A5041279223- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Transplantation: Methods and Outcomes
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Organ Donation and Transplantation
- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Metastasis and carcinoma case studies
- Peripheral Artery Disease Management
- Renal cell carcinoma treatment
- Esophageal and GI Pathology
- Hepatitis C virus research
- Cardiac, Anesthesia and Surgical Outcomes
- Genetic and Kidney Cyst Diseases
- Abdominal vascular conditions and treatments
- Anorectal Disease Treatments and Outcomes
- Vascular Procedures and Complications
Jena University Hospital
2016-2025
Friedrich Schiller University Jena
2015-2025
Klinikum Magdeburg
2016-2025
Comprehensive Cancer Center Mainfranken
2024
Yahoo (United Kingdom)
2023
Universitätsklinikum Würzburg
2023
RWTH Aachen University
2022
Maastricht University
2022
Center for Clinical Studies
2009-2021
University Gastroenterology
2020
Selection of patients suffering from hepatocellular carcinoma (HCC) in cirrhosis for liver transplantation follows limits number and diameter tumor nodules. It has not been investigated whether there is a correlation these parameters with vascular invasion. From 1989 to 2000, 1,188 transplantations were performed 1,087 patients, including 120 (11%) an HCC cirrhosis. criteria maximal up 5 cm if the appeared be uninodular or 3 case 2 The postoperative mortality rate was 1.7%. One–, 5–, 10–year...
We investigated whether sirolimus-based immunosuppression improves outcomes in liver transplantation (LTx) candidates with hepatocellular carcinoma (HCC).In a prospective-randomized open-label international trial, 525 LTx recipients HCC initially receiving mammalian target of rapamycin inhibitor-free were randomized 4 to 6 weeks after into group on (group A: 264 patients) or incorporating sirolimus B: 261). The primary endpoint was recurrence-free survival (RFS); intention-to-treat (ITT)...
<h3>Background & Aims</h3> Little is known about outcomes of liver transplantation for patients with non-alcoholic steatohepatitis (NASH). We aimed to determine the frequency and NASH in Europe identify prognostic factors. <h3>Methods</h3> analysed data from transplanted end-stage disease between January 2002 December 2016 using European Liver Transplant Registry database. compared versus other aetiologies. The principle endpoints were patient overall allograft survival. <h3>Results</h3>...
Predicting the clinical outcome of cancer patients based on expression marker genes in their tumors has received increasing interest past decade. Accurate predictors and response to therapy could be used personalize thereby improve therapy. However, state art methods so far often found with limited prediction accuracy, reproducibility, unclear biological relevance. To address this problem, we developed a novel computational approach identify prognostic for that couples gene measurements from...
The incidence, clinical presentation, therapeutic options, and outcome of hepatic artery thrombosis (HAT) were analyzed in a series 1,192 consecutive adult orthotopic liver transplantations (OLTs). HAT after OLT was observed 30 cases, resulting an incidence 2.5%. increased 5.76-fold when the donor reconstructed with interposition graft to supraceliac aorta (P <.05). Early (within first days OLT) occurred 14 these patients (46.7%), whereas 16 (53.3%), beyond post-OLT. Clinical presentation...
Liver transplantation in patients with hepatitis B has been under discussion for 20 years because of inferior results without reinfection prophylaxis; therefore, we analyzed our overall experience liver immunoprophylaxis, particularly the influence available antiviral treatment different periods. From 1988 to 2000, 228 transplants 206 were performed. Indications acute failure (10%), virus (HBV) cirrhosis alone (67%) or D (HDV) (13%), C (HCV) coinfection (7%). All received long-term...
Posttransplant immunosuppression with calcineurin inhibitors (CNIs) is associated impaired renal function, while mTor such as everolimus may provide a renal-sparing alternative. In this randomized 1-year study in patients liver transplantation (LTx), we sought to assess the effects of on glomerular filtration rate (GFR) after conversion from CNIs compared continued CNI treatment. Eligible received basiliximab induction, with/without corticosteroids for 4 weeks post-LTx, and were then (if GFR...
Hydroxyethyl starch 200 is associated with renal impairment in sepsis, but hydroxyethyl 130/0.4 and gelatin are considered to be less harmful. We hypothesized that fluid therapy only crystalloids would decrease the incidence of acute kidney injury.Prospective sequential comparison during intensive care unit stay.Surgical unit.Patients severe sepsis.Changes standard therapy, predominantly 6% from January 2005 June 2005, 4% 2006 2006, September 2008 2009.Acute injury was defined by presence at...
