A5008794738- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- IgG4-Related and Inflammatory Diseases
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
- Genetic and Kidney Cyst Diseases
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal and related cancers
- Renal cell carcinoma treatment
- Congenital Anomalies and Fetal Surgery
- Peptidase Inhibition and Analysis
- Drug Transport and Resistance Mechanisms
- Macrophage Migration Inhibitory Factor
- Endoplasmic Reticulum Stress and Disease
- Hedgehog Signaling Pathway Studies
- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
Kanazawa University
2016-2025
Takara (Japan)
2004-2024
Kanazawa Medical University
2023-2024
Kobe University
2012-2022
Obayashi (Japan)
2022
Institute of Electrical and Electronics Engineers
2021
Centro Regional de Derechos Humanos y Justicia de Género, Corporación Humanas
2014-2020
Osaka University
2020
Kanazawa University Hospital
2011-2019
Institute for Public Relations
2019
Immunoglobin G (IgG) 4-related sclerosing pancreatitis and cholangitis (autoimmune pancreato-cholangitis [AIPC]) are recently recognized disease entities characterized by high serum IgG4 concentrations inflammation with numerous IgG4-positive plasma cells, although the underlining immune mechanism remains only speculative. In this study, immunopathogenesis of AIPC was examined respect to production cytokines in situ possible involvement regulatory T cells (Tregs) using fresh (5 cases)...
Sclerosing cholangitis (SC) is a heterogeneous disease entity. Different etiologies such as choledocholithiasis, biliary tumor, or pericholangitis can manifest SC. Hepatic inflammatory pseudotumor (IP) rarely associated with SC (sclerosing hepatic pseudotumor; SC-hepatic IP), but sclerosing pancreatitis (SP) not infrequently bile duct lesions pancreatitis-associated cholangitis; SP-SC). In this study, we compared the histologic changes of hilar and extrahepatic (7 cases), IP (5 SP-SC typical...
Chronic sclerosing sialadenitis (CSS) is a cryptogenic tumor-like condition of the salivary gland(s). While immune-mediated processes are suspected in its pathogenesis, and CSS occasionally reported to be associated with pancreatitis, an IgG4-related disease, exact immunopathologic remain speculative. In this study, we examined clinicopathologic findings (12 cases) comparison sialolithiasis (8 Sjögren's syndrome (13 cases), tried clarify whether disease or not. Submandibular gland(s) were...
Combined hepatocellular/cholangiocarcinomas have been explained by some investigators as bidirectional differentiation of neoplastic progenitor cell populations. The presence hepatic cells has now confirmed in humans, though whether they can give rise to malignant tumours not confirmed. We report four cases small identified livers with features chronic hepatitis which may suggest a role for transformation stem malignancies.Tumour samples were studied from patients histochemistry and...
Recently the authors proposed a new staging and grading system for primary biliary cirrhosis (PBC) that takes into account necroinflammatory activity histological heterogeneity. Herein is convenient version of this system. Scores fibrosis, bile duct loss, chronic cholestasis were combined staging: stage 1, total score 0; 2, 1–3; 3, 4–6; 4, 7–9. Cholangitis (CA) hepatitis (HA) graded as CA0–3, HA0–3, respectively. Analysis interobserver agreement was then conducted. Digital images 62 needle...
Summary An innate immune response to bacterial components is speculated be involved in the pathogenesis of primary biliary cirrhosis (PBC). Recently, CD4-positive T helper type 17 (Th17) cells, characterized by secretion interleukin (IL)-17, have been implicated autoimmune diseases. Human Th17 cells are generated from Th0 IL-6 and IL-1β maintained IL-23. In this study, role IL-17 PBC its association with immunity were examined. Using cultured human epithelial (BECs), expression Th17-related...
Abstract High‐grade pancreatic intraepithelial neoplasia (HG‐PanIN) is the major precursor of ductal adenocarcinoma (PDAC) and an ideal target for early detection. To characterize pure HG‐PanIN, we analysed 23 isolated HG‐PanIN lesions occurring in absence PDAC. Whole‐exome sequencing five these revealed a median 33 somatic mutations per lesion, with total 318 mutated genes. Targeted next‐generation 17 identified KRAS 94% lesions. CDKN2A alterations occurred six lesions, RNF43 five....
Primary biliary cirrhosis (PBC) is characterized by chronic nonsuppurative destructive cholangitis (CNSDC) associated with destruction of small bile ducts. Although there have been significant advances in the dissection adaptive immune response against mitochondrial autoantigens, are increasing data that suggest a contribution innate mechanisms inducing pathology. We taken advantage our ability to isolate subpopulations liver mononuclear cells (LMC) and examined herein role Toll-like...
Immunoglobulin G4 (IgG4)–related aortitis/periaortitis and periarteritis are vascular manifestations of IgG4-related disease. In this disease, the affected aneurysmal lesion has been suspected to be at risk rupture. study, we aimed clarify clinical course after corticosteroid therapy in periarteritis. We retrospectively evaluated features, including laboratory data, imaging findings therapy, 40 patients diagnosed with on basis periaortic/periarterial radiological findings, satisfaction...
