nutrition and Health in Aging
- Pediatric Hepatobiliary Diseases and Treatments
Université de Lille
2008-2025
Hôpital Claude Huriez
2015-2024
Centre Hospitalier Universitaire de Lille
2015-2024
Lille’s Cardiology Hospital
2024
Inserm
2008-2024
Hôpital Edouard Herriot
2014-2023
Université Claude Bernard Lyon 1
2023
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2022
Assistance Publique – Hôpitaux de Paris
2009-2021
Sorbonne Université
2001-2021
A 6-month abstinence from alcohol is usually required before patients with severe alcoholic hepatitis are considered for liver transplantation. Patients whose not responding to medical therapy have a survival rate of approximately 30%. Since most deaths occur within 2 months, early transplantation attractive but controversial.We selected seven centers The had no prior episodes and scores 0.45 or higher according the Lille model (which calculates ranging 0 1, score ≥ indicating nonresponse an...
Early identification of patients with severe (discriminant function ≥ 32) alcoholic hepatitis (AH) not responding to corticosteroids is crucial. We generated a specific prognostic model (Lille model) identify candidates early on for alternative therapies. Three hundred twenty AH prospectively treated by were included in the development cohort and 118 its validation. Baseline data change bilirubin at day 7 tested. The was logistic regression. combining six reproducible variables (age, renal...
Define the optimal surgical margin in patients undergoing surgery for intrahepatic cholangiocarcinoma (IHCC).Surgery is most effective treatment IHCC. However, influence of R1 resection on outcome controversial and that width has not been evaluated.We studied 212 curative mass-forming-type The respective influences survival status (R0 vs R1), width, pTNM stage, latter's components were evaluated.Incidence was 24%. Overall, an independent predictor [odds ratio (OR) 1.2 (0.7-2.1)] contrast to...
In Brief Background: Hepatic epitheloid hemangioendothelioma (HEHE) is a rare low-grade vascular tumor. Its treatment algorithm still unclear mainly due to lack of larger clinical experiences with detailed long-term follow-up. Material and Methods: Fifty-nine patients, reported the European Liver Transplant Registry, were analyzed define role liver transplantation (LT) in this disease. Eleven (19%) patients asymptomatic. Eighteen (30.5%) had pre-LT surgical [hepatic (7 patients) extrahepatic...
In alcoholic hepatitis (AH), development of targeted therapies is crucial and requires improved knowledge cellular molecular drivers in liver dysfunction. The unique opportunity using explanted livers from patients with AH having undergone salvage transplantation allowed to perform more in-depth translational studies.We studied explants submitted (n=16), cirrhosis without (n=12) fragments normal (n=16). Hepatic cytokine content was quantified. Hepatocyte function proliferation the presence...
Abstract Background Preoperative measurement of hepatic venous pressure gradient (HVPG) is not performed routinely before hepatectomy in patients with cirrhosis, although it has been suggested to be useful. This study investigated whether preoperative HVPG values and indirect criteria portal hypertension (PHT) predict the postoperative course these patients. Methods Between January 2007 December 2009, consecutive resectable hepatocellular carcinoma (HCC) a cirrhotic liver were included this...
Oxygen consumption at peak exercise (peak VO2) is the most accurate index of aerobic capacity (AC), which reflects physical condition an individual and currently considered gold standard for cardiorespiratory fitness. Evaluation VO2 to identify high-risk candidates liver transplantation (LT) may represent interesting approach. The aims this study were (a) describe AC factors independently associated with VO2; (b) analyze prognostic value in patients referred preliminary evaluation LT; (c)...
Liver transplantation for hilar cholangiocarcinoma (hCCA) has regained attention since the Mayo Clinic reported their favorable results with use of a neo-adjuvant chemoradiation protocol. However, debate remains whether success protocol should be attributed to therapy or strict selection criteria that are being applied. The aim this study was investigate value patient alone on outcome liver hCCA. In retrospective study, patients were transplanted hCCA between1990 and 2010 in Europe...
This multicenter study compares the outcomes of patients with cirrhosis undergoing liver transplantation (LT) or resection (LR) between January 2002 and July 2015 who had intrahepatic cholangiocarcinoma (iCCA) combined hepatocellular‐cholangiocarcinoma (cHCC‐CCA) found incidentally in native liver. A total 49 (65%) LT 26 (35%) LR histologically confirmed iCCA/cHCC‐CCA ≤5 cm were retrospectively analyzed. significantly lower tumor recurrence (18% versus 46%; P = 0.01), for which median...
Abstract Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal mixed features of both, causing diagnostic uncertainty and difficulty in determining proper management. Here, we perform a comprehensive deep learning-based phenotyping multiple cohorts patients. We show that learning can reproduce the diagnosis HCC...
3500 Background: Despite the increasing efficacy of chemotherapy (CT) and advances in surgical techniques for initially unresectable colorectal liver metastases (uCLM), secondary resection rate remains low. For definitively uCLM, CT standard care but transplantation (LT) has shown promising results. This first randomized trial aimed to assess combined LT uCLM. Methods: Patients with uCLM from resected BRAF non mutated cancer, having responded (≥ 3 months ≤ lines) absence extrahepatic...
Aliment Pharmacol Ther 2011; 34: 1193–1201 Summary Background Sorafenib increases median survival and time to radiological progression in patients with advanced hepatocellular carcinoma, but its benefit for Child-Pugh B remains uncertain. Aim To evaluate the safety efficacy of sorafenib real-life clinical practice conditions assess influence class on efficacy. Methods All treated carcinoma our institution were included prospectively. Adverse events, overall recorded. A case control study was...