A5103235554- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Aldose Reductase and Taurine
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Cancer, Lipids, and Metabolism
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Liver Disease and Transplantation
- Adipose Tissue and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Cancer Mechanisms and Therapy
- Caveolin-1 and cellular processes
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Endoplasmic Reticulum Stress and Disease
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Research and Treatments
University of Hong Kong
2015-2024
Chinese University of Hong Kong
2015-2024
Hong Kong Jockey Club
2023-2024
Binus University
2023
VA Loma Linda Healthcare System
2022
Population Health Research Institute
2021
McMaster University
2021
Queen Mary Hospital
1958-2019
State Key Laboratory of Synthetic Chemistry
2014-2018
Prince of Wales Hospital
2017
Poor prognosis of cancers, including hepatocellular carcinoma (HCC), is mainly associated with metastasis; however, the underlying mechanisms remain poorly understood. This article investigates role lysyl oxidase-like 2 (LOXL-2) in biology HCC metastasis. First, we showed that metastasis relies on a collagen-modifying enzyme, LOXL2, which was significantly overexpressed tumorous tissues and sera patients, indicating LOXL2 may be good diagnostic marker for patients. Second, delineated...
A population of stromal cells, myeloid‐derived suppressor cells (MDSCs), is present in tumors. Though studies have gradually revealed the protumorigenic functions MDSCs, molecular mechanisms guiding MDSC recruitment remain largely elusive. Hypoxia, O 2 deprivation, an important factor tumor microenvironment solid cancers, whose growth often exceeds functional blood vessels. Here, using hepatocellular carcinoma as cancer model, we show that hypoxia driver recruitment. We observed MDSCs...
Objective We investigated the effect and mechanism of hypoxic microenvironment hypoxia-inducible factors (HIFs) on hepatocellular carcinoma (HCC) cancer stemness. Design HCC stemness was analysed by self-renewal ability, chemoresistance, expression stemness-related genes stem cell (CSC) marker-positive population. Specific small ubiquitin-like modifier (SUMO) proteases 1 (SENP1) mRNA level examined with quantitative PCR in human paired HCCs. Immunoprecipitation used to examine binding...
Although Dickkopf-1 (DKK1) is known to be a negative regulator of the Wnt/β-catenin pathway, it has been recently found upregulated in cancers.We investigated clinical and prognostic significance both serum transcript DKK1 its functional roles human hepatocellular carcinoma (HCC).We evaluated expression level tissue samples from patients with HCC using GeneChip microarray real-time-quantitative PCR sandwich ELISA system respectively. The clinicopathological levels was examined. Functional...
The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process involving the progressive accumulation molecular alterations pinpointing different and cellular events. next-generation sequencing technology facilitating global systematic evaluation landscapes in HCC. There emerging evidence supporting importance cancer metabolism tumor microenvironment providing favorable supportive niche to expedite HCC development. Moreover, recent studies have identified distinct surface markers...
Cancer metastasis is a multistep process that involves series of tumor‐stromal interaction, including extracellular matrix (ECM) remodeling, which requires concerted action multiple proteolytic enzymes and their endogenous inhibitors. This study investigated the role tissue inhibitor metalloproteinases (TIMP) 2 in context hepatocellular carcinoma (HCC) metastasis. We found TIMP2 was most significantly down‐regulated member among TIMP family human HCCs. Moreover, underexpression frequent...
Abstract Frequent relapse and drug resistance in patients with hepatocellular carcinoma (HCC) can be attributed to the existence of tumor-initiating cells (TIC) within tumor bulk. Therefore, targeting liver TICs may improve prognosis these patients. From transcriptome sequencing 16 pairs clinical HCC samples, we report that interleukin-1 receptor-associated kinase 1 (IRAK1) TLR/IRAK pathway is significantly upregulated HCC. IRAK1 overexpression was further confirmed at mRNA protein levels...