The aim of this study was to evaluate the survival benefit sirolimus in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) (exploratory analysis SiLVER-trial).Patients receiving LT) HCC are at a high risk tumor recurrence. Calcineurin inhibitors have shown evidence promote cancer growth, whereas mammalian target rapamycin (mTOR) like anticancer effects. In SiLVER-trial (Clinicaltrials.gov: NCT00355862), effect on recurrence after LT investigated prospective...
Liver transplantation for hilar cholangiocarcinoma (hCCA) has regained attention since the Mayo Clinic reported their favorable results with use of a neo-adjuvant chemoradiation protocol. However, debate remains whether success protocol should be attributed to therapy or strict selection criteria that are being applied. The aim this study was investigate value patient alone on outcome liver hCCA. In retrospective study, patients were transplanted hCCA between1990 and 2010 in Europe...
The prevalence of obesity is increasing at an alarming rate in industrialized countries. Obesity a systemic disease that causes not only macroscopic alterations, but also mitochondrial dysfunction. Laparoscopic sleeve gastrectomy (LSG) poses potential therapeutic option for patients with severe obesity. In order to ascertain the efficacy bariatric interventions, it important assess weight loss, changes body composition. Additionally, aim this study was investigate association between loss...
Complications involving the portal vein or vena cava, are rare after orthotopic liver transplantation. We report on incidence and treatment of venous complications following 1000 transplantations in 911 patients. Twenty‐six adult patients (2.7%) suffered from transplantation, whereas cava were observed only 17 (1.8%). Technical problems recurrence underlying disease (e.g. Budd–Chiari syndrome) accounted for majority alteration vessel wall splenectomy during transplantation could be...
Right lobe living donor liver transplantation (LD-LTx) is currently performed at an increasing number of transplant centers. Donor selection, safety, recovery, and postdonation psychological impairment are essential criteria to determine whether under which conditions LD-LTx justifiable. Before commencing the program, approval was obtained from local ethics committee. Potential donors underwent a comprehensive multistep evaluation protocol exclude any that could lead increased operative...
Purpose: To prospectively develop equations for the calculation of expected intraoperative weight and volume a living donor's right liver lobe by using preoperative computed tomography (CT) volumetric measurement. Materials Methods: After medical ethics committee state board approval, informed consent was obtained from eight female male donors (age range, 18–63 years) participation in CT measurement lobes summation-of-area method. Intraoperatively, graft weighed, determined means water...
Studies in intensive care unit (ICU) patients have suggested that anemia and blood transfusions can influence outcomes, but these effects not been widely investigated specifically surgical ICU patients.We retrospectively analyzed the prospectively collected data from all adult (>18 years old) admitted to a 50-bed between 1st March 2004 30th July 2006.Of 5925 during study period, 1833 (30.9%) received transfusion ICU. Hemoglobin concentrations were < 9 g/dl on at least one occasion 57.6% of...
We investigated the incidence of, outcome from and possible risk factors for readmission to surgical intensive care unit (ICU) at Friedrich Schiller University Hospital, Jena, Germany.We conducted an analysis of prospectively collected data all patients admitted postoperative ICU between September 2004 July 2006.Of 3169 during study period, 2852 were discharged hospital floor these made up group (1828 male (64.1%), mean patient age 62 years). The rate was 13.4% (n = 381): 314 (82.4%)...
The feasibility of de novo everolimus without calcineurin inhibitor (CNI) therapy following liver transplantation was assessed in a multicenter, prospective, open-label trial. Liver transplant patients were randomized at 4 weeks to start and discontinue CNI, or continue their current CNI-based regimen. primary endpoint adjusted estimated GFR (eGFR; Cockcroft-Gault) month 11 postrandomization. A 24-month extension phase followed 81/114 (71.1%) eligible 35 mean eGFR benefit from randomization...
DIAMOND: multicenter, 24-week, randomized trial investigating the effect of different once-daily, prolonged-release tacrolimus dosing regimens on renal function after de novo liver transplantation. Arm 1: (initial dose 0.2mg/kg/day); 2: (0.15-0.175mg/kg/day) plus basiliximab; 3: (0.2mg/kg/day delayed until Day 5) basiliximab. All patients received MMF a bolus corticosteroid (no maintenance steroids).eGFR (MDRD4) at Week 24. Secondary endpoints: composite efficacy failure, BCAR and AEs....
The aim of extracorporeal albumin dialysis (ECAD) is to reduce endogenous toxins accumulating in liver failure. To date, ECAD conducted mainly with the Molecular Adsorbents Recirculating System (MARS). However, single-pass (SPAD) has been proposed as an alternative. this study was compare two devices a prospective, single-centre, non-inferiority crossover design particular focus on reduction bilirubin levels (primary endpoint) and influence paraclinical clinical parameters (secondary...