BackgroundThere is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this study was assess the safety, tolerability, and effect PRI-724, a small-molecule modulator Wnt signaling, in patients with HCV cirrhosis.MethodsIn single-center, open-label, phase 1 trial, we sequentially enrolled cirrhosis who were classified as Child-Pugh (CP) class A or B. PRI-724 administered continuous intravenous infusion 10, 40, 160 mg/m2/day for six cycles...
OBJECTIVE Nonalcoholic fatty liver disease (NAFLD) is a phenotype of type 2 diabetes and obesity. Currently, the efficacy sodium–glucose cotransporter (SGLT2) inhibitors sulfonylureas in pathology hepatic gene expression profiles for with NAFLD are unknown. RESEARCH DESIGN AND METHODS We conducted 48 week, randomized, open-label, parallel-group trial involving participants biopsy-confirmed NAFLD. A total 40 were randomly assigned to receive once daily 20 mg tofogliflozin or 0.5 glimepiride....
This paper presents the first version of clinical practice guidelines for intrahepatic cholangiocarcinoma (ICC) established by Liver Cancer Study Group Japan. These consist 1 treatment algorithm, 5 background statements, 16 questions, and topic, including etiology, staging, pathology, diagnosis, treatments. Globally, a high incidence ICC has been reported in East Southeast Asian countries, gradually increasing Japan also Western countries. Reported risk factors include cirrhosis, hepatitis...
Abstract Hepatocellular death increases with hepatic steatosis aggravation, although its regulation remains unclear. Here we show that aggravation shifts the hepatocellular mode from apoptosis to necroptosis, causing increased death. Our results reveal transcription factor ATF3 acts as a master regulator in this shift by inducing expression of RIPK3, necroptosis. In severe steatosis, after partial hepatectomy, ATF3-deficient or -overexpressing mice display decreased RIPK3 and respectively....
Abstract Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal mixed features of both, causing diagnostic uncertainty and difficulty in determining proper management. Here, we perform a comprehensive deep learning-based phenotyping multiple cohorts patients. We show that learning can reproduce the diagnosis HCC...
The incidence and significance of hepatocellular carcinoma (HCC) in non‐alcoholic steatohepatitis (NASH) has not been previously evaluated detail. We recently experienced a case NASH with multicentric HCC female patient. At the age 58 years, patient was diagnosed non‐insulin‐dependent diabetes mellitus, treated by insulin therapy. did drink alcohol. She negative for all serological markers hepatitis B C virus infection. Because liver dysfunction, needle biopsy performed at 62 pathological...
Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by destruction of the intrahepatic bile ducts. It generally believed that cellular immune mechanisms, particularly involving T cells, result in this duct damage. The relative strength Th1 and Th2 responses has recently been proposed to be important factor pathophysiology various diseases. In study, we have attempted identify Th subset balance PBC, detection cytokines specific two T-cell subsets, i.e., interferon γ...
Primary biliary cirrhosis (PBC) is characterized by an immune-mediated destruction of intrahepatic small bile ducts. Apoptosis, a unique pattern cell death, has been suggested to be responsible for the in PBC. To address this issue, we attempted detect apoptosis epithelial cells situ nick-end labeling and expression apoptosis-related proteins using immunohistochemistry patients with various hepatobiliary diseases, including The data was noteworthy several reasons. First, occasionally...
Fractalkine is a chemokine with both chemoattractant and cell-adhesive functions, in the intestine it involved its receptor CX3CR1 chemoattraction recruitment of intraepithelial lymphocytes. We examined pathophysiological roles fractalkine normal diseased bile ducts. Expression were liver tissues from patients primary biliary cirrhosis (17 cases) controls (9 cases sclerosing cholangitis, 10 extrahepatic obstruction, 20 chronic viral hepatitis C, 18 histologically livers). epithelial cells...
To clarify the innate immunity of intrahepatic biliary tree, we examined expression Toll-like receptors and intracellular signalings in epithelial cells response to bacterial components by using cultured (murine human cholangiocarcinoma cell lines). The was reverse transcription PCR immunohistochemistry. Intracellular after activation lipopolysaccharide analysis nuclear factor (NF)-kappaB inhibition studies inhibitors for NF-kappaB mitogen-activated protein kinase blocking antibody. mRNAs 2,...
Chronic cholestasis often results in premature death from liver failure with fibrosis; however, the molecular mechanisms contributing to biliary cirrhosis are not demonstrated. In this article, we show that signal mediated by TNF-related apoptosis-inducing ligand (TRAIL) receptor 2/death 5 (DR5) may be a key regulator of cholestatic injury. Agonistic anti-DR5 monoclonal antibody treatment triggered cholangiocyte apoptosis, and subsequently induced cholangitis injury mouse strain-specific...
Intrahepatic cholangiocarcinoma (ICC) is highly fatal because of early invasion, widespread metastasis, and lack an effective therapy. We examined roles CXCR4 its ligand, stromal cell-derived factor (SDF)-1, in migration ICC with respect to tumor-stromal interaction by using two cell lines, a fibroblast line (WI-38), 28 human tissues. The lines expressed mRNA protein, WI-38 fibroblasts SDF-1 protein. Migration cultured cells Matrigel was induced co-culture incubation SDF-1. Anti-SDF-1...