Abstract Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal mixed features of both, causing diagnostic uncertainty and difficulty in determining proper management. Here, we perform a comprehensive deep learning-based phenotyping multiple cohorts patients. We show that learning can reproduce the diagnosis HCC...
Hepatocellular carcinoma (HCC) is an aggressive tumor, with a high mortality rate due to late symptom presentation and frequent tumor recurrences metastasis. It also rapidly growing supported by different metabolic mechanisms; nevertheless, the biological molecular mechanisms involved in reprogramming HCC are unclear. In this study, we found that pyruvate kinase M2 (PKM2) was frequently over-expressed human HCCs its over-expression associated clinicopathological features poor prognosis of...
Sox9, an SRY-related HMG box transcription factor, is a progenitor/precursor cell marker of the liver expressed during embryogenesis and following injury. In this study, we investigated role Sox9 its molecular mechanism with reference to stemness properties in hepatocellular carcinoma (HCC). Here, observed upregulation human HCC tissues compared non-tumorous counterparts (p < 0.001). Upregulation transcript level was associated poorer tumor differentiation = 0.003), venous invasion 0.026),...
// Carmen Oi-ning Leung 1 , Chak-lui Wong 1,2 Dorothy Ngo-yin Fan Alan Ka-lun Kai Edmund Kwok-kwan Tung Iris Ming-jing Xu Irene Oi-lin Ng and Regina Cheuk-lam Lo Department of Pathology, The University Hong Kong, China 2 State Key Laboratory for Liver Research, Correspondence to: Lo, email: Ng, Keywords : PIM1, HCC, metastasis Received October 30, 2014 Accepted February 18, 2015 Published March 12, Abstract Hepatocellular carcinoma (HCC) is characteristically one the most rapidly...
Background & AimsIn some individuals with undetectable serum levels of hepatitis B surface antigen (HBsAg), virus (HBV) DNA can still be detected in or hepatocytes and HBV replicates at low levels—this is called occult infection (OBI). OBI has been associated increased risk hepatocellular carcinoma (HCC). We investigated the incidence patients HCC other liver diseases. also whether, HCC, integrated into hepatocytes.MethodsWe collected clinical information tissues from 110 HBsAg-negative (90...
Identification and characterization of functional molecular targets conferring stemness properties in hepatocellular carcinoma (HCC) offers crucial insights to overcome the major hurdles tumor recurrence, metastasis chemoresistance clinical management. In current study, we investigated significance Cripto-1 contributing HCC stemness. was upregulated sorafenib-resistant clones derived from cell lines patient-derived xenograft that previously developed, suggesting an association between By...
Objective We examined the serological, virological (in serum and liver) histological profiles in chronic hepatitis B virus (HBV) patients during after completion of multiple dose (MD) ARC-520. Design The present phase 1b study was a multidose, open-label extension cohort that had received single ARC-520 our previous study. Eight 4–9 4 weekly doses MD entecavir. Liver biopsies were performed six patients. Intrahepatic HBV DNA, RNA viral antigens measured. Results All 28.9–30.4 months...
AIM:To analyze whether high-intensity focused ultrasound (HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma (HCC). METHODS:From January 2007 to December 2010, 49 consecutive HCC were listed liver transplantation (UCSF criteria).The median waiting time was 9.5 mo.Twenty-nine received transarterial chemoembolization (TACE) as a bringing and 16 no treatment before transplantation.Five HIFU therapy.Another five the same tumor staging (within UCSF...
In solid tumors, hypoxia triggers an aberrant vasculogenesis, enhances malignant character, and elevates metastatic risk. The plasma membrane organizing protein caveolin-1 (Cav1) is increased in a variety of cancers, including hepatocellular carcinoma (HCC), where it contributes to capability. However, the reason for elevation Cav1 tumor cells mechanistic basis its contributions risk are not fully understood. Here, we show that HCC cells, expression Cav1, which then acts